Detalhe da pesquisa
1.
In vitro activity of rifabutin against 293 contemporary carbapenem-resistant Acinetobacter baumannii clinical isolates and characterization of rifabutin mode of action and resistance mechanisms.
J Antimicrob Chemother
; 75(12): 3552-3562, 2020 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32869081
2.
A Novel Genome-Editing Platform for Drug-Resistant Acinetobacter baumannii Reveals an AdeR-Unrelated Tigecycline Resistance Mechanism.
Antimicrob Agents Chemother
; 60(12): 7263-7271, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27671072
3.
Design and synthesis of water-soluble prodrugs of rifabutin for intraveneous administration.
Eur J Med Chem
; 238: 114515, 2022 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35691174
4.
Targeting virulence regulation to disarm Acinetobacter baumannii pathogenesis.
Virulence
; 13(1): 1868-1883, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-36261919
5.
The small-molecule SMARt751 reverses Mycobacterium tuberculosis resistance to ethionamide in acute and chronic mouse models of tuberculosis.
Sci Transl Med
; 14(643): eaaz6280, 2022 05 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35507672
6.
Rifabutin for infusion (BV100) for the treatment of severe carbapenem-resistant Acinetobacter baumannii infections.
Drug Discov Today
; 26(9): 2099-2104, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34242796
7.
The Role of OmpR in Bile Tolerance and Pathogenesis of Adherent-Invasive Escherichia coli.
Front Microbiol
; 12: 684473, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34262546
8.
A nutrient-limited screen unmasks rifabutin hyperactivity for extensively drug-resistant Acinetobacter baumannii.
Nat Microbiol
; 5(9): 1134-1143, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32514072
9.
An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria.
Nat Commun
; 11(1): 3184, 2020 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32576824
10.
Inhibitory properties and X-ray crystallographic study of the binding of AR-101, AR-102 and iclaprim in ternary complexes with NADPH and dihydrofolate reductase from Staphylococcus aureus.
Acta Crystallogr D Biol Crystallogr
; 65(Pt 8): 751-7, 2009 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-19622858
11.
In vitro bactericidal activity of iclaprim in human plasma.
Antimicrob Agents Chemother
; 53(10): 4542-4, 2009 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-19651909
12.
Efficacy of iclaprim against wild-type and thymidine kinase-deficient methicillin-resistant Staphylococcus aureus isolates in an in vitro fibrin clot model.
Antimicrob Agents Chemother
; 53(9): 3635-41, 2009 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-19564362
13.
Increased hydrophobic interactions of iclaprim with Staphylococcus aureus dihydrofolate reductase are responsible for the increase in affinity and antibacterial activity.
J Antimicrob Chemother
; 63(4): 687-98, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19211577
14.
Dissecting Colistin Resistance Mechanisms in Extensively Drug-Resistant Acinetobacter baumannii Clinical Isolates.
mBio
; 10(4)2019 07 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-31311879
15.
Antistreptococcal activity of AR-709 compared to that of other agents.
Antimicrob Agents Chemother
; 52(6): 2279-82, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18362189
16.
Dihydrofolate reductase inhibitors as antibacterial agents.
Biochem Pharmacol
; 71(7): 941-8, 2006 Mar 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-16359642
17.
Synthesis and Structure-Activity Relationships of α-Amino-γ-lactone Ketolides: A Novel Class of Macrolide Antibiotics.
ACS Med Chem Lett
; 5(10): 1133-7, 2014 Oct 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-25313326
18.
A novel ketolide class: Synthesis and antibacterial activity of a lead compound.
Bioorg Med Chem Lett
; 17(18): 5265-9, 2007 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17681467
19.
Discovery of novel, highly potent and selective beta-hairpin mimetic CXCR4 inhibitors with excellent anti-HIV activity and pharmacokinetic profiles.
Bioorg Med Chem
; 14(24): 8396-404, 2006 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17010618