Detalhe da pesquisa
1.
SERCA2 regulates proinsulin processing and processing enzyme maturation in pancreatic beta cells.
Diabetologia
; 66(11): 2042-2061, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37537395
2.
Design, synthesis, and characterization of novel fluorogenic substrates of the proprotein convertases furin, PC1/3, PC2, PC5/6, and PC7.
Anal Biochem
; 655: 114836, 2022 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35964735
3.
A comprehensive systematic review of CSF proteins and peptides that define Alzheimer's disease.
Clin Proteomics
; 17: 21, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32518535
4.
Cross-seeding of prions by aggregated α-synuclein leads to transmissible spongiform encephalopathy.
PLoS Pathog
; 13(8): e1006563, 2017 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-28797122
5.
The neural chaperone proSAAS blocks α-synuclein fibrillation and neurotoxicity.
Proc Natl Acad Sci U S A
; 113(32): E4708-15, 2016 08 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27457957
6.
Physiological signaling in the absence of amidated peptides.
Proc Natl Acad Sci U S A
; 116(40): 19774-19776, 2019 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31515450
7.
Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic ß cells.
Proc Natl Acad Sci U S A
; 111(22): E2319-28, 2014 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-24843127
8.
Chaperones in Neurodegeneration.
J Neurosci
; 35(41): 13853-9, 2015 Oct 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26468185
9.
The neuroendocrine protein 7B2 suppresses the aggregation of neurodegenerative disease-related proteins.
J Biol Chem
; 288(2): 1114-24, 2013 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-23172224
10.
A novel function for proSAAS as an amyloid anti-aggregant in Alzheimer's disease.
J Neurochem
; 128(3): 419-30, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24102330
11.
Congenital proprotein convertase 1/3 deficiency causes malabsorptive diarrhea and other endocrinopathies in a pediatric cohort.
Gastroenterology
; 145(1): 138-148, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23562752
12.
ProSAAS is Preferentially Secreted from Neurons During Homeostatic Scaling and Reduces Amyloid Plaque Size in the 5xFAD Mouse Hippocampus.
bioRxiv
; 2024 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38712265
13.
Highly potent inhibitors of proprotein convertase furin as potential drugs for treatment of infectious diseases.
J Biol Chem
; 287(26): 21992-2003, 2012 Jun 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-22539349
14.
Peptides derived from the prohormone proNPQ/spexin are potent central modulators of cardiovascular and renal function and nociception.
FASEB J
; 26(2): 947-54, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22038051
15.
Exome sequencing finds a novel PCSK1 mutation in a child with generalized malabsorptive diarrhea and diabetes insipidus.
J Pediatr Gastroenterol Nutr
; 57(6): 759-67, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24280991
16.
Generation and characterization of non-competitive furin-inhibiting nanobodies.
Biochem J
; 448(1): 73-82, 2012 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22920187
17.
The neuroendocrine protein 7B2 is intrinsically disordered.
Biochemistry
; 51(38): 7456-64, 2012 Sep 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-22947085
18.
Inhibition of prohormone convertases PC1/3 and PC2 by 2,5-dideoxystreptamine derivatives.
Mol Pharmacol
; 81(3): 440-54, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22169851
19.
Dynamic modulation of prohormone convertase 2 (PC2)-mediated precursor processing by 7B2 protein: preferential effect on glucagon synthesis.
J Biol Chem
; 286(49): 42504-42513, 2011 Dec 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-22013069
20.
Sequestration of TDP-43216-414 Aggregates by Cytoplasmic Expression of the proSAAS Chaperone.
ACS Chem Neurosci
; 13(11): 1651-1665, 2022 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35549000