Detalhe da pesquisa
1.
Differential inhibition of sildenafil and macitentan on saxagliptin metabolism.
Toxicol Appl Pharmacol
; 486: 116934, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38663673
2.
Evaluation of Recombinant CYP3A4 Variants on the Metabolism of Oxycodone In Vitro.
Chem Res Toxicol
; 34(1): 103-109, 2021 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33393779
3.
Characterization of Genetic Variation in CYP3A4 on the Metabolism of Cabozantinib in Vitro.
Chem Res Toxicol
; 32(8): 1583-1590, 2019 08 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-31293154
4.
An imbalanced GLP-1R/GIPR co-agonist peptide with a site-specific N-terminal PEGylation to maximize metabolic benefits.
iScience
; 27(4): 109377, 2024 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38510128
5.
Structural basis and selectivity of sulfatinib binding to FGFR and CSF-1R.
Commun Chem
; 7(1): 3, 2024 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38172256
6.
Design, synthesis, and biological evaluation of selective covalent inhibitors of FGFR4.
Eur J Med Chem
; 268: 116281, 2024 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38432058
7.
Discovery of 6-Formylpyridyl Urea Derivatives as Potent Reversible-Covalent Fibroblast Growth Factor Receptor 4 Inhibitors with Improved Anti-Hepatocellular Carcinoma Activity.
J Med Chem
; 67(4): 2667-2689, 2024 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38348819
8.
Genetic variations of CYP3A4 on the metabolism of itraconazole in vitro.
Food Chem Toxicol
; 181: 114101, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37863381
9.
Site-specific N-terminal PEGylation-based controlled release of biotherapeutics: An application for GLP-1 delivery to improve pharmacokinetics and prolong hypoglycemic effects.
Eur J Med Chem
; 242: 114672, 2022 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35973313
10.
Characterization of the cholangiocarcinoma drug pemigatinib against FGFR gatekeeper mutants.
Commun Chem
; 5(1): 100, 2022 Aug 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36698015
11.
Effects of 27 CYP3A4 protein variants on saxagliptin metabolism in vitro.
Fundam Clin Pharmacol
; 36(1): 150-159, 2022 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-33961299
12.
Design, Synthesis, and Biological Evaluation of Aminoindazole Derivatives as Highly Selective Covalent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR4.
J Med Chem
; 65(6): 5113-5133, 2022 03 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35271262
13.
Structure-based design of a dual-warhead covalent inhibitor of FGFR4.
Commun Chem
; 5(1): 36, 2022 Mar 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-36697897
14.
Discovery of D6808, a Highly Selective and Potent Macrocyclic c-Met Inhibitor for Gastric Cancer Harboring MET Gene Alteration Treatment.
J Med Chem
; 65(22): 15140-15164, 2022 11 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-36355693
15.
Investigation of the Inhibitory Effect of Simvastatin on the Metabolism of Lidocaine Both in vitro and in vivo.
Drug Des Devel Ther
; 14: 1739-1747, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32440099
16.
Drug-drug interaction study of imatinib and voriconazole in vitro and in vivo.
Infect Drug Resist
; 12: 1021-1027, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31118708
17.
Quantitative bioanalytical assay for the human epidermal growth factor receptor (HER) inhibitor dacomitinib in rat plasma by UPLC-MS/MS.
J Pharm Biomed Anal
; 166: 66-70, 2019 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-30612075
18.
Functional characteristics of CYP3A4 allelic variants on the metabolism of loperamide in vitro.
Infect Drug Resist
; 12: 2809-2817, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31571937
19.
Inhibitory Mechanisms of Myricetin on Human and Rat Liver Cytochrome P450 Enzymes.
Eur J Drug Metab Pharmacokinet
; 44(5): 611-618, 2019 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-30825074
20.
UPLC-MS/MS method for the simultaneous determination of imatinib, voriconazole and their metabolites concentrations in rat plasma.
J Pharm Biomed Anal
; 166: 6-12, 2019 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-30594035