1.
Bioorg Med Chem Lett
; 12(22): 3329-32, 2002 Nov 18.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12392744
RESUMO
The synthesis of a number of indole GnRH antagonists is described. Oxidation of the pyridine ring nitrogen, combined with alkylation at the two position, led to a compound with an excellent in vitro activity profile as well as oral bioavailability in both rats and dogs.