Detalhe da pesquisa
1.
Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606.
J Pharmacol Exp Ther
; 362(1): 31-44, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28416568
2.
Preclinical validation of a potent γ-secretase modulator for Alzheimer's disease prevention.
J Exp Med
; 218(4)2021 04 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33651103
3.
CSF as a surrogate for assessing CNS exposure: an industrial perspective.
Curr Drug Metab
; 9(1): 46-59, 2008 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18220571
4.
Applications and limitations of genetically modified mouse models in drug discovery and development.
Curr Drug Metab
; 9(5): 419-38, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18537578
5.
Pharmacokinetic and pharmacodynamic variability: a daunting challenge in drug therapy.
Curr Drug Metab
; 8(2): 109-36, 2007 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17305491
6.
Transporter-mediated drug interactions: clinical implications and in vitro assessment.
Expert Opin Drug Metab Toxicol
; 3(1): 81-92, 2007 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17269896
7.
Tissue distribution and pharmacodynamics: a complicated relationship.
Curr Drug Metab
; 7(1): 39-65, 2006 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-16454692
8.
A prostate-specific antigen (PSA)-activated vinblastine prodrug selectively kills PSA-secreting cells in vivo.
Mol Cancer Ther
; 1(7): 451-9, 2002 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-12479263
9.
Drug-drug interaction mediated by inhibition and induction of P-glycoprotein.
Adv Drug Deliv Rev
; 55(1): 53-81, 2003 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-12535574
10.
Complexities of glucuronidation affecting in vitro in vivo extrapolation.
Curr Drug Metab
; 3(6): 623-46, 2002 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-12369890
11.
Evaluation of drug interactions with P-glycoprotein in drug discovery: in vitro assessment of the potential for drug-drug interactions with P-glycoprotein.
Curr Drug Metab
; 3(3): 257-73, 2002 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-12083320
12.
Design and synthesis of a pro-drug of vinblastine targeted at treatment of prostate cancer with enhanced efficacy and reduced systemic toxicity.
J Med Chem
; 45(21): 4706-15, 2002 Oct 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-12361397
13.
Role of P-glycoprotein in pharmacokinetics: clinical implications.
Clin Pharmacokinet
; 42(1): 59-98, 2003.
Artigo
em Inglês
| MEDLINE | ID: mdl-12489979
14.
Using real-time quantitative TaqMan RT-PCR to evaluate the role of dexamethasone in gene regulation of rat P-glycoproteins mdr1a/1b and cytochrome P450 3A1/2.
J Pharm Sci
; 93(10): 2488-96, 2004 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-15349958
15.
An in-vitro cocktail assay for assessing compound-mediated inhibition of six major cytochrome P450 enzymes.
J Pharm Anal
; 4(4): 270-278, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-29403890
16.
Pharmacokinetics of biotech drugs: peptides, proteins and monoclonal antibodies.
Curr Drug Metab
; 10(7): 661-91, 2009 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-19702530
17.
CYP induction-mediated drug interactions: in vitro assessment and clinical implications.
Pharm Res
; 23(6): 1089-116, 2006 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-16718615
18.
Complicating factors in safety testing of drug metabolites: kinetic differences between generated and preformed metabolites.
Toxicol Appl Pharmacol
; 217(2): 143-52, 2006 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17055014
19.
In vitro and in vivo CYP3A64 induction and inhibition studies in rhesus monkeys: a preclinical approach for CYP3A-mediated drug interaction studies.
Drug Metab Dispos
; 34(9): 1546-55, 2006 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-16782766
20.
Metabolism-based drug-drug interactions: what determines individual variability in cytochrome P450 induction?
Drug Metab Dispos
; 33(5): 603-13, 2005 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15673596