Detalhe da pesquisa
1.
ßOHB Protective Pathways in Aralar-KO Neurons and Brain: An Alternative to Ketogenic Diet.
J Neurosci
; 40(48): 9293-9305, 2020 11 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33087477
2.
Extracellular ATP and glutamate drive pyruvate production and energy demand to regulate mitochondrial respiration in astrocytes.
Glia
; 67(4): 759-774, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30623988
3.
L-Lactate-Mediated Neuroprotection against Glutamate-Induced Excitotoxicity Requires ARALAR/AGC1.
J Neurosci
; 36(16): 4443-56, 2016 Apr 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27098689
4.
Glutamate excitotoxicity and Ca2+-regulation of respiration: Role of the Ca2+ activated mitochondrial transporters (CaMCs).
Biochim Biophys Acta
; 1857(8): 1158-1166, 2016 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-27060251
5.
ARALAR/AGC1 deficiency, a neurodevelopmental disorder with severe impairment of neuronal mitochondrial respiration, does not produce a primary increase in brain lactate.
J Neurochem
; 142(1): 132-139, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28429368
6.
Mitochondrial ATP-Mg/Pi carrier SCaMC-3/Slc25a23 counteracts PARP-1-dependent fall in mitochondrial ATP caused by excitotoxic insults in neurons.
J Neurosci
; 35(8): 3566-81, 2015 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-25716855
7.
Ca(2+) regulation of mitochondrial function in neurons.
Biochim Biophys Acta
; 1837(10): 1617-24, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-24820519
8.
Calcium-regulation of mitochondrial respiration maintains ATP homeostasis and requires ARALAR/AGC1-malate aspartate shuttle in intact cortical neurons.
J Neurosci
; 33(35): 13957-71, 13971a, 2013 Aug 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-23986233
9.
Integrated analysis of transcriptomic and proteomic alterations in mouse models of ALS/FTD identify early metabolic adaptions with similarities to mitochondrial dysfunction disorders.
Amyotroph Lateral Scler Frontotemporal Degener
; 25(1-2): 135-149, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-37779364
10.
AGC1-malate aspartate shuttle activity is critical for dopamine handling in the nigrostriatal pathway.
J Neurochem
; 124(3): 347-62, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23216354
11.
Effect of TP53 deficiency and KRAS signaling on the bioenergetics of colon cancer cells in response to different substrates: A single cell study.
Front Cell Dev Biol
; 10: 893677, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36238683
12.
Deficiency of the mitochondrial transporter of aspartate/glutamate aralar/AGC1 causes hypomyelination and neuronal defects unrelated to myelin deficits in mouse brain.
J Neurosci Res
; 89(12): 2008-17, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21608011
13.
BCL2 and BCL(X)L selective inhibitors decrease mitochondrial ATP production in breast cancer cells and are synthetically lethal when combined with 2-deoxy-D-glucose.
Oncotarget
; 9(40): 26046-26063, 2018 May 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-29899841
14.
Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases.
Cell Death Differ
; 25(3): 542-572, 2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29229998
15.
Altered postnatal development of cortico-hippocampal neuronal electric activity in mice deficient for the mitochondrial aspartate-glutamate transporter.
J Cereb Blood Flow Metab
; 32(2): 306-17, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21934695
16.
Brain glutamine synthesis requires neuronal-born aspartate as amino donor for glial glutamate formation.
J Cereb Blood Flow Metab
; 31(1): 90-101, 2011 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-20736955