[Increased sensitivity of cancer patients to ganglionic blockaders during anesthesia]. / O povyshennoi chuvstvitel'nosti onkologicheskikh bol'nykh k ganglioblokatoram vo vremia obezbolivaniia.

The experience with application of gangliolytic drugs in the surgical treatment of 1,380 cancer patients is discussed. It was found that cancer patients' increased sensitivity to the said drugs is due to disorders in neuro-humoral regulation of adaptation and vascular tension as well as occult hypovolemia. These disturbances are intensified with tumor advancement. Recommendations to improve preoperative premedication are given. The dosage of gangliolytic drugs used for anesthesia in cancer patients should be 20-30% lower than that in general surgical cases.

[Changes in the cytostatic and cytotoxic activities of the peripheral blood lymphocytes in the surgical treatment of lung cancer patients]. / Izmenenie tsitostaticheskoi i tsitotoksicheskoi aktivnosti limfotsitov perifericheskoi krovi pri khirurgicheskom lechenii bol'nykh rakom legkogo.

Cytostatic and cytotoxic activity of peripheral blood lymphocytes was studied in 30 cases of lung cancer. Enhanced cytostatic activity of lymphocytes was initially recorded. The level of natural antitumor resistance was maintained by means of neurovegetative inhibition used to prevent surgical stress.

[Changes in hormonal-mediatory and immunological indices during anesthesia in cancer patients]. / Izmeneniia gormonal'no-mediatornykh i immunologicheskikh pokazatelei vo vremia obezbolivaniia u onkologicheskikh bol'nykh.

The relationship between hormone-mediator and immunologic components of homeostasis was studied in 82 surgically-treated cancer patients. The pattern of changes in immunity and non-specific resistance was found to depend on the rate of glucocorticoid hormones synthesis in adrenals. Surgery should be carried out under neurovegetative blockade, which prevents immunodepression both during and shortly after surgery.