Pesquisa | Portal de Pesquisa da BVS

1.

Catch bonds in sickle cell disease: Shear-enhanced adhesion of red blood cells to laminin.

Goreke, Utku; Iram, Shamreen; Singh, Gundeep; Domínguez-Medina, Sergio; Man, Yuncheng; Bode, Allison; An, Ran; Little, Jane A; Wirth, Christopher L; Hinczewski, Michael; Gurkan, Umut A.

Biophys J ; 122(12): 2564-2576, 2023 06 20.

Artigo em Inglês | MEDLINE | ID: mdl-37177783

2.

Sickle red blood cell-derived extracellular vesicles activate endothelial cells and enhance sickle red cell adhesion mediated by von Willebrand factor.

An, Ran; Man, Yuncheng; Cheng, Kevin; Zhang, Tianyi; Chen, Chunsheng; Wang, Fang; Abdulla, Fuad; Kucukal, Erdem; Wulftange, William J; Goreke, Utku; Bode, Allison; Nayak, Lalitha V; Vercellotti, Gregory M; Belcher, John D; Little, Jane A; Gurkan, Umut A.

Br J Haematol ; 201(3): 552-563, 2023 05.

Artigo em Inglês | MEDLINE | ID: mdl-36604837

3.

Antithrombin-III mitigates thrombin-mediated endothelial cell contraction and sickle red blood cell adhesion in microscale flow.

Wulftange, William J; Kucukal, Erdem; Man, Yuncheng; An, Ran; Monchamp, Karamoja; Sevrain, Charlotte D; Dashora, Himanshu R; Owusu-Ansah, Amma T; Bode, Allison; Ilich, Anton; Little, Jane A; Key, Nigel S; Gurkan, Umut A.

Br J Haematol ; 198(5): 893-902, 2022 09.

Artigo em Inglês | MEDLINE | ID: mdl-35822297

4.

Standardized microfluidic assessment of red blood cell-mediated microcapillary occlusion: Association with clinical phenotype and hydroxyurea responsiveness in sickle cell disease.

Man, Yuncheng; Kucukal, Erdem; An, Ran; Bode, Allison; Little, Jane A; Gurkan, Umut A.

Microcirculation ; 28(2): e12662, 2021 02.

Artigo em Inglês | MEDLINE | ID: mdl-33025653

5.

Exercise-induced changes of vital signs in adults with sickle cell disease.

Johnson, Solomon; Gordeuk, Victor R; Machado, Roberto; Gibbs, J Simon R; Hildesheim, Mariana; Little, Jane A; Kato, Gregory J; Gladwin, Mark T; Nouraie, Mehdi.

Am J Hematol ; 96(12): 1630-1638, 2021 12 01.

Artigo em Inglês | MEDLINE | ID: mdl-34626431

6.

Venous Thromboembolism in Sickle Cell Disease is Associated with Neutrophilia.

Gollamudi, Jahnavi; Sarvepalli, Shashank; Vadaparti Binf, Animesh; Alin, Tara; Little, Jane A; Nayak, Lalitha.

Hemoglobin ; 45(1): 56-59, 2021 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-33588667

7.

Inhibition of Band 3 tyrosine phosphorylation: a new mechanism for treatment of sickle cell disease.

Noomuna, Panae; Risinger, Mary; Zhou, Sitong; Seu, Katie; Man, Yuncheng; An, Ran; Sheik, Daniel A; Wan, Jiandi; Little, Jane A; Gurkan, Umut A; Turrini, Francesco M; Kalfa, Theodosia; Low, Philip S.

Br J Haematol ; 190(4): 599-609, 2020 08.

Artigo em Inglês | MEDLINE | ID: mdl-32346864

8.

Leukocyte adhesion to P-selectin and the inhibitory role of Crizanlizumab in sickle cell disease: A standardized microfluidic assessment.

Man, Yuncheng; Goreke, Utku; Kucukal, Erdem; Hill, Ailis; An, Ran; Liu, Shichen; Bode, Allison; Solis-Fuentes, Ambar; Nayak, Lalitha V; Little, Jane A; Gurkan, Umut A.

Blood Cells Mol Dis ; 83: 102424, 2020 07.

Artigo em Inglês | MEDLINE | ID: mdl-32208292

9.

Whole blood viscosity and red blood cell adhesion: Potential biomarkers for targeted and curative therapies in sickle cell disease.

Kucukal, Erdem; Man, Yuncheng; Hill, Ailis; Liu, Shichen; Bode, Allison; An, Ran; Kadambi, Jaikrishnan; Little, Jane A; Gurkan, Umut A.

Am J Hematol ; 95(11): 1246-1256, 2020 11.

Artigo em Inglês | MEDLINE | ID: mdl-32656816

10.

Paper-based microchip electrophoresis for point-of-care hemoglobin testing.

Hasan, Muhammad Noman; Fraiwan, Arwa; An, Ran; Alapan, Yunus; Ung, Ryan; Akkus, Asya; Xu, Julia Z; Rezac, Amy J; Kocmich, Nicholas J; Creary, Melissa S; Oginni, Tolulope; Olanipekun, Grace Mfon; Hassan-Hanga, Fatimah; Jibir, Binta W; Gambo, Safiya; Verma, Anil K; Bharti, Praveen K; Riolueang, Suchada; Ngimhung, Takdanai; Suksangpleng, Thidarat; Thota, Priyaleela; Werner, Greg; Shanmugam, Rajasubramaniam; Das, Aparup; Viprakasit, Vip; Piccone, Connie M; Little, Jane A; Obaro, Stephen K; Gurkan, Umut A.

Analyst ; 145(7): 2525-2542, 2020 Apr 07.

Artigo em Inglês | MEDLINE | ID: mdl-32123889

11.

Priapism, hemoglobin desaturation, and red blood cell adhesion in men with sickle cell anemia.

Yuan, Charlotte; Quinn, Erina; Kucukal, Erdem; Kapoor, Sargam; Gurkan, Umut A; Little, Jane A.

Blood Cells Mol Dis ; 79: 102350, 2019 11.

Artigo em Inglês | MEDLINE | ID: mdl-31404907

12.

RBC, heal thyself: PK activators in SCD.

Little, Jane A.

Blood ; 140(19): 2005-2006, 2022 11 10.

Artigo em Inglês | MEDLINE | ID: mdl-36355466

13.

Association of silent infarcts in sickle cell anemia with decreased annexin A5 resistance.

Morrone, Kerry A; Pecker, Lydia H; Rand, Jacob; Davila, Jennifer; Oyeku, Suzette; Little, Jane A; Xiaonan, Xue; Manwani, Deepa.

Blood Cells Mol Dis ; 69: 53-56, 2018 03.

Artigo em Inglês | MEDLINE | ID: mdl-28911832

14.

Red Blood Cell Adhesion to Heme-Activated Endothelial Cells Reflects Clinical Phenotype in Sickle Cell Disease.

Kucukal, Erdem; Ilich, Anton; Key, Nigel S; Little, Jane A; Gurkan, Umut A.

Am J Hematol ; 2018 Jun 15.

Artigo em Inglês | MEDLINE | ID: mdl-29905377

15.

Hypoxia-enhanced adhesion of red blood cells in microscale flow.

Kim, Myeongseop; Alapan, Yunus; Adhikari, Anima; Little, Jane A; Gurkan, Umut A.

Microcirculation ; 24(5)2017 07.

Artigo em Inglês | MEDLINE | ID: mdl-28387057

16.

Gaps in the diagnosis and management of iron overload in sickle cell disease: a 'real-world' report from the GRNDaD registry.

Wilson, Samuel R; Sears, Matthew; Williams, Elizabeth; Drapekin, Jesse; Sivakumar, Ishwarya; Padrino, Susan; Desai, Payal C; Hager, Ward; Manwani, Deepa; Clay, Leila J; Field, Joshua J; Kanter, Julie; Cohen, Alice J; Saif Ur Rehman, Sana; Lanzkron, Sophie; Little, Jane A.

Br J Haematol ; 195(5): e157-e160, 2021 12.

Artigo em Inglês | MEDLINE | ID: mdl-34423416

17.

Intermediaries of branched chain amino acid metabolism induce fetal hemoglobin, and repress SOX6 and BCL11A, in definitive erythroid cells.

Karkashon, Shay; Raghupathy, Radha; Bhatia, Himanshu; Dutta, Amrita; Hess, Sonja; Higgs, Jaimie; Tifft, Cynthia J; Little, Jane A.

Blood Cells Mol Dis ; 55(2): 161-7, 2015 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-26142333

18.

Haemoglobinuria is associated with chronic kidney disease and its progression in patients with sickle cell anaemia.

Saraf, Santosh L; Zhang, Xu; Kanias, Tamir; Lash, James P; Molokie, Robert E; Oza, Bharvi; Lai, Catherine; Rowe, Julie H; Gowhari, Michel; Hassan, Johara; Desimone, Joseph; Machado, Roberto F; Gladwin, Mark T; Little, Jane A; Gordeuk, Victor R.

Br J Haematol ; 164(5): 729-39, 2014 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-24329963

19.

Intracardiac or intrapulmonary shunts were present in at least 35% of adults with homozygous sickle cell disease followed in an outpatient clinic.

Hambley, Bryan C; Rahman, Rania Abdul; Reback, Maxwell; O'Riordan, Mary Ann; Langer, Nathan; Gilkeson, Robert C; Ginwalla, Mahazarin; Little, Jane A; Schilz, Robert.

Haematologica ; 104(1): e1-e3, 2019 01.

Artigo em Inglês | MEDLINE | ID: mdl-30006446

20.

Validation of a composite vascular high-risk profile for adult patients with sickle cell disease.

Nouraie, Mehdi; Little, Jane A; Hildesheim, Mariana; Gibbs, J Simon R; Morris, Claudia R; Machado, Roberto F; Kato, Gregory J; Gordeuk, Victor R; Gladwin, Mark T.

Am J Hematol ; 94(12): E312-E314, 2019 12.

Artigo em Inglês | MEDLINE | ID: mdl-31444803

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