RESUMO
Microwave-assisted organic synthesis (MAOS) is rapidly becoming recognized as a valuable tool for easing some of the bottlenecks in the drug discovery process. This article outlines the basic principles behind the technology and summarizes the areas in which microwave technology has made an impact, to date.
Assuntos
Química Orgânica/instrumentação , Micro-Ondas , Farmacologia/instrumentação , Preparações Farmacêuticas/síntese química , Preparações Farmacêuticas/química , Preparações Farmacêuticas/isolamento & purificação , EsterilizaçãoRESUMO
Microwave assisted organic synthesis (MAOS) is rapidly gaining acceptance as a valuable tool for relieving some of the bottlenecks in the drug discovery process. This article outlines the basic principles behind the technology and summarizes recent trends and areas in drug discovery where microwave technology has made an impact.
Assuntos
Técnicas de Química Combinatória/métodos , Desenho de Fármacos , Micro-Ondas , Preparações Farmacêuticas/síntese químicaRESUMO
It was in the 1980 s that the first papers in which the use of either combinatorial methods or microwave heating in organic chemistry were published. Unlike combinatorial chemistry, which quite readily became an accepted method, particularly in the pharmaceutical industry, it is only now that microwave heating is truly gaining acceptance. Our aim in this review is to attempt to rationalize this slow acceptance and to show the benefits to be gained by employing microwave heating in tandem with combinatorial chemistry. We will also give a number of examples of successful applications.