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1.
BMC Surg ; 23(1): 351, 2023 Nov 17.
Artigo em Inglês | MEDLINE | ID: mdl-37978496

RESUMO

BACKGROUND: Orbital wall fractures can result in changes to the bony orbital volume and soft tissue. Restoring the bony orbital and intraconal fat volumes is crucial to prevent posttraumatic enophthalmos and hypoglobus. We aimed to establish an evidence-based medical reference point for "mirroring" in orbital wall reconstruction, which incorporates three-dimensional (3D)-printing and navigation-assisted surgery, by comparing bilateral bony orbital volumes. METHODS: We retrospectively analyzed the data obtained from 100 Korean adults who did not have orbital wall fractures, categorized by age groups. The AVIEW Research software (Coreline Soft Inc., Seoul, South Korea) was used to generate 3D reformations of the bony orbital cavity, and bony orbital volumes were automatically calculated after selecting the region of interest on consecutive computed tomography slices. RESULTS: The mean left and right orbital volume of males in their 20 s was 24.67 ± 2.58 mL and 24.70 ± 2.59 mL, respectively, with no significant difference in size (p = 0.98) and Pearson's correlation coefficient of 0.977 (p < 0.001). No significant differences were found in orbital volumes in other age groups without fractures or in patients with nasal bone fractures (p = 0.84, Pearson's correlation coefficient 0.970, p < 0.001). The interclass correlation coefficients (2,1) for inter- and intrarater reliability were 0.97 (p < 0.001) and 0.99 (p < 0.001), respectively. CONCLUSIONS: No significant differences were found in the bilateral bony orbital volumes among males of any age. Thus, the uninjured orbit can be used as a volumetric reference point for the contralateral injured orbit during orbital wall reconstruction.


Assuntos
Imageamento Tridimensional , Fraturas Orbitárias , Masculino , Humanos , Adulto , Estudos Retrospectivos , Reprodutibilidade dos Testes , Fraturas Orbitárias/diagnóstico por imagem , Fraturas Orbitárias/cirurgia , Impressão Tridimensional , República da Coreia
2.
Aesthet Surg J ; 43(12): NP1052-NP1060, 2023 Nov 16.
Artigo em Inglês | MEDLINE | ID: mdl-37437176

RESUMO

BACKGROUND: The first step in successful breast reconstruction is obtaining a stable skin flap. Indocyanine green (ICG) angiography has recently been studied for its value and usefulness in predicting the stability of skin flaps; however, relevant prospective studies of its clinical efficacy are limited. OBJECTIVES: The aim of this study was to prospectively investigate the clinical impact on breast reconstruction outcomes of the intraoperative use of ICG angiography. METHODS: Between March and December 2021, 64 patients who underwent immediate breast reconstruction at the authors' institution were prospectively enrolled. They were classified into an experimental group (n = 39; undergoing ICG angiography) and a control group (n = 25; undergoing gross inspection alone). In the absence of viable skin, debridement was performed at the surgeon's discretion. Skin complications were categorized as skin necrosis (the transition of the skin flap to full-thickness necrosis) or skin erosion (a skin flap that did not deteriorate or become necrotic but lacked intactness). RESULTS: The 2 groups were matched in terms of basic demographic characteristics and incision line necrosis ratio (P = .354). However, intraoperative debridement was significantly more frequent in the experimental group (51.3% vs 48.0%, P = .006). The authors additionally classified skin flap necrosis into partial- and full-thickness necrosis, with a higher predominance of partial-thickness necrosis in the experimental vs control group (82.8% vs 55.6%; P = .043). CONCLUSIONS: Intraoperative ICG angiography does not directly minimize skin erosion or necrosis. However, compared to gross examination alone, it enables surgeons to perform a more active debridement during surgery, thereby contributing to a lower incidence of advanced skin necrosis. In breast reconstruction, ICG angiography may be useful for assessing the viability of the postmastectomy skin flap and could contribute to successful reconstruction. LEVEL OF EVIDENCE: 4.


Assuntos
Neoplasias da Mama , Mamoplastia , Humanos , Feminino , Mastectomia , Verde de Indocianina , Estudos Prospectivos , Corantes , Angiografia , Mamoplastia/efeitos adversos , Complicações Pós-Operatórias/epidemiologia , Necrose/etiologia
3.
BMC Surg ; 22(1): 358, 2022 Oct 11.
Artigo em Inglês | MEDLINE | ID: mdl-36221130

RESUMO

BACKGROUND: Autologous split-thickness skin grafts (STSGs) remain the mainstay for treatment of large skin defects. Despite its many advantages, there exist critical disadvantages such as unfavorable scar and graft contracture. In addition, it cannot be used when structures such as tendons and bones are exposed. To overcome these limitations, acellular dermal matrix (ADM) is widely used with STSG. CGDerm Matrix®, which was recently developed, is a novel reprocessed micronized ADM (RMADM). In this study, outcomes of the combined application of RMADM and STSG on full-thickness wounds were analyzed. METHODS: Forty-one patients with full-thickness skin defects due to trauma, scar contracture release, and diabetic foot ulcers, who underwent STSGs, from January 2021 to July 2021, were retrospectively reviewed. The primary outcome of interest was skin loss rate, which was measured 14 days after surgery. RESULTS: The most common cause of skin defect was trauma (36 patients), diabetic foot (2 patients), scar contracture release (2 patients), and malignancy (1 patient). The average defect size was 109.6 cm2 (range, 8-450 cm2). The average skin loss rate was 9.1%, showing a graft take rate of > 90%. CONCLUSION: The use of combined RMADM and STSG in full-thickness wound reconstruction provides stable and acceptable outcomes. The newly developed ADM can be a promising option in wound reconstruction.


Assuntos
Derme Acelular , Contratura , Pé Diabético , Cicatriz/etiologia , Pé Diabético/cirurgia , Humanos , Estudos Retrospectivos , Transplante de Pele , Cicatrização
4.
BMC Emerg Med ; 22(1): 123, 2022 07 07.
Artigo em Inglês | MEDLINE | ID: mdl-35799105

RESUMO

PURPOSE: A multidisciplinary approach is essential for trauma patients' treatment, particularly for cases with open lower extremity fractures, which are considered major traumas requiring a comprehensive approach. Recently, the social demand for severe-trauma centers has increased. This study analyzed the clinical impact of establishing a trauma center for the treatment of open lower extremity fractures. METHODS: A retrospective chart review was conducted for trauma patients admitted to our hospital. Patients were classified into two groups: before (January 2014-December 2015, 178 patients) and after establishment of a Level-1 trauma center (January 2017-December 2018, 125 patients). We included patients with open fracture below the knee level and Gustilo type II/III, but excluded those with life-threatening trauma that affected the treatment choice. RESULTS: Total 273 patient were included in this study, initial infection was significantly more common and external fixator application significantly less in post-center establishment group. The time to emergency operation decreased significantly from 13.89 ± 17.48 to 11.65 ± 19.33 h post-center setup. By multivariate analysis, the decreased primary amputation and increased limb salvage was attributed to establishment of the trauma center. CONCLUSION: With the establishment of the Level-1 trauma center, limbs of patients with open lower extremity fractures could be salvaged, and the need for primary amputation was decreased. Early control of initial open wound infection and minimizing external fixator use allowed early soft tissue reconstruction. The existence of the center ensured a shorter interval to emergency operation and facilitated interdepartmental cooperation, which promoted active limb salvage and contributed to patients' quality of life.


Assuntos
Fraturas Expostas , Centros de Traumatologia , Fraturas Expostas/cirurgia , Humanos , Extremidade Inferior/lesões , Extremidade Inferior/cirurgia , Qualidade de Vida , Estudos Retrospectivos , Resultado do Tratamento
5.
Adv Skin Wound Care ; 35(4): 234-237, 2022 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-35311768

RESUMO

ABSTRACT: Necrotizing fasciitis is a type of soft tissue infection that destroys subcutaneous tissue. It is particularly dangerous for patients with chronic diseases and those who are bedridden while recuperating. Although necrotizing fasciitis is often caused by trauma or postoperative infection, in rare cases, it can be attributed to pressure injury (PI). The disease progression is very aggressive and can be lethal for patients who are bedridden or immunocompromised.This case report describes a 47-year-old man with a history of diabetes and hypertension who became bedridden after a sudden status decline caused by nephrotic syndrome. He gradually developed an infection and rare deterioration of a PI on his upper back. After radiologic evaluation with magnetic resonance imaging and computed tomography, surgical intervention was performed and necrotizing fasciitis was confirmed. In this case of necrotizing fasciitis derived from a PI on the upper back, the infected area spread to the periphery at a rapid rate. The infection spread over his back and across the T1-T9 levels.In this report, the authors describe the integrated system of the thoracolumbar fascia and the very aggressive spread of necrotizing fasciitis. Because of the anatomic structure of the back and the characteristics of this infection, only aggressive surgical debridement could prevent the spread of infection and reduce the systemic effects of the infection. Physicians should be aware of the possibility of PIs in bedridden patients and, in cases of exacerbation of the wound, consider rapid surgical intervention after prompt examination and diagnosis to reduce mortality.


Assuntos
Fasciite Necrosante , Úlcera por Pressão , Humanos , Masculino , Pessoa de Meia-Idade , Fasciite Necrosante/diagnóstico , Fasciite Necrosante/etiologia , Fasciite Necrosante/terapia , Imageamento por Ressonância Magnética
6.
J Craniofac Surg ; 30(2): 478-482, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30640856

RESUMO

BACKGROUND: Open reduction followed by internal fixation has been regarded as the most effective technique for the surgical repair of zygomatic fractures. However, the ideal number and locations of internal fixation points to maintain stable reduction remain controversial. Using 3-dimensional computed tomography, we aimed to compare the stability of 2-point and 3-point fixation among patients who had undergone surgical repair of zygomatic bone fractures. METHODS: The study included 22 patients (17 men, 5 women) with unilateral zygomatic bone fractures who had undergone open reduction with 2-point or three-point fixation using biodegradable materials (11 patients in each group). The authors measured the lateral projection and height of the zygoma at 2 landmark points (zygomaticofacial foramen and frontozygomatic suture). In each group, bony displacement was analyzed between the preoperative and immediate postoperative phases, and between the preoperative and follow-up phases. Differences in stability between the 2 groups were analyzed by comparing values between the immediate postoperative and follow-up phases. RESULTS: The 2-point group exhibited a lower rate of complex fractures at the frontozygomatic suture than the 3-point group (18.2%, 63.6%, respectively). In both groups, the authors observed significant differences in the lateral projection of the zygomaticofacial foramen between the preoperative and immediate postoperative phases, and between the preoperative and follow-up phases. No significant differences in stability were observed between the groups. CONCLUSION: Our findings demonstrated that 2-point fixation of the zygoma with biodegradable materials is as stable as 3-point fixation. It could be initially considered when open reduction of frontozygomatic suture was not essential.


Assuntos
Imageamento Tridimensional/métodos , Redução Aberta , Tomografia Computadorizada por Raios X/métodos , Zigoma , Fraturas Zigomáticas , Implantes Absorvíveis , Adulto , Placas Ósseas , Feminino , Fixação Interna de Fraturas/instrumentação , Fixação Interna de Fraturas/métodos , Humanos , Masculino , Pessoa de Meia-Idade , Redução Aberta/métodos , Avaliação de Resultados em Cuidados de Saúde/métodos , República da Coreia , Zigoma/diagnóstico por imagem , Zigoma/lesões , Zigoma/cirurgia , Fraturas Zigomáticas/diagnóstico , Fraturas Zigomáticas/cirurgia
7.
J Korean Med Sci ; 33(20): e150, 2018 May 14.
Artigo em Inglês | MEDLINE | ID: mdl-29760607

RESUMO

BACKGROUND: Previous research has related obesity to body dissatisfaction and low self-esteem. This study aimed to evaluate this relation between obesity and distress about appearance. METHODS: We performed a cross-sectional study using data from the Korea Youth Risk Behavior Web-based Survey for 288,390 participants assessed from 2009 to 2012. The participants were categorized according to body mass index; obese, overweight, healthy weight, and underweight. The relation between obesity and distress was analyzed using simple and multiple logistic regression with complex sampling adjusted for age, sex, region of residence, economic level, parental education level, alcohol consumption, and smoking habits as confounders. RESULTS: The adjusted odds ratio (AOR) was higher for participants with obesity (AOR for healthy weight = 1.15 [95% confidence interval {CI}, 1.08-1.22]; AOR for overweight = 1.85 [95% CI, 1.72-1.98]; AOR for obese = 2.45 [95% CI, 2.27-2.64]; reference = underweight, P < 0.001). In males, healthy weight was associated with an AOR below 1 (AOR for healthy weight = 0.92 [95% CI, 0.85-0.99]; AOR for overweight = 1.26 [95% CI, 1.14-1.38]; AOR for obese = 1.66 [95% CI, 1.50-1.84], P < 0.001). In females, higher AORs were associated with obesity (AOR for healthy weight = 1.44 [95% CI, 1.33-1.57]; AOR for overweight = 2.71 [95% CI, 2.45-2.99]; AOR for obese = 3.71 [95% CI, 3.32-4.14], P < 0.001). CONCLUSION: Obesity is related to distress about appearance, and the relation is stronger in girls than in boys.


Assuntos
Obesidade/diagnóstico , Estresse Psicológico , Adolescente , Povo Asiático , Índice de Massa Corporal , Peso Corporal , Criança , Estudos Transversais , Feminino , Humanos , Internet , Modelos Logísticos , Masculino , Obesidade/epidemiologia , Razão de Chances , Sobrepeso/diagnóstico , Sobrepeso/epidemiologia , República da Coreia/epidemiologia , Inquéritos e Questionários
8.
J Craniofac Surg ; 28(7): 1649-1653, 2017 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-28891893

RESUMO

Nasal bone fracture is the most common facial fracture; however, surgery does not guarantee reduction and complications, such as undercorrection, overcorrection, and deviation, may occur. By analyzing findings of computed tomography (CT) immediately and at 3 months postoperatively, we evaluated the accuracy of reduction and long-term changes to the nasal bone.Patients with pure nasal bone fracture were evaluated from January 1, 2010 to December 31, 2011. First, we categorized fracture types according to the Stranc-Robertson classification system, using preoperative CT findings (ie, F1, F2, L1, and L2). We categorized each result of reduction by immediate postoperative CT scan findings as "Excellent," "Good," "Fair," and "Poor," with "Excellent" and "Good" ratings being considered a "Success." We evaluated changes to the nasal bone at 3 months after reduction, using the same grade.A total of 128 patients were analyzed. The results of patients in the F1 group were better than those of other patients immediately postoperatively, whereas those of the L2 group were worse. The overall success rate was 49.2% (58/118). At 3 months postoperatively, 33 cases exhibited an improvement to a higher grade, whereas 25 cases improved from an unacceptable outcome to a successful outcome, with the overall success rate being 70.3% (83/118).Immediately postoperative CT scans can be helpful for surgeons in determining whether a secondary adjustment is necessary. Incompletely reduced nasal bone showed spontaneous improvement in bony arrangement according to our study, so simple observation could be a choice.


Assuntos
Fixação de Fratura/métodos , Osso Nasal/cirurgia , Fraturas Cranianas/cirurgia , Humanos , Complicações Pós-Operatórias , Tomografia Computadorizada por Raios X
9.
J Craniofac Surg ; 28(8): 2038-2041, 2017 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-28938317

RESUMO

The treatment has been improved on the accurate reduction of blow-out fracture for many decades. But still, it has been limited to reduce completely when surgeons are approaching by conventional technique. The authors analyzed the postoperative results using computed tomography (CT) scans after conventional open reduction of isolated medial wall fracture. Thirty-seven patients with isolated medial wall fracture were reviewed. All patients underwent preoperative, immediate, and postoperative CT scans. Two surgeons have performed the surgery by conventional open reduction with transcaruncular approach and absorbable mesh insertion. The authors evaluated changing orbital volume and distance, comparing the immediate and 6 months postoperative outcomes with preoperative outcome. The differences between immediate postoperative and 6 months postoperatively data were statistically evaluated. The authors used the distant value to minimize bias of CT view selection. Significant differences from the 2 kinds of data were observed (P < 0.05 for volume, P < 0.01 for distance, Paired t test). Bone remodeling process after conventional open reduction of orbital wall has not been fully understood. Most popular technique is conventional open reduction and mesh insertion but it is not easy for surgeons to reduce fractured bones completely. The authors analyzed the bone remodeling after incomplete reduction. These results suggest that the decreased measurements might be caused from the scar contracture with fibrosis. This research is very limited to explain the change while bone remodeling is progressed. Further research should be continued to discover the understanding of the process.


Assuntos
Órbita/diagnóstico por imagem , Órbita/cirurgia , Fraturas Orbitárias/cirurgia , Adolescente , Adulto , Idoso , Remodelação Óssea , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Redução Aberta , Período Pós-Operatório , Fatores de Tempo , Tomografia Computadorizada por Raios X , Resultado do Tratamento , Adulto Jovem
10.
Ann Plast Surg ; 76(1): 23-8, 2016 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-25325390

RESUMO

Many surgical procedures to improve mandibular contour have been introduced in East Asia. Despite consensus regarding mandible contouring surgery, surgery which includes angle ostectomy and lateral cortex excision, some patients require only mandibular angle ostectomy. The intraoral approach is a widely used method, but has disadvantages with regard to the need for endotracheal intubation and patients are limited in their food intake for a considerable length of time. The authors wanted to shorten the recovery period and so the postauricular approach is introduced in this study and assessed.One hundred seventy-five Asian patients underwent mandibular angle ostectomy via a postauricular approach. All operations were performed under intravenous sedation without endotracheal intubation. Superficial subcutaneous dissection and vertical dissection were performed, with special care taken to avoid injuring the facial nerve. Patients responded to a simple questionnaire during the postoperative period. Questions solicited the patient's reason for their choice of this approach and their satisfaction with it.No visible scar and no palpable bony step were observed without ear pulling. Some patients experienced temporary sensory changes in the postauricular area. None of the patients complained of perioral numbness or facial paralysis. Six patients had significant bleeding in the operative field and 1 patient experienced salivary leakage for 2 weeks which was managed well without event. Of the 175 patients, 133 responded to the questionnaire. Satisfaction was expressed by 94.7% of patients and 88.7% of patients would recommend this surgery to their friends; 69.2% of patients experienced inconvenience for 1 week or less.The postauricular approach for mandibular angle ostectomy is a very convenient method for surgeons to use for patients who want to undergo mandibular angle ostectomy with a short recovery time.


Assuntos
Pavilhão Auricular/cirurgia , Mandíbula/cirurgia , Osteotomia/métodos , Satisfação do Paciente/estatística & dados numéricos , Recuperação de Função Fisiológica/fisiologia , Adulto , Estudos de Coortes , Estética , Feminino , Humanos , Masculino , Mandíbula/diagnóstico por imagem , Pessoa de Meia-Idade , Duração da Cirurgia , Cuidados Pós-Operatórios/métodos , Procedimentos de Cirurgia Plástica/métodos , República da Coreia , Estudos Retrospectivos , Fatores de Tempo , Tomografia Computadorizada por Raios X/métodos
11.
J Craniofac Surg ; 27(2): e215-7, 2016 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-26967101

RESUMO

Patients with forehead mass have a cosmetic problem because the forehead is an important first impression. Conventional skin approach results in visible scar even though surgeons designed the incision along the relaxed skin tension line1. Since Onishi introduced the technique for endoscopic approach in 1995, endoscopic surgery has become rapidly popular in the field of plastic surgery. Endoscopic approach to the forehead mass by small incision on the scalp behind hair line is big advantageous for leaving less ugly scar on the forehead. All procedures need to be identified under the endoscopic visualization. When it was completed, the mass was pulled out. The authors also used the osteotome or rasp when it was the osteoma. The forehead and scalp were applied compressive dressing to prevent hematoma and swelling for 2 days. The cosmesis was excellent because they have no visible scar on the forehead. Endoscopic approaching technique is getting popular and commonly used during the cosmetic surgery because it has many advantages. This method also, however, has difficulties to remove large-sized mass and to perform caudal dissection, and for increased operative times. Furthermore, there are complication of incomplete removal, hematoma, and swelling. The proper candidate is the patient with smooth forehead, with a mobile and soft mass, with a propensity for keloid formation, or hypertrophic scarring. Endoscopic technique is not only advantageous but also disadvantageous. That is why surgeon's selection is more important.


Assuntos
Endoscopia/métodos , Testa/cirurgia , Osteoma/cirurgia , Couro Cabeludo/cirurgia , Neoplasias Cranianas/cirurgia , Cicatriz/etiologia , Cicatriz/prevenção & controle , Endoscopia/instrumentação , Estética , Humanos , Cuidados Pós-Operatórios/métodos , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/prevenção & controle , Instrumentos Cirúrgicos
12.
J Craniofac Surg ; 27(6): e513-4, 2016 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-27607126

RESUMO

Fractures of the zygoma are relatively frequent and their management has been extensively described. Above all, isolated zygomatic arch fractures comprise about 10% of all zygomatic fractures. Temporal approach is common surgical method, Gillies approach, but it has the limitation of blinded surgical approach. So, the mobile intraoperative fluoroscan is used famously for more suitable reduction, but it needs an additional man to control the machine and increases irradiation doses. The authors got the simple idea, but so helpful tool, and it has been performed since 2012. The authors have gotten good surgical results, so introduce this idea that favors the surgery on isolated zygomatic arch fracture.


Assuntos
Meios de Contraste/farmacologia , Fixação Interna de Fraturas/métodos , Cuidados Pré-Operatórios/métodos , Radiografia/métodos , Zigoma/diagnóstico por imagem , Fraturas Zigomáticas/diagnóstico , Fios Ortopédicos , Humanos , Masculino , Doses de Radiação , Zigoma/lesões , Fraturas Zigomáticas/cirurgia
13.
J Craniofac Surg ; 27(1): 64-9, 2016 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-26745190

RESUMO

BACKGROUND: A number of studies have shown that facial asymmetry improves in congenital muscular torticollis (CMT) patients after surgical release. This study confirmed the improvement in facial asymmetry, and analyzed factors that affect the change of facial asymmetry in CMT patients after surgical release by using objective and quantitative methods. METHODS: Facial asymmetry was analyzed in 60 CMT patients who underwent surgical release before 10 years of age. Horizontal and lower facial asymmetry angles (HFAA and LFAA) in the clinical photograph were used to measure facial asymmetry. Postoperative improvements in HFAA and LFAA were evaluated in each age group, after grouping the patients by age. Patients were divided into 2 groups according to the postoperative head tilt and functional deficit. Postoperative improvements in HFAA and LFAA were compared between 2 groups. The relationships between postoperative improvements in HFAA and LFAA and independent variables (age, follow-up period, preoperative HFAA or LFAA, postoperative head tilt, and postoperative functional deficit) were analyzed. RESULTS: Mean age at operation was 34.8 months (range, 6-120 mo). Horizontal facial asymmetry angle was improved significantly postoperatively in groups <5 years of age. Lower facial asymmetry angle was improved significantly postoperatively in all age groups. No significant difference was found in the postoperative improvements in HFAA and LFAA between 2 groups according to the postoperative head tilt and functional deficit. In the correlation analysis, postoperative improvements in HFAA and LFAA were proportional to the follow-up period (r = 0.256, P = 0.048) and preoperative HFAA or LFAA (r = 0.600, P < 0.001). CONCLUSIONS: Facial asymmetry in CMT patients can be improved in part if surgical release is performed before 10 years of age and the possibility of improvement may be different according to the area of the face. After surgical release, facial asymmetry will improve over a long period of time, and patients with more severe facial asymmetry have a better remodeling potential to achieve facial symmetry.


Assuntos
Assimetria Facial/terapia , Torcicolo/congênito , Criança , Pré-Escolar , Feminino , Seguimentos , Humanos , Lactente , Masculino , Músculos do Pescoço/fisiopatologia , Músculos do Pescoço/cirurgia , Maleabilidade , Amplitude de Movimento Articular/fisiologia , Rotação , Torcicolo/cirurgia , Resultado do Tratamento
14.
Mol Carcinog ; 54(12): 1605-12, 2015 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-25328065

RESUMO

Non-melanoma skin cancers (NMSC) including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are more common kinds of skin cancer. Although these tumors share common pathological and clinical features, their similarity and heterogeneity at molecular levels are not fully elaborated yet. Here, by performing comparative analysis of gene expression profiling of BCC, SCC, and normal skin tissues, we could classify the BCC into three subtypes of classical, SCC-like, and normal-like BCCs. Functional enrichment and pathway analyses revealed the molecular characteristics of each subtype. The classical BCC showed the enriched expression and transcription signature with the activation of Wnt and Hedgehog signaling pathways, which were well known key features of BCC. By contrast, the SCC-like BCC was enriched with immune-response genes and oxidative stress-related genes. Network analysis revealed the PLAU/PLAUR as a key regulator of SCC-like BCC. The normal-like BCC showed prominent activation of metabolic processes particularly the fatty acid metabolism. The existence of these molecular subtypes could be validated in an independent dataset, which demonstrated the three subgroups of BCC with distinct functional enrichment. In conclusion, we suggest a novel molecular classification of BCC providing insights on the heterogeneous progression of BCC.


Assuntos
Carcinoma Basocelular/genética , Neoplasias Cutâneas/genética , Transcriptoma/genética , Idoso , Idoso de 80 Anos ou mais , Feminino , Perfilação da Expressão Gênica/métodos , Proteínas Hedgehog/genética , Humanos , Masculino , Pessoa de Meia-Idade , Estresse Oxidativo/genética , Transdução de Sinais/genética , Pele/metabolismo
15.
J Oral Maxillofac Surg ; 72(3): 604.e1-14, 2014 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-24528566

RESUMO

PURPOSE: To evaluate outcomes of total subcondylar excision of mandibular condylar osteochondroma. PATIENTS AND METHODS: Two adult patients presented with progressive facial asymmetry, jaw deviation, and limited mouth opening. Computed tomogram (CT) showed a large osseous tumor arising from the right condyle occupying the subtemporal space in these patients. Complete surgical excision was performed without condyle reconstruction. The pathology report indicated osteochondroma. Patients were followed for an average of 5 years. RESULTS: Long-term evaluation showed restoration of dento-occlusal function and facial appearance. Follow-up CT showed a partly regenerated and remodeled condyle. Patients' chewing function was acceptable, but predominantly on the lesion side. CONCLUSIONS: Condylar osteochondroma caused jaw deviation and joint dysfunction. Complete surgical excision achieved an adequate long-term outcome, but condylar reconstruction is advisable.


Assuntos
Assimetria Facial/etiologia , Hematoma/cirurgia , Côndilo Mandibular/cirurgia , Neoplasias Mandibulares/cirurgia , Osteocondroma/cirurgia , Neoplasias Cranianas/cirurgia , Adulto , Anquilose/etiologia , Anquilose/cirurgia , Oclusão Dentária , Assimetria Facial/cirurgia , Feminino , Seguimentos , Hematoma/complicações , Humanos , Masculino , Má Oclusão/etiologia , Má Oclusão/cirurgia , Côndilo Mandibular/diagnóstico por imagem , Neoplasias Mandibulares/complicações , Neoplasias Mandibulares/diagnóstico por imagem , Mastigação , Pessoa de Meia-Idade , Osteocondroma/complicações , Osteocondroma/diagnóstico por imagem , Avaliação de Resultados em Cuidados de Saúde , Estudos Retrospectivos , Neoplasias Cranianas/diagnóstico por imagem , Neoplasias Cranianas/patologia , Tomografia Computadorizada por Raios X
16.
J Craniofac Surg ; 25(4): 1376-8, 2014 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-24902109

RESUMO

Skull base reconstruction presents a challenging therapeutic problem requiring a multispecialty surgical approach and close cooperation between the neurosurgeon, head and neck surgeon, as well as plastic and reconstructive surgeon during all stages of treatment. The principal goal of skull base reconstruction is to separate the intracranial space from the nasopharyngeal and oropharyngeal cavities, creating support for the brain and providing a water-tight barrier against cerebrospinal fluid leakage and ascending infection. We present a case involving a 58-year-old man with anterior skull base defects (2.5 cm × 3 cm) secondary to the removal of olfactory neuroblastoma. The patient received conventional radiation therapy at 6000 cGy in 30 fractions approximately a month before tumor removal. The patient had radiation therapy before surgery and was planned to have postoperative radiation therapy, which would lead to a higher complication rate of reconstruction. Artificial dura was used for the packing of the dural defect, which was also suspected to increase the complication rate of reconstruction. For these reasons, we chose to apply the dual flap technique, which uses both local pericranial flap and de-epithelized radial forearm free flap for anterior skull base defect to promote wound healing. During 28 months of follow-up after coverage of the anterior skull base defect, the dual flap survived completely, as confirmed through follow-up magnetic resonance imaging. The patient was free of cerebrospinal fluid leakage, meningitis, and abscess, and there was minimal donor-site morbidity of the radial forearm free flap. Reconstruction of anterior skull base defects using the dual flap technique is safe, reliable, and associated with low morbidity, and it is ideal for irradiated wounds and low-volume defects.


Assuntos
Estesioneuroblastoma Olfatório/cirurgia , Retalhos de Tecido Biológico/transplante , Cavidade Nasal/cirurgia , Neoplasias Nasais/cirurgia , Procedimentos de Cirurgia Plástica/métodos , Base do Crânio/cirurgia , Retalhos Cirúrgicos/transplante , Abscesso/prevenção & controle , Vazamento de Líquido Cefalorraquidiano/prevenção & controle , Estesioneuroblastoma Olfatório/radioterapia , Seguimentos , Antebraço/cirurgia , Sobrevivência de Enxerto , Humanos , Imageamento por Ressonância Magnética/métodos , Masculino , Meningite/prevenção & controle , Pessoa de Meia-Idade , Cavidade Nasal/efeitos da radiação , Neoplasias Nasais/radioterapia , Neoplasias dos Seios Paranasais/cirurgia , Radioterapia Adjuvante , Rádio (Anatomia)/cirurgia , Base do Crânio/efeitos da radiação , Neoplasias da Base do Crânio/cirurgia , Infecção da Ferida Cirúrgica/prevenção & controle , Sítio Doador de Transplante/cirurgia
17.
J Craniofac Surg ; 24(2): 458-60, 2013 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-23524714

RESUMO

Wide excision of cancer arising from the tonsillar fossa and soft palate has several functional sequelae (e.g., speech, swallowing, chewing, and breathing) that require surgical restoration of the pharyngeo-palatal structure and optimal velopharyngeal function. For this purpose, several kinds of surgical procedures have been introduced. Our method to reconstruct the tonsillar fossa and soft palate entails folding the flaps and reconstructions at the same time as the oral and nasal planes, with some modifications.Patient 1 was a 64-year-old man with left soft palate cancer. After wide excision of the tumor, the defect size of the nasal floor was 3 × 3 cm, and that of soft palate and tonsillar fossa was 8 × 5 cm. Patient 2 was a 49-year-old man with left tonsil cancer. The defect size of the nasal floor was 3 × 3 cm, and that of left lateral wall of the tonsillar fossa was 8 × 3 cm. For reconstruction of oral, nasal, and tonsillar plane, we designed the flap fit to the defect site, especially cutting of the edge of the square plane of the flap to a round shape.Both patients achieved good functional recovery without surgical complications. The average speech intelligibility score in the 2 patients was 10. Swallowing functional score was 4 in both patients. Creative reconstruction with modified radial forearm free flap for tonsillar and soft palate area makes it possible to restore velopharyngeal function to levels close to the preoperative condition.


Assuntos
Carcinoma de Células Escamosas/cirurgia , Neoplasias Orofaríngeas/cirurgia , Palato/cirurgia , Retalhos Cirúrgicos/irrigação sanguínea , Antebraço/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Esvaziamento Cervical , Neoplasias Tonsilares/cirurgia
18.
J Plast Reconstr Aesthet Surg ; 82: 92-102, 2023 07.
Artigo em Inglês | MEDLINE | ID: mdl-37156109

RESUMO

BACKGROUND: Giselleligne is the world's first multiphasic gel product that evenly surrounds particles. In the current study, Giselleligne was compared with other existing fillers to evaluate their clinical use, safety, and ability to improve midface volume deficits of Asian individuals. METHODS: A comparative experiment was conducted to gain an understanding of the physical properties of Giselleligne, which is a multilayered hyaluronic acid filler, and to compare its properties with those of existing hyaluronic acid fillers. The primary outcome of this study was a Midface Volume Deficit Scale (MFVDS) score improvement at 24 weeks after the procedure. The secondary outcomes were as follows: MFVDS score improvement after the procedure; MFVDS score changes after the procedure; Global Esthetic Improvement Scale (GAIS) scores as evaluated by the operator after the procedure; the operator's satisfaction with the product; evaluation of the GAIS scores by the patient after the procedure; and pain level of the patient on the day of the procedure. RESULTS: Giselleligne exhibited properties that are expected to result in significantly superior clinical outcomes compared to existing products. Giselleligne was superior not only to the existing products but also in terms of global esthetic improvement, effect duration, and operator satisfaction. Furthermore, Giselleligne was found significantly safer than the existing products. CONCLUSION: Giselleligne is a safer, more user-friendly, and more effective alternative to existing products for improving the midfacial volume.


Assuntos
Técnicas Cosméticas , Preenchedores Dérmicos , Envelhecimento da Pele , Humanos , Ácido Hialurônico , Face , Método Duplo-Cego , Resultado do Tratamento
19.
J Craniofac Surg ; 23(3): 856-8, 2012 May.
Artigo em Inglês | MEDLINE | ID: mdl-22565908

RESUMO

Le Fort III distraction osteogenesis (DO) is a useful procedure for treating midface hypoplasia. The external distraction system has the advantage of allowing modification of the distraction vector during the activation period. This system needs an intraoral splint for the anchorage points. The intraoral splint has an important role in conducting the distraction force to the midface and in forming the advancement vector. The authors developed a modified type of splint to improve the outcome of Le Fort III DO.The intraoral splint is composed of a modified headgear face bow, molar bands, and a palatal acrylic plate without covering the teeth. Four suspension wires were applied to reinforce the stability. The zygomatic bones and the loops of the splint are selected as 4 anchorage points for Le Fort III DO. This procedure was applied to 2 patients.The midface had an advancement of more than 20 mm in both patients. The dental movement of the upper incisors and the upper first molar was minimal.The dental effect was nearly absent. The amount and vector of distraction could be decided under direct observation without blocking the dental occlusion. The vector of distraction could be adjusted during the activation period. The results of DO were satisfactory.


Assuntos
Disostose Craniofacial/cirurgia , Placas Oclusais , Osteogênese por Distração/métodos , Osteotomia de Le Fort/métodos , Cefalometria , Criança , Feminino , Humanos , Masculino , Osteogênese por Distração/instrumentação , Osteotomia de Le Fort/instrumentação
20.
J Craniofac Surg ; 23(3): e251-3, 2012 May.
Artigo em Inglês | MEDLINE | ID: mdl-22627448

RESUMO

Classic approach of the anterior wall of frontal sinus fracture involves bicoronal or direct forehead incisions. However, these methods have some disadvantages, for example, paresthesia, scarring, and even alopecia. The purpose of this study was to introduce the simple and effective method of reduction of the anterior wall of frontal sinus fracture with threaded K-wires. Thirteen patients with fracture of the anterior wall of the frontal sinus underwent our method from December 2005 to September 2011. The distance of threaded K-wires was measured by facial computed tomography, and those marks were made directly on the threaded K-wires with an aseptic pencil. Closed reduction with these K-wires was tried carefully until a tolerable level was attained with digital palpation. Facial computed tomography was performed the following day for comparison. On postoperative day 7, following disappearance of swelling, the patient and the doctor mutually evaluated the outcome; both were satisfied with the results. The postoperative course was uneventful, without any complications. Unlike other methods, this method can guarantee a short operating time, effective reduction, and inconspicuous scar.


Assuntos
Fios Ortopédicos , Fixação Interna de Fraturas/instrumentação , Seio Frontal/lesões , Seio Frontal/cirurgia , Fraturas Cranianas/cirurgia , Feminino , Seio Frontal/diagnóstico por imagem , Humanos , Masculino , Fraturas Cranianas/diagnóstico por imagem , Tomografia Computadorizada por Raios X
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