Detalhe da pesquisa
1.
PBTK modelling platforms and parameter estimation tools to enable animal-free risk assessment: recommendations from a joint EPAA--EURL ECVAM ADME workshop.
Regul Toxicol Pharmacol
; 68(1): 119-39, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24287156
2.
A novel method to derive a human safety limit for PFOA by gene expression profiling and modelling.
Front Toxicol
; 6: 1368320, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38577564
3.
The probable future of toxicology - probabilistic risk assessment.
ALTEX
; 41(2): 273-281, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38215352
4.
Refinement and calibration of a human PBPK model for the plasticiser, Di-(2-propylheptyl) phthalate (DPHP) using in silico, in vitro and human biomonitoring data.
Front Pharmacol
; 14: 1111433, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36865923
5.
Development, testing, parameterisation, and calibration of a human PBK model for the plasticiser, di (2-ethylhexyl) adipate (DEHA) using in silico, in vitro and human biomonitoring data.
Front Pharmacol
; 14: 1165770, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37033641
6.
Development, testing, parameterisation, and calibration of a human PBPK model for the plasticiser, di-(2-ethylhexyl) terephthalate (DEHTP) using in silico, in vitro and human biomonitoring data.
Front Pharmacol
; 14: 1140852, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36891271
7.
Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010.
Arch Toxicol
; 85(5): 367-485, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21533817
8.
Derivation of a Human In Vivo Benchmark Dose for Bisphenol A from ToxCast In Vitro Concentration Response Data Using a Computational Workflow for Probabilistic Quantitative In Vitro to In Vivo Extrapolation.
Front Pharmacol
; 12: 754408, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-35222005
9.
Derivation of a Human In Vivo Benchmark Dose for Perfluorooctanoic Acid From ToxCast In Vitro Concentration-Response Data Using a Computational Workflow for Probabilistic Quantitative In Vitro to In Vivo Extrapolation.
Front Pharmacol
; 12: 630457, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34045957
10.
Development, Testing, Parameterisation and Calibration of a Human PBPK Model for the Plasticiser, Di-(2-propylheptyl) Phthalate (DPHP) Using in Silico, in vitro and Human Biomonitoring Data.
Front Pharmacol
; 12: 692442, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34539393
11.
Recombinant expression of aryl hydrocarbon receptor for quantitative ligand-binding analysis.
Anal Biochem
; 384(2): 279-87, 2009 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18938125
12.
Development, Testing, Parameterization, and Calibration of a Human Physiologically Based Pharmacokinetic Model for the Plasticizer, Hexamoll® Diisononyl-Cyclohexane-1, 2-Dicarboxylate Using In Silico, In Vitro, and Human Biomonitoring Data.
Front Pharmacol
; 10: 1394, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31849656
13.
Use cases, best practice and reporting standards for metabolomics in regulatory toxicology.
Nat Commun
; 10(1): 3041, 2019 07 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31292445
14.
A Computational Workflow for Probabilistic Quantitative in Vitro to in Vivo Extrapolation.
Front Pharmacol
; 9: 508, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29867507
15.
Editorial: 3Rs-Strategies for reduction and refinement of animal studies.
Front Pharmacol
; 14: 1200965, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37138851
16.
Relationships between tissue levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), mRNAs, and toxicity in the developing male Wistar(Han) rat.
Toxicol Sci
; 99(2): 591-604, 2007 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17656490
17.
Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the developing male Wistar(Han) rat. II: Chronic dosing causes developmental delay.
Toxicol Sci
; 99(1): 224-33, 2007 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-17545211
18.
Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the developing male Wistar(Han) rat. I: No decrease in epididymal sperm count after a single acute dose.
Toxicol Sci
; 99(1): 214-23, 2007 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-17545212
19.
Characterizing uncertainty and variability in physiologically based pharmacokinetic models: state of the science and needs for research and implementation.
Toxicol Sci
; 99(2): 395-402, 2007 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17483121
20.
Editorial: Application of computational tools to health and environmental sciences, Volume II.
Front Pharmacol
; 13: 1102431, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36532722