Detalhe da pesquisa
1.
Targeted mutagenesis on PDGFRα-Fc identifies amino acid modifications that allow efficient inhibition of HCMV infection while abolishing PDGF sequestration.
PLoS Pathog
; 17(3): e1009471, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33780515
2.
Definitions of Resistant and Refractory Cytomegalovirus Infection and Disease in Transplant Recipients for Use in Clinical Trials.
Clin Infect Dis
; 68(8): 1420-1426, 2019 04 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30137245
3.
Mutual Interplay between the Human Cytomegalovirus Terminase Subunits pUL51, pUL56, and pUL89 Promotes Terminase Complex Formation.
J Virol
; 91(12)2017 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28356534
4.
Letermovir for cytomegalovirus prophylaxis in hematopoietic-cell transplantation.
N Engl J Med
; 370(19): 1781-9, 2014 May 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24806159
5.
Characterization of Cytomegalovirus Breakthrough Events in a Phase 2 Prophylaxis Trial of Letermovir (AIC246, MK 8228).
J Infect Dis
; 213(1): 23-30, 2016 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26113373
6.
In vitro drug combination studies of Letermovir (AIC246, MK-8228) with approved anti-human cytomegalovirus (HCMV) and anti-HIV compounds in inhibition of HCMV and HIV replication.
Antimicrob Agents Chemother
; 59(6): 3140-8, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25779572
7.
Geno- and phenotypic characterization of human cytomegalovirus mutants selected in vitro after letermovir (AIC246) exposure.
Antimicrob Agents Chemother
; 58(1): 610-3, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24189264
8.
Preemptive treatment of Cytomegalovirus infection in kidney transplant recipients with letermovir: results of a Phase 2a study.
Transpl Int
; 27(1): 77-86, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24164420
9.
In vitro evaluation of the activities of the novel anticytomegalovirus compound AIC246 (letermovir) against herpesviruses and other human pathogenic viruses.
Antimicrob Agents Chemother
; 56(2): 1135-7, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22106211
10.
The novel anticytomegalovirus compound AIC246 (Letermovir) inhibits human cytomegalovirus replication through a specific antiviral mechanism that involves the viral terminase.
J Virol
; 85(20): 10884-93, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21752907
11.
Nucleocytoplasmic shuttling and CRM1-dependent MHC class I peptide presentation of human cytomegalovirus pp65.
Med Microbiol Immunol
; 201(4): 567-79, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-22965172
12.
Exploring the Human Cytomegalovirus Core Nuclear Egress Complex as a Novel Antiviral Target: A New Type of Small Molecule Inhibitors.
Viruses
; 13(3)2021 03 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33809234
13.
Properties of Oligomeric Interaction of the Cytomegalovirus Core Nuclear Egress Complex (NEC) and Its Sensitivity to an NEC Inhibitory Small Molecule.
Viruses
; 13(3)2021 03 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33799898
14.
In vitro and in vivo activities of the novel anticytomegalovirus compound AIC246.
Antimicrob Agents Chemother
; 54(3): 1290-7, 2010 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-20047911
15.
Mismatch primer-based PCR reveals that helicase-primase inhibitor resistance mutations pre-exist in herpes simplex virus type 1 clinical isolates and are not induced during incubation with the inhibitor.
J Antimicrob Chemother
; 65(7): 1347-52, 2010 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20453068
16.
Inhibition of human cytomegalovirus replication via peptide aptamers directed against the nonconventional nuclear localization signal of the essential viral replication factor pUL84.
J Virol
; 83(22): 11902-13, 2009 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-19740994
17.
The UL69 transactivator protein of human cytomegalovirus interacts with DEXD/H-Box RNA helicase UAP56 to promote cytoplasmic accumulation of unspliced RNA.
Mol Cell Biol
; 26(5): 1631-43, 2006 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-16478985
18.
Antiviral strategies to combat cytomegalovirus infections in transplant recipients.
Curr Opin Pharmacol
; 8(5): 541-8, 2008 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-18662804
19.
RNA-binding of the human cytomegalovirus transactivator protein UL69, mediated by arginine-rich motifs, is not required for nuclear export of unspliced RNA.
Nucleic Acids Res
; 34(4): 1237-49, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-16500893
20.
Sox10 is an active nucleocytoplasmic shuttle protein, and shuttling is crucial for Sox10-mediated transactivation.
Mol Cell Biol
; 22(16): 5826-34, 2002 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-12138193