Establishment of a value evaluation system for health and wellness tourism resources: Reflections on China's official tourism resource evaluation criteria.

In recent years, China's sub-healthy and aging populations have increased dramatically, giving rise to a series of health and wellness needs. People prefer health and wellness tourism activities instead of sightseeing tourism activities because of the increasing emphasis on safety and experience. Health and wellness tourism resources are a prerequisite for the development of health and wellness tourism. To critically reflect on China's official tourism resource evaluation criteria, expert consultation was carried out by applying the Delphi method, and index weights were determined using the analytic hierarchy process. Through three rounds of expert consultation, a value evaluation system for health and wellness tourism resources was established and improved in three aspects: construction of an index system, selection of evaluation subjects, and grade discourse description, thus enhancing the feasibility and application value of the evaluation system. The system developed in this study not only enables a reflection on China's official tourism resource evaluation criteria, but also presents a new approach in the value evaluation research of health and wellness tourism resources.

Near-infrared upconversion multimodal nanoparticles for targeted radionuclide therapy of breast cancer lymphatic metastases.

The theranostics of lymph node metastasis has always been one of the major obstacles to defeating breast cancer and an important decisive factor in the prognosis of patients. Herein, we design NaGdF4:Yb,Tm@NaLuF4 upconversion nanoparticles with PEG and anti-HER2 monoclonal antibody (trastuzumab, Herceptin) (NP-mAb), the delivery of NP-mAb through the lymphatic system allows for effective targeting and accumulation in lymphatic metastasis. Combination of radionuclides 68Ga and 177Lu could be chelated by the bisphosphate groups of NP-mAb. The obtained nanoprobe (NP-mAb) and nanonuclear drug (68Ga-NP-mAb or 177Lu-NP-mAb) exhibited excellent stability and show high accumulation and prolong retention in the lymph node metastasis after intratumoral injection into the foot pad by near-infrared fluorescence (NIRF), single-photon emission computed tomography (SPECT) and positron emission tomography (PET) imaging. Utilizing the ß-rays released by 177Lu, 177Lu-NP-mAb could not only decrease the incidence of lymph node metastasis, but also significantly decrease the volumes of lymph node metastasis. Additionally, 177Lu-NP-mAb induce no obvious toxicity to treated mice through blood routine, liver and kidney function assay. Therefore, nanoprobe and nanonuclear drug we designed could be acted as excellent theranostics agents for lymph node metastasis, providing potential alternatives diagnose and treatment option for lymph node metastasis.