Detalhe da pesquisa
1.
SPOP loss of function protects against tauopathy.
Proc Natl Acad Sci U S A
; 120(1): e2207250120, 2023 01 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36574656
2.
Transcriptomic evaluation of tau and TDP-43 synergism shows tauopathy predominance and reveals potential modulating targets.
Neurobiol Dis
; 193: 106441, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38378122
3.
Tau-RNA complexes inhibit microtubule polymerization and drive disease-relevant conformation change.
Brain
; 146(8): 3206-3220, 2023 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36732296
4.
Genome wide analysis reveals heparan sulfate epimerase modulates TDP-43 proteinopathy.
PLoS Genet
; 15(12): e1008526, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31834878
5.
Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects.
Proc Natl Acad Sci U S A
; 116(10): 4696-4705, 2019 03 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30770445
6.
The tau tubulin kinases TTBK1/2 promote accumulation of pathological TDP-43.
PLoS Genet
; 10(12): e1004803, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25473830
7.
Loss of RAD-23 Protects Against Models of Motor Neuron Disease by Enhancing Mutant Protein Clearance.
J Neurosci
; 35(42): 14286-306, 2015 Oct 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-26490867
8.
The phosphatase calcineurin regulates pathological TDP-43 phosphorylation.
Acta Neuropathol
; 132(4): 545-61, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27473149
9.
CDC7 inhibition blocks pathological TDP-43 phosphorylation and neurodegeneration.
Ann Neurol
; 74(1): 39-52, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23424178
10.
Transgenic Dendra2::tau expression allows in vivo monitoring of tau proteostasis in Caenorhabditis elegans.
Dis Model Mech
; 17(3)2024 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38469687
11.
sut-2 loss of function mutants protect against tau-driven shortened lifespan and hyperactive pharyngeal pumping in a C. elegans model of tau toxicity.
MicroPubl Biol
; 20232023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37602280
12.
Simple models to understand complex disease: 10 years of progress from Caenorhabditis elegans models of amyotrophic lateral sclerosis and frontotemporal lobar degeneration.
Front Neurosci
; 17: 1300705, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-38239833
13.
Cytochrome P450 and Epoxide Hydrolase Metabolites in Aß and tau-induced Neurodegeneration: Insights from Caenorhabditis elegans.
bioRxiv
; 2023 Oct 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37873467
14.
Loss of aly/ALYREF suppresses toxicity in both tau and TDP-43 models of neurodegeneration.
Geroscience
; 44(2): 747-761, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35122183
15.
TDP-43 promotes tau accumulation and selective neurotoxicity in bigenic Caenorhabditis elegans.
Dis Model Mech
; 15(4)2022 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35178571
16.
Phosphorylation promotes neurotoxicity in a Caenorhabditis elegans model of TDP-43 proteinopathy.
J Neurosci
; 30(48): 16208-19, 2010 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21123567
17.
Tau and TDP-43 synergy: a novel therapeutic target for sporadic late-onset Alzheimer's disease.
Geroscience
; 43(4): 1627-1634, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34185246
18.
Evaluation of Motor Impairment in C. elegans Models of Amyotrophic Lateral Sclerosis.
J Vis Exp
; (175)2021 09 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34542535
19.
Regulation of TDP-43 phosphorylation in aging and disease.
Geroscience
; 43(4): 1605-1614, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34032984
20.
Targeting nuclear protein TDP-43 by cell division cycle kinase 7 inhibitors: A new therapeutic approach for amyotrophic lateral sclerosis.
Eur J Med Chem
; 210: 112968, 2021 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33139113