Detalhe da pesquisa
1.
An in vivo duck hepatitis B virus model recapitulates key aspects of nucleic acid polymer treatment outcomes in chronic hepatitis B patients.
Antiviral Res
; 224: 105835, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38401714
2.
TMC647055, a potent nonnucleoside hepatitis C virus NS5B polymerase inhibitor with cross-genotypic coverage.
Antimicrob Agents Chemother
; 56(9): 4676-84, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22710121
3.
Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055.
Bioorg Med Chem Lett
; 22(13): 4437-43, 2012 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22633687
4.
Finger-loop inhibitors of the HCV NS5b polymerase. Part 1: Discovery and optimization of novel 1,6- and 2,6-macrocyclic indole series.
Bioorg Med Chem Lett
; 22(13): 4431-6, 2012 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22542193
5.
Discovery of 4'-azido-2'-deoxy-2'-C-methyl cytidine and prodrugs thereof: a potent inhibitor of Hepatitis C virus replication.
Bioorg Med Chem Lett
; 22(9): 3265-8, 2012 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22472694
6.
Antiviral activity and mode of action of TMC647078, a novel nucleoside inhibitor of the hepatitis C virus NS5B polymerase.
Antimicrob Agents Chemother
; 55(8): 3812-20, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21576430
7.
Tracking the evolution of multiple in vitro hepatitis C virus replicon variants under protease inhibitor selection pressure by 454 deep sequencing.
J Virol
; 84(21): 11124-33, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20739521
8.
JNJ-64794964 (AL-034/TQ-A3334), a TLR7 agonist, induces sustained anti-HBV activity in AAV/HBV mice via non-cytolytic mechanisms.
Antiviral Res
; 196: 105196, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34718044
9.
Mechanism and specificity of a symmetrical benzimidazolephenylcarboxamide helicase inhibitor.
Biochemistry
; 49(9): 1822-32, 2010 Mar 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-20108979
10.
In vitro resistance profile of the hepatitis C virus NS3/4A protease inhibitor TMC435.
Antimicrob Agents Chemother
; 54(5): 1878-87, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20176898
11.
Synthesis and SAR of potent inhibitors of the Hepatitis C virus NS3/4A protease: exploration of P2 quinazoline substituents.
Bioorg Med Chem Lett
; 20(14): 4004-11, 2010 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20541405
12.
Regulation of gene transcription by thyroid hormone receptor ß agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH).
PLoS One
; 15(12): e0240338, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33306682
13.
In vitro activity and preclinical profile of TMC435350, a potent hepatitis C virus protease inhibitor.
Antimicrob Agents Chemother
; 53(4): 1377-85, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19171797
14.
Antiviral suppression vs restoration of RIG-I signaling by hepatitis C protease and polymerase inhibitors.
Gastroenterology
; 135(5): 1710-1718.e2, 2008 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-18725224
15.
1,5-Benzodiazepine inhibitors of HCV NS5B polymerase.
Bioorg Med Chem Lett
; 19(9): 2492-6, 2009 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19342234
16.
Discovery of novel potent and selective dipeptide hepatitis C virus NS3/4A serine protease inhibitors.
Bioorg Med Chem Lett
; 18(18): 5095-100, 2008 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18722116
17.
Discovery of novel, potent and bioavailable proline-urea based macrocyclic HCV NS3/4A protease inhibitors.
Bioorg Med Chem Lett
; 18(23): 6189-93, 2008 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18954982
18.
Structure-activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350.
Bioorg Med Chem Lett
; 18(17): 4853-8, 2008 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18678486
19.
Structure-based macrocyclization yields hepatitis C virus NS5B inhibitors with improved binding affinities and pharmacokinetic properties.
Angew Chem Int Ed Engl
; 51(19): 4637-40, 2012 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-22473861
20.
Discovery of 1-((2R,4aR,6R,7R,7aR)-2-Isopropoxy-2-oxidodihydro-4H,6H-spiro[furo[3,2-d][1,3,2]dioxaphosphinine-7,2'-oxetan]-6-yl)pyrimidine-2,4(1H,3H)-dione (JNJ-54257099), a 3'-5'-Cyclic Phosphate Ester Prodrug of 2'-Deoxy-2'-Spirooxetane Uridine Triphosphate Useful for HCV Inhibition.
J Med Chem
; 59(12): 5790-8, 2016 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-27181575