Detalhe da pesquisa
1.
The translocator protein ligands as mitochondrial functional modulators for the potential anti-Alzheimer agents.
J Enzyme Inhib Med Chem
; 36(1): 831-846, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-33752569
2.
Modulation of SETDB1 activity by APQ ameliorates heterochromatin condensation, motor function, and neuropathology in a Huntington's disease mouse model.
J Enzyme Inhib Med Chem
; 36(1): 856-868, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-33771089
3.
Discovery of N-(1-(3-fluorobenzoyl)-1H-indol-5-yl)pyrazine-2-carboxamide: a novel, selective, and competitive indole-based lead inhibitor for human monoamine oxidase B.
J Enzyme Inhib Med Chem
; 35(1): 1568-1580, 2020 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-32752896
4.
Synthesis and Biological Evaluation of Disubstituted Pyrimidines as Selective 5-HT2C Agonists.
Molecules
; 24(18)2019 Sep 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31491978
5.
Synthesis and evaluation of an orally available "Y"-shaped biaryl peroxisome proliferator-activated receptor δ agonist.
Bioorg Med Chem
; 26(15): 4382-4389, 2018 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30054191
6.
Discovery of non-peptidic small molecule inhibitors of cyclophilin D as neuroprotective agents in Aß-induced mitochondrial dysfunction.
J Comput Aided Mol Des
; 31(10): 929-941, 2017 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-28913661
7.
In silico probing and biological evaluation of SETDB1/ESET-targeted novel compounds that reduce tri-methylated histone H3K9 (H3K9me3) level.
J Comput Aided Mol Des
; 31(10): 877-889, 2017 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-28879500
8.
Nrf2 activator via interference of Nrf2-Keap1 interaction has antioxidant and anti-inflammatory properties in Parkinson's disease animal model.
Neuropharmacology
; 167: 107989, 2020 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32032607
9.
CRISPR-mediated gene correction links the ATP7A M1311V mutations with amyotrophic lateral sclerosis pathogenesis in one individual.
Commun Biol
; 3(1): 33, 2020 01 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31959876
10.
Newly developed reversible MAO-B inhibitor circumvents the shortcomings of irreversible inhibitors in Alzheimer's disease.
Sci Adv
; 5(3): eaav0316, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30906861
11.
Novel LCK/FMS inhibitors based on phenoxypyrimidine scaffold as potential treatment for inflammatory disorders.
Eur J Med Chem
; 141: 657-675, 2017 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29107425
12.
Discovery of thienopyrrolotriazine derivatives to protect mitochondrial function against Aß-induced neurotoxicity.
Eur J Med Chem
; 141: 240-256, 2017 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29031071