Detalhe da pesquisa
1.
PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis.
Mol Cell
; 81(21): 4509-4526.e10, 2021 11 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34560002
2.
Virulence and Metabolism Crosstalk: Impaired Activity of the Type Three Secretion System (T3SS) in a Pseudomonas aeruginosa Crc-Defective Mutant.
Int J Mol Sci
; 24(15)2023 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37569678
3.
K63 polyubiquitination and activation of mTOR by the p62-TRAF6 complex in nutrient-activated cells.
Mol Cell
; 51(3): 283-96, 2013 Aug 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-23911927
4.
p62 is a key regulator of nutrient sensing in the mTORC1 pathway.
Mol Cell
; 44(1): 134-46, 2011 Oct 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-21981924
5.
Hyaluronan driven by epithelial aPKC deficiency remodels the microenvironment and creates a vulnerability in mesenchymal colorectal cancer.
Cancer Cell
; 41(2): 252-271.e9, 2023 02 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36525970
6.
Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis.
Nat Commun
; 14(1): 8075, 2023 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38092754
7.
Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis.
EMBO J
; 27(16): 2181-93, 2008 Aug 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-18650932
8.
Overproduction of the multidrug efflux pump MexEF-OprN does not impair Pseudomonas aeruginosa fitness in competition tests, but produces specific changes in bacterial regulatory networks.
Environ Microbiol
; 14(8): 1968-81, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22417660
9.
Protein kinase Cλ/ι in cancer: a contextual balance of time and signals.
Trends Cell Biol
; 32(12): 1023-1034, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35501226
10.
The lactate-NAD+ axis activates cancer-associated fibroblasts by downregulating p62.
Cell Rep
; 39(6): 110792, 2022 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35545049
11.
NBR1 is a critical step in the repression of thermogenesis of p62-deficient adipocytes through PPARγ.
Nat Commun
; 12(1): 2876, 2021 05 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34001883
12.
Stromal SOX2 Upregulation Promotes Tumorigenesis through the Generation of a SFRP1/2-Expressing Cancer-Associated Fibroblast Population.
Dev Cell
; 56(1): 95-110.e10, 2021 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33207226
13.
The global regulator Crc modulates metabolism, susceptibility to antibiotics and virulence in Pseudomonas aeruginosa.
Environ Microbiol
; 12(12): 3196-212, 2010 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-20626455
14.
PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression.
Cancer Cell
; 38(2): 247-262.e11, 2020 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32589943
15.
Mechanistic insight into the regulation of SQSTM1/p62.
Autophagy
; 15(4): 735-737, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30653391
16.
Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer.
Cancer Cell
; 35(3): 385-400.e9, 2019 03 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-30827887
17.
ZZ-dependent regulation of p62/SQSTM1 in autophagy.
Nat Commun
; 9(1): 4373, 2018 10 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-30349045
18.
ATF4-Induced Metabolic Reprograming Is a Synthetic Vulnerability of the p62-Deficient Tumor Stroma.
Cell Metab
; 26(6): 817-829.e6, 2017 Dec 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28988820
19.
p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells.
Cancer Cell
; 29(6): 935-948, 2016 06 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-27211490
20.
Amino Acid Activation of mTORC1 by a PB1-Domain-Driven Kinase Complex Cascade.
Cell Rep
; 12(8): 1339-52, 2015 Aug 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-26279575