Detalhe da pesquisa
1.
Complement factor B is critical for sub-RPE deposit accumulation in a model of Doyne honeycomb retinal dystrophy with features of age-related macular degeneration.
Hum Mol Genet
; 32(2): 204-217, 2023 01 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35943778
2.
Small-molecule factor B inhibitor for the treatment of complement-mediated diseases.
Proc Natl Acad Sci U S A
; 116(16): 7926-7931, 2019 04 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-30926668
3.
Small-molecule factor D inhibitors targeting the alternative complement pathway.
Nat Chem Biol
; 12(12): 1105-1110, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27775713
4.
Specific correlation between the major chromosome 10q26 haplotype conferring risk for age-related macular degeneration and the expression of HTRA1.
Mol Vis
; 23: 318-333, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28659708
5.
A proteogenomic signature of age-related macular degeneration in blood.
Nat Commun
; 13(1): 3401, 2022 06 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-35697682
6.
Differential and Altered Spatial Distribution of Complement Expression in Age-Related Macular Degeneration.
Invest Ophthalmol Vis Sci
; 62(7): 26, 2021 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34160562
7.
Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases.
J Med Chem
; 63(11): 5697-5722, 2020 06 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32073845
8.
Design, Synthesis, and Preclinical Characterization of Selective Factor D Inhibitors Targeting the Alternative Complement Pathway.
J Med Chem
; 62(9): 4656-4668, 2019 05 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30995036
9.
Amount of Mononuclear Phagocyte Infiltrate Does Not Predict Area of Experimental Choroidal Neovascularization (CNV).
J Ocul Pharmacol Ther
; 34(7): 489-499, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30188257
10.
Induction of Ocular Complement Activation by Inflammatory Stimuli and Intraocular Inhibition of Complement Factor D in Animal Models.
Invest Ophthalmol Vis Sci
; 59(2): 940-951, 2018 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29450541
11.
Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo.
J Med Chem
; 60(13): 5717-5735, 2017 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28621538
12.
Lack of involvement of CEP adducts in TLR activation and in angiogenesis.
PLoS One
; 9(10): e111472, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25343517
13.
Ikkepsilon regulates viral-induced interferon regulatory factor-3 activation via a redox-sensitive pathway.
Virology
; 353(1): 155-65, 2006 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16806387
14.
Validation of the anti-inflammatory properties of small-molecule IkappaB Kinase (IKK)-2 inhibitors by comparison with adenoviral-mediated delivery of dominant-negative IKK1 and IKK2 in human airways smooth muscle.
Mol Pharmacol
; 70(2): 697-705, 2006 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16687566
15.
Tumor necrosis factor-alpha triggers mucus production in airway epithelium through an IkappaB kinase beta-dependent mechanism.
J Biol Chem
; 280(43): 36510-7, 2005 Oct 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-16123045
16.
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.
Nat Immunol
; 4(5): 491-6, 2003 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-12692549