Pesquisa | Portal de Pesquisa da BVS

1.

TOP1 inhibition therapy protects against SARS-CoV-2-induced lethal inflammation.

Ho, Jessica Sook Yuin; Mok, Bobo Wing-Yee; Campisi, Laura; Jordan, Tristan; Yildiz, Soner; Parameswaran, Sreeja; Wayman, Joseph A; Gaudreault, Natasha N; Meekins, David A; Indran, Sabarish V; Morozov, Igor; Trujillo, Jessie D; Fstkchyan, Yesai S; Rathnasinghe, Raveen; Zhu, Zeyu; Zheng, Simin; Zhao, Nan; White, Kris; Ray-Jones, Helen; Malysheva, Valeriya; Thiecke, Michiel J; Lau, Siu-Ying; Liu, Honglian; Zhang, Anna Junxia; Lee, Andrew Chak-Yiu; Liu, Wen-Chun; Jangra, Sonia; Escalera, Alba; Aydillo, Teresa; Melo, Betsaida Salom; Guccione, Ernesto; Sebra, Robert; Shum, Elaine; Bakker, Jan; Kaufman, David A; Moreira, Andre L; Carossino, Mariano; Balasuriya, Udeni B R; Byun, Minji; Albrecht, Randy A; Schotsaert, Michael; Garcia-Sastre, Adolfo; Chanda, Sumit K; Miraldi, Emily R; Jeyasekharan, Anand D; TenOever, Benjamin R; Spivakov, Mikhail; Weirauch, Matthew T; Heinz, Sven; Chen, Honglin.

Cell ; 184(10): 2618-2632.e17, 2021 05 13.

Artigo em Inglês | MEDLINE | ID: mdl-33836156

2.

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.

Blanco-Melo, Daniel; Nilsson-Payant, Benjamin E; Liu, Wen-Chun; Uhl, Skyler; Hoagland, Daisy; Møller, Rasmus; Jordan, Tristan X; Oishi, Kohei; Panis, Maryline; Sachs, David; Wang, Taia T; Schwartz, Robert E; Lim, Jean K; Albrecht, Randy A; tenOever, Benjamin R.

Cell ; 181(5): 1036-1045.e9, 2020 05 28.

Artigo em Inglês | MEDLINE | ID: mdl-32416070

3.

Pervasive Chromatin-RNA Binding Protein Interactions Enable RNA-Based Regulation of Transcription.

Xiao, Rui; Chen, Jia-Yu; Liang, Zhengyu; Luo, Daji; Chen, Geng; Lu, Zhi John; Chen, Yang; Zhou, Bing; Li, Hairi; Du, Xian; Yang, Yang; San, Mingkui; Wei, Xintao; Liu, Wen; Lécuyer, Eric; Graveley, Brenton R; Yeo, Gene W; Burge, Christopher B; Zhang, Michael Q; Zhou, Yu; Fu, Xiang-Dong.

Cell ; 178(1): 107-121.e18, 2019 06 27.

Artigo em Inglês | MEDLINE | ID: mdl-31251911

4.

Brd4 and JMJD6-associated anti-pause enhancers in regulation of transcriptional pause release.

Liu, Wen; Ma, Qi; Wong, Kaki; Li, Wenbo; Ohgi, Kenny; Zhang, Jie; Aggarwal, Aneel; Rosenfeld, Michael G.

Cell ; 155(7): 1581-1595, 2013 Dec 19.

Artigo em Inglês | MEDLINE | ID: mdl-24360279

5.

CircPVT1 promotes ER-positive breast tumorigenesis and drug resistance by targeting ESR1 and MAVS.

Yi, Jia; Wang, Lei; Hu, Guo-Sheng; Zhang, Yue-Ying; Du, Jiao; Ding, Jian-Cheng; Ji, Xiang; Shen, Hai-Feng; Huang, Hai-Hua; Ye, Feng; Liu, Wen.

EMBO J ; 42(10): e112408, 2023 05 15.

Artigo em Inglês | MEDLINE | ID: mdl-37009655

6.

Heat-induced SUMOylation differentially affects bacterial effectors in plant cells.

Li, Wenliang; Liu, Wen; Xu, Zewei; Zhu, Chengluo; Han, Danlu; Liao, Jianwei; Li, Kun; Tang, Xiaoyan; Xie, Qi; Yang, Chengwei; Lai, Jianbin.

Plant Cell ; 2024 Mar 06.

Artigo em Inglês | MEDLINE | ID: mdl-38445983

7.

Utilizing the oxygen-atom trapping effect of Co₃O₄ with oxygen vacancies to promote chlorite activation for water decontamination.

Su, Ruidian; Gao, Yixuan; Chen, Long; Chen, Yi; Li, Nan; Liu, Wen; Gao, Baoyu; Li, Qian.

Proc Natl Acad Sci U S A ; 121(11): e2319427121, 2024 Mar 12.

Artigo em Inglês | MEDLINE | ID: mdl-38442175

8.

Dual modifying of MAVS at lysine 7 by SIRT3-catalyzed deacetylation and SIRT5-catalyzed desuccinylation orchestrates antiviral innate immunity.

Liu, Xing; Zhu, Chunchun; Jia, Shuke; Deng, Hongyan; Tang, Jinhua; Sun, Xueyi; Zeng, Xiaoli; Chen, Xiaoyun; Wang, Zixuan; Liu, Wen; Liao, Qian; Zha, Huangyuan; Cai, Xiaolian; Xiao, Wuhan.

Proc Natl Acad Sci U S A ; 121(17): e2314201121, 2024 Apr 23.

Artigo em Inglês | MEDLINE | ID: mdl-38635631

9.

Targeting the PHF8/YY1 axis suppresses cancer cell growth through modulation of ROS.

Wu, Xiao-Nan; Li, Jia-Yuan; He, Qi; Li, Bo-Qun; He, Yao-Hui; Pan, Xu; Wang, Ming-Yue; Sang, Rui; Ding, Jian-Cheng; Gao, Xiang; Wu, Zhen; Liu, Wen.

Proc Natl Acad Sci U S A ; 121(2): e2219352120, 2024 Jan 09.

Artigo em Inglês | MEDLINE | ID: mdl-38165927

10.

Empagliflozin in Patients with Chronic Kidney Disease.

Herrington, William G; Staplin, Natalie; Wanner, Christoph; Green, Jennifer B; Hauske, Sibylle J; Emberson, Jonathan R; Preiss, David; Judge, Parminder; Mayne, Kaitlin J; Ng, Sarah Y A; Sammons, Emily; Zhu, Doreen; Hill, Michael; Stevens, Will; Wallendszus, Karl; Brenner, Susanne; Cheung, Alfred K; Liu, Zhi-Hong; Li, Jing; Hooi, Lai Seong; Liu, Wen; Kadowaki, Takashi; Nangaku, Masaomi; Levin, Adeera; Cherney, David; Maggioni, Aldo P; Pontremoli, Roberto; Deo, Rajat; Goto, Shinya; Rossello, Xavier; Tuttle, Katherine R; Steubl, Dominik; Petrini, Michaela; Massey, Dan; Eilbracht, Jens; Brueckmann, Martina; Landray, Martin J; Baigent, Colin; Haynes, Richard.

N Engl J Med ; 388(2): 117-127, 2023 01 12.

Artigo em Inglês | MEDLINE | ID: mdl-36331190

11.

CycC1;1-WRKY75 complex-mediated transcriptional regulation of SOS1 controls salt stress tolerance in Arabidopsis.

Lu, Kai-Kai; Song, Ru-Feng; Guo, Jia-Xing; Zhang, Yu; Zuo, Jia-Xin; Chen, Hui-Hui; Liao, Cai-Yi; Hu, Xiao-Yu; Ren, Feng; Lu, Ying-Tang; Liu, Wen-Cheng.

Plant Cell ; 35(7): 2570-2591, 2023 06 26.

Artigo em Inglês | MEDLINE | ID: mdl-37040621

12.

IDO1 Inhibition Promotes Activation of Tumor-intrinsic STAT3 Pathway and Induces Adverse Tumor-protective Effects.

Yu, Longbo; Xu, Lingyan; Chen, Yunjie; Rong, Yicheng; Zou, Yi; Ge, Shushan; Wu, Tiancong; Lai, Yisheng; Xu, Qiang; Guo, Wenjie; Liu, Wen.

J Immunol ; 212(7): 1232-1243, 2024 Apr 01.

Artigo em Inglês | MEDLINE | ID: mdl-38391297

13.

ncRNA- and Pc2 methylation-dependent gene relocation between nuclear structures mediates gene activation programs.

Yang, Liuqing; Lin, Chunru; Liu, Wen; Zhang, Jie; Ohgi, Kenneth A; Grinstein, Jonathan D; Dorrestein, Pieter C; Rosenfeld, Michael G.

Cell ; 147(4): 773-88, 2011 Nov 11.

Artigo em Inglês | MEDLINE | ID: mdl-22078878

14.

Animal models for COVID-19.

Muñoz-Fontela, César; Dowling, William E; Funnell, Simon G P; Gsell, Pierre-S; Riveros-Balta, A Ximena; Albrecht, Randy A; Andersen, Hanne; Baric, Ralph S; Carroll, Miles W; Cavaleri, Marco; Qin, Chuan; Crozier, Ian; Dallmeier, Kai; de Waal, Leon; de Wit, Emmie; Delang, Leen; Dohm, Erik; Duprex, W Paul; Falzarano, Darryl; Finch, Courtney L; Frieman, Matthew B; Graham, Barney S; Gralinski, Lisa E; Guilfoyle, Kate; Haagmans, Bart L; Hamilton, Geraldine A; Hartman, Amy L; Herfst, Sander; Kaptein, Suzanne J F; Klimstra, William B; Knezevic, Ivana; Krause, Philip R; Kuhn, Jens H; Le Grand, Roger; Lewis, Mark G; Liu, Wen-Chun; Maisonnasse, Pauline; McElroy, Anita K; Munster, Vincent; Oreshkova, Nadia; Rasmussen, Angela L; Rocha-Pereira, Joana; Rockx, Barry; Rodríguez, Estefanía; Rogers, Thomas F; Salguero, Francisco J; Schotsaert, Michael; Stittelaar, Koert J; Thibaut, Hendrik Jan; Tseng, Chien-Te.

Nature ; 586(7830): 509-515, 2020 10.

Artigo em Inglês | MEDLINE | ID: mdl-32967005

15.

Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing.

Riva, Laura; Yuan, Shuofeng; Yin, Xin; Martin-Sancho, Laura; Matsunaga, Naoko; Pache, Lars; Burgstaller-Muehlbacher, Sebastian; De Jesus, Paul D; Teriete, Peter; Hull, Mitchell V; Chang, Max W; Chan, Jasper Fuk-Woo; Cao, Jianli; Poon, Vincent Kwok-Man; Herbert, Kristina M; Cheng, Kuoyuan; Nguyen, Tu-Trinh H; Rubanov, Andrey; Pu, Yuan; Nguyen, Courtney; Choi, Angela; Rathnasinghe, Raveen; Schotsaert, Michael; Miorin, Lisa; Dejosez, Marion; Zwaka, Thomas P; Sit, Ko-Yung; Martinez-Sobrido, Luis; Liu, Wen-Chun; White, Kris M; Chapman, Mackenzie E; Lendy, Emma K; Glynne, Richard J; Albrecht, Randy; Ruppin, Eytan; Mesecar, Andrew D; Johnson, Jeffrey R; Benner, Christopher; Sun, Ren; Schultz, Peter G; Su, Andrew I; García-Sastre, Adolfo; Chatterjee, Arnab K; Yuen, Kwok-Yung; Chanda, Sumit K.

Nature ; 586(7827): 113-119, 2020 10.

Artigo em Inglês | MEDLINE | ID: mdl-32707573

16.

Dismissal of RNA Polymerase II Underlies a Large Ligand-Induced Enhancer Decommissioning Program.

Tan, Yuliang; Jin, Chunyu; Ma, Wubin; Hu, Yiren; Tanasa, Bogdan; Oh, Soohwan; Gamliel, Amir; Ma, Qi; Yao, Lu; Zhang, Jie; Ohgi, Kenny; Liu, Wen; Aggarwal, Aneel K; Rosenfeld, Michael G.

Mol Cell ; 71(4): 526-539.e8, 2018 08 16.

Artigo em Inglês | MEDLINE | ID: mdl-30118678

17.

JMJD6 Licenses ERα-Dependent Enhancer and Coding Gene Activation by Modulating the Recruitment of the CARM1/MED12 Co-activator Complex.

Gao, Wei-Wei; Xiao, Rong-Quan; Zhang, Wen-Juan; Hu, Yi-Ren; Peng, Bing-Ling; Li, Wen-Juan; He, Yao-Hui; Shen, Hai-Feng; Ding, Jian-Cheng; Huang, Qi-Xuan; Ye, Tian-Yi; Li, Ying; Liu, Zhi-Ying; Ding, Rong; Rosenfeld, Michael G; Liu, Wen.

Mol Cell ; 70(2): 340-357.e8, 2018 04 19.

Artigo em Inglês | MEDLINE | ID: mdl-29628309

18.

CARM1 hypermethylates the NuRD chromatin remodeling complex to promote cell cycle gene expression and breast cancer development.

Chen, Xue; Huang, Ming-Feng; Fan, Da-Meng; He, Yao-Hui; Zhang, Wen-Juan; Ding, Jian-Cheng; Peng, Bing-Ling; Pan, Xu; Liu, Ya; Du, Jun; Li, Ying; Liu, Zhi-Ying; Xie, Bing-Lan; Kuang, Zhi-Jian; Yi, Jia; Liu, Wen.

Nucleic Acids Res ; 2024 Apr 27.

Artigo em Inglês | MEDLINE | ID: mdl-38676947

19.

A deregulated m⁶A writer complex axis driven by BRD4 confers an epitranscriptomic vulnerability in combined DNA repair-targeted therapy.

Lu, Xiao; Peng, Lichao; Ding, Jiancheng; Li, Yuanpei; Li, Qing; Rao, Mengchen; Shu, Tong; He, Xiaoniu; Liu, Chen; Ye, Jing; Liu, Wen; You, Han.

Proc Natl Acad Sci U S A ; 120(41): e2304534120, 2023 10 10.

Artigo em Inglês | MEDLINE | ID: mdl-37782793

20.

Device-independent quantum randomness-enhanced zero-knowledge proof.

Li, Cheng-Long; Zhang, Kai-Yi; Zhang, Xingjian; Yang, Kui-Xing; Han, Yu; Cheng, Su-Yi; Cui, Hongrui; Liu, Wen-Zhao; Li, Ming-Han; Liu, Yang; Bai, Bing; Dong, Hai-Hao; Zhang, Jun; Ma, Xiongfeng; Yu, Yu; Fan, Jingyun; Zhang, Qiang; Pan, Jian-Wei.

Proc Natl Acad Sci U S A ; 120(45): e2205463120, 2023 Nov 07.

Artigo em Inglês | MEDLINE | ID: mdl-37917793

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