Germline mutations of breast cancer susceptibility genes through expanded genetic analysis in unselected Colombian patients.

BACKGROUND: In Colombia and worldwide, breast cancer (BC) is the most frequently diagnosed neoplasia and the leading cause of death from cancer among women. Studies predominantly involve hereditary and familial cases, demonstrating a gap in the literature regarding the identification of germline mutations in unselected patients from Latin-America. Identification of pathogenic/likely pathogenic (P/LP) variants is important for shaping national genetic analysis policies, genetic counseling, and early detection strategies. The present study included 400 women with unselected breast cancer (BC), in whom we analyzed ten genes, using Whole Exome Sequencing (WES), know to confer risk for BC, with the aim of determining the genomic profile of previously unreported P/LP variants in the affected population. Additionally, Multiplex Ligation-dependent Probe Amplification (MLPA) was performed to identify Large Genomic Rearrangements (LGRs) in the BRCA1/2 genes. To ascertain the functional impact of a recurrent intronic variant (ATM c.5496 + 2_5496 + 5delTAAG), a minigene assay was conducted. RESULTS: We ascertained the frequency of P/LP germline variants in BRCA2 (2.5%), ATM (1.25%), BRCA1 (0.75%), PALB2 (0.50%), CHEK2 (0.50%), BARD1 (0.25%), and RAD51D (0.25%) genes in the population of study. P/LP variants account for 6% of the total population analyzed. No LGRs were detected in our study. We identified 1.75% of recurrent variants in BRCA2 and ATM genes. One of them corresponds to the ATM c.5496 + 2_5496 + 5delTAAG. Functional validation of this variant demonstrated a splicing alteration probably modifying the Pincer domain and subsequent protein structure. CONCLUSION: This study described for the first time the genomic profile of ten risk genes in Colombian women with unselected BC. Our findings underscore the significance of population-based research, advocating the consideration of molecular testing in all women with cancer.

HPV-Vaccine Hesitancy in Colombia: A Mixed-Methods Study.

In Colombia, the uptake rate of the HPV vaccine dropped from 96.7% after its introduction in 2013 to 9% in 2020. To identify the behavioural components of HPV-vaccine hesitancy in females aged 15 and under and their families, we conducted a convergent mixed-methods study in which 196 parents/caregivers responded to an online questionnaire and 10 focus groups were held with 13 of these parents/caregivers, and 50 age-eligible girls. The study is novel as it is the first to explore the factors influencing HPV-vaccine hesitancy alongside the COVID vaccine within an integrative model of behaviour change, the capability-opportunity-motivation-behaviour (COM-B) model. We found that COVID-19 has had an impact on the awareness of HPV and HPV vaccination. Lack of information about the vaccination programs, concerns about vaccine safety and the relationship between HPV and sexuality could be related to vaccine hesitancy. Trust in medical recommendations and campaigns focused on the idea that vaccination is a way of protecting daughters from cervical cancer could improve HPV vaccine uptake.

Consensus on the Treatment and Follow-Up for the Nonmetastatic Castration-Resistant Prostate Cancer: A Report From the First Prostate Cancer Consensus Conference for Developing Countries.

PURPOSE: To present a summary of the recommendations for the treatment and follow-up for the biochemical recurrence of castration-resistant prostate cancer (PCa) as acquired through a questionnaire administered at the Prostate Cancer Consensus Conference for Developing Countries. METHODS: A total of 27 questions were identified as relating to this topic. Responses from the clinician were tallied and are presented in percentage format. Topics included the use of imaging in staging, treatment recommendations across different patient scenarios of life expectancy and prostate-specific antigen (PSA) doubling time, and follow-up for nonmetastatic castration-resistant PCa. RESULTS: A consensus agreed that in optimal conditions, positron emission tomography-computed tomography with prostate-specific membrane antigen would be used although in limited resource situations the combined use of CT of the abdomen and pelvic (or pelvic MRI), a bone scan, and a CT of the thorax or chest x-ray was recommended. In cases when PSA levels double in < 10 months, more than 90% of clinicians agreed on the use of apalutamide or enzalutamide, regardless of life expectancy. With a doubling time of more than 10 months, > 54% of experts recommended no treatment independent of life expectancy. More than half of the experts, regardless of resources, recommended follow-up with a physical examination and PSA levels every 3-6 months and imaging only in the case of symptoms. CONCLUSION: The voting results and recommendations presented in this document can be used by physicians to support management for biochemical recurrence of castration-resistant PCa in areas of limited resources. Individual clinical decision making should be supported by available data.

Real-World Effectiveness and Tolerability of Pazopanib as First Targeted Therapy in Metastatic Renal Cell Carcinoma: A Retrospective Chart Review in Latin America.

INTRODUCTION: Pazopanib is approved in Latin America as first targeted therapy for patients with metastatic renal cell carcinoma (mRCC). METHODS: A retrospective chart review of adult patients with mRCC who initiated pazopanib as first targeted therapy between January 2011 and March 2016 was conducted among oncology care centers in Argentina, Brazil, Chile, Colombia, and Mexico. Patient characteristics, treatment patterns, overall survival (OS), progression-free survival (PFS), and adverse events were summarized. RESULTS: A total of 156 charts of patients with mRCC receiving first-line pazopanib were reviewed (29, 54, 27, 28, and 18 patients from Argentina, Brazil, Chile, Colombia, and Mexico, respectively). The mean age at initial mRCC diagnosis was 61.6 years, 73.7% were male, and 51.3% were Hispanic. The median dose of pazopanib was 800 mg and the median time from initial mRCC diagnosis to pazopanib start was 2.2 months. The median time on treatment was 10.0 months. At the time of data extraction, 16.7% of patients remained on pazopanib, with clinical progression listed as the main reason for discontinuation. Subsequent therapy was received by 25.6% of patients; the most common were everolimus (9.6%) and axitinib (5.8%). Overall, median PFS and OS were 10.8 and 16.9 months, respectively, and varied across countries. The most common all-grade adverse events were diarrhea (44.9%), asthenia/fatigue (43.6%), and nausea (28.8%). CONCLUSIONS: Pazopanib was used for first-line mRCC treatment in a clinically diverse patient population across Latin America. Real-world PFS and tolerability were similar to clinical studies of pazopanib. FUNDING: Novartis Pharmaceuticals Corporation, Inc.

Incidente vial relacionado con trabajo en transportadores de pasajeros y carga en Medellín Colombia: el rol de la infraestructura / Work-related crashes suffered by drivers in freight and passengers transportation activities Medellín Colombia: the road infrastructure role

RESUMEN Objetivo Analizar posibles relaciones entre infraestructura y ocurrencia de incidentes viales relacionados con el trabajo en transportadores de pasajeros y carga en Medellín entre el 2010 y el 2014. Métodos Estudio transversal de asociación entre infraestructura de incidentes viales durante el trabajo relacionados con lesiones de conductores, según la base de datos de informes policiales de accidentes de tránsito del 1.° de enero de 2010 al 31 de julio de 2014. Resultados Hubo 102 602 registros de incidentes viales relacionados con trabajo. El análisis multivariado fue posible con 8 516 registros con información completa entre marzo y julio de 2014. Los factores asociados al evento fueron: choque contra otro vehículo (RP 1,31 IC95 1,09-1,57); vías de dos carriles (RP 1,21 IC95 1,14-1,33) y de tres (RP 1,39 IC95 1,09-1,76); ser conductor de 18 a 24 años (RP 1,13 IC95 1,02-1,26); y conducir bajo efecto de alcohol (RP 2,81 IC95 2,42-3,26). Además, fueron identificados mediante análisis de información geográfica algunos puntos críticos de ocurrencia de incidentes viales relacionados con trabajo. Conclusiones Hay una tendencia creciente de incidentes viales relacionados con trabajo en Medellín. Se requiere especial atención al transporte de pasajeros y de carga por su representativo aporte al total de incidentes viales. El monitoreo de la infraestructura y de zonas de mayor incidencia puede ser útil en el diseño de programas de prevención en empresas de transporte.

ABSTRACT Objective To analyze associations between road infrastructure and Work-Related traffic accidents, in Medellin 2010-2014 in freight and passenger drivers. Methods A retrospective cross-sectional study to establish a possible association between road infrastructure and work-related traffic accidents with injuries for the driver in Medellín Colombia, using the Police traffic accident database, from January 2010 to July 2014. Results There were 102 602 records of traffic accidents. The multivariate analysis was conducted with 8516 records with complete information from March to July 2014. The factors associated with injury were: collision with another vehicle (PR 1,31 95CI 1,09-1,57); two-lane roads (PR: 1,21, 95% CI 1,14-1,33) and three-lane roads (PR: 1,39, 95CI 1,091,76); being a driver between 18 and 24 years old (PR 1.13 95 CI 1,02-1,26); and driving under the influence of alcohol (PR: 2,81 95% CI 2,42-3,26). In addition, through analysis of geographic information, critical points of work-related crashes were identified. Conclusion A growing trend of work-related traffic accidents was identified in Medellín. Special attention must be addressed to passenger and cargo transport due to its significant contribution to traffic accidents in the city. The monitoring of infrastructure and areas with the highest inci-dence can be useful in the design of prevention programs in transport companies.

Recomendaciones para el cuidado de pacientes con cáncer y neoplasias hematológicas en el estado de pandemia COVID-19 en Colombia / Care recommendations for patients with cancer and hematological neoplasms amid the COVID-19 pandemic in Colombia

Resumen Ante la pandemia COVID 19, declarada en marzo de 2020 por la Organización Mundial de la Salud (OMS), desde la Asociación Colombiana de Hematología y Oncología (ACHO) hemos venido emitiendo comunicaciones destinadas a orientar a los profesionales de la salud implicados en el tratamiento de pacientes hematológicos y oncológicos. Consideramos importante realizar una nueva actualización dada la fase de mitigación de la pandemia que actualmente estamos enfrentando y ante el planteamiento gubernamental de desdescalonamiento progresivo, de la cuarentena. Estas recomendaciones no pretenden imponer una conducta única pues entendemos que cada caso es particular y debe actuarse individualizando a cada situación específica. Están basadas en documentos emitidos por asociaciones científicas oncológicas y hematológicas reconocidas y son susceptibles de sufrir modificaciones a medida que se disponga de mayor información.

Abstract In response to the Covid-19 pandemic, declared in March 2020 by the World Health Organization (WHO), the Colombian Association of Hematology and Oncology (ACHO) has been issuing communications aimed at providing guidance to health professionals involved in the treatment of hematological and oncological patients. Considering the pandemic mitigation phase we are currently facing, and the government's approach to progressively tapering-off the quarantine, we deem it important to release a new update. These recommendations are not intended to impose a single conduct, since we understand that each case has particular characteristics and therefore it must be acted upon by individualizing each specific situation. The recommendations are based on documents issued by well-known cancer and hematological scientific associations, and are subject to change as more information becomes available.

Nivel de desarrollo de las funciones ejecutivas en estudiantes adolescentes de los colegios públicos de Envigado-Colombia / Development Levei of Executive Functions in Adolescent Students of Public Schools in Envigado - Colombia

Resumen Las funciones Ejecutivas (FE) permiten el control de la actividad cognitiva, afectiva y conductual, y están influenciadas por múltiples factores como el ambiente sociocultural, académico y familiar. Objetivo: identificar el estado actual del desarrollo de las FE en estudiantes adolescentes de las instituciones educativas públicas del municipio de Envigado (Colombia). Método: estudio cuantitativo, descriptivo, de corte transversal, con una muestra aleatoria de 280 estudiantes de undécimo grado de educación secundaria, a quienes se aplicó la Batería Neuropsicológica de Funciones Ejecutivas (BANFE) (Flores-Lázaro, Ostrosky-Solís, & Lozano-Gutiérrez, 2014). Estos datos se correlacionaron con los resultados de las "Prueba Saber 11°, que evalúa el desempeño académico de los estudiantes que se gradúan de secundaria en Colombia. Resultados: más de la mitad de los estudiantes de la muestra presentaron alteraciones leves o severas en el índice de la FE dorsolateral y en la FE global, y se encontraron diferencias estadísticamente significativas entre hombres y mujeres en la FE dorsolateral (U=8304,5; p= 0,029) y la FE global (U=8412,0, p=0,043). Igualmente, se encontró una correlación estadísticamente significativa entre el puntaje de las "Pruebas Saber 11°" y la FE dorsolateral (r=0,32; p<0,001) y la FE global (r=0,30; p<0,001). Conclusión: 65,7% de los estudiantes adolescentes presentan alteración entre leve y severa en el desempeño de las pruebas de las FE, lo cual se vio asociado con las habilidades académicas evaluadas.

Abstract The Executive Functions (FE in Spanish) allow the cognitive, affective and behavioral activity control. They are influenced by multiple factors such as the sociocultural and academic environment, and parent education as well. Objective: to identify the current state of the development of the Executive Functions in teenagers from public educational institutions in Envigado city (Colombia). Method: the study was quantitative, descriptive, and transversal. A random sample of 280 senior secondary-school students in Envigado (Colombia) was taken, the instrument used was the Neuro-psychological Battery of Executive Functions (BANFE in Spanish) (Flores Lázaro, Ostrosky-Solís, & Lozano Gutiérrez, 2014). As well, Saber 11 Test results were compared with corpus due to the fact this test assesses Colombian students' academic performance. Results: more than a half of the sample evidenced minor or severe alterations in FE dorsolateral and global FE, and some meaningful statistically differences between man and women in these components (p<0,05) were found. Equally, it was determined a meaningful statistics correlation among Saber test score, Dorsolateral executive function (p<0,001) and global FE (p<0,001). Conclusion: 65,7% of the subjects showed a low performance level in FE tests, involving academic skills.

Follow-up of the tumor load in patients with de novo chronic myeloid leukemia and in complete cytogenetic remission treated with imatinib in Colombia.

OBJECTIVE: To evaluate the hematological, cytogenetic, and molecular responses in Colombian patients with CML chronic myeloid leukemia (CML) treated with imatinib. METHODS: Two groups of patients, one with the novo diagnostic and another in state of complete cytogenetic remission were followed for 12 months with quantitative PCR evaluations every three months and with chromosomal analysis every 6 months. RESULTS: The group with the novo diagnosis showed 50% of complete cytogenetic remission at 12 months while the other 50% were considered to have primary resistance. Respect the molecular analysis, 10.5% of the patients reached undetectable BCR-ABL transcripts at 12 months. In the complete cytogenetic remission group, 10.6% lost the state of complete cytogenetic remission at 12 months, 50% reached undetectable BCR-ABL transcripts but 10% showed levels higher than 10%, which in our standardization was equal to no molecular response. CONCLUSIONS: Despite having received the conventional dosages of 400 mg/day of imatinib, the cytogenetic and molecular responses obtained in our group of Colombian patients with CML, were lower than those in other international studies.

OBJETIVO: Evaluar las respuestas hematológica, citogenética y molecular en pacientes colombianos con leucemia mieloide crónica tratados con imatinib. MÉTODOS: Dos grupos, uno con diagnóstico de novo y otro en el estado de remisión citogenética completa, se siguieron mediante estudios citogenéticos en médula ósea cada 6 meses y reacción en cadena de la polimerasa cuantitativa (Q-PCR) cada 3 meses. RESULTADOS: En el grupo de novo, el 50% alcanzó el estado de remisión citogenética completa mientras el otro 50% se consideró con Resistencia primaria. Respecto al análisis molecular, 10.5% mostró transcriptos BCR-ABL indetectables. En el grupo de remisión citogenética completa, 10.6% perdió la condición de remisión citogenética completa, en el 50% los transcriptos BCR-ABL fueron indetectables mientras el 10% mostró niveles por encima del 10% considerado como no respuesta molecular, según nuestra estandarización. CONCLUSIÓN: Aunque los pacientes recibieron las dosis convencionales de 400 mg/día de imatinib, las tasas de respuesta citogenética y molecular en los pacientes colombianos fueron menores que las obtenidas en estudios internacionales.

Descripción de las caracteristicas clínicas de las neoplasias mieloproliferativas crónicas (NMPC). Primer informe del registro colombiano de NMPC / Description of the clinical characteristics of chronic myeloproliferative neoplasms (MPNs). First report of the colombian registry of MPNs

Resumen Introducción y objetivos: las neoplasias mieloproliferativas crónicas (NMPC) son relativamente raras, con incidencias que varían entre 0.47-1.03/100 000 habitantes. Se presenta el primer informe del trabajo del registro colombiano de NMPC, cuyo objetivo es describir las características clínicas de estos pacientes en nuestro país. Material y métodos: estudio descriptivo observacional, multicéntrico, retrospectivo y prospectivo en ocho centros del país, de abril de 2013 a diciembre de 2014. Las variables cualitativas se presentan con frecuencias absolutas y relativas; y las cuantitativas se resumen en medidas de tendencia central y dispersión. Resultados: once centros fueron aprobados, ocho ingresaron pacientes. En los primeros 179 casos reportados, 50% eran hombres, la edad promedio al diagnóstico 58.7 años (rango 19-92). Noventa y tres muestran trombocitemia esencial (TE); 55, policitemia vera (PV); y 31, mielofibrosis (MF). El 41% tenía esplenomegalia al diagnóstico; el 20% tuvo complicaciones trombóticas; y 12.85%, sangrado. Sólo en 57.5% se realizó JAK; de ellos, en 53.5% fue positivo, en especial sólo 60% de las PV. El 8% de los casos no tenía estudio de médula ósea, el 29.3% tiene algún grado de fibrosis. El hallazgo más frecuente fue hiperplasia megacariocítica en 59.78%. Más de 50% de pacientes estaban sintomáticos al diagnóstico. Sólo el 11% no recibió tratamiento farmacológico; los más frecuentes fueron hidroxiurea en 149 casos y ASA en 79. Con promedio de seguimiento de 52.6 meses; el 97.21% de los pacientes están vivos. Conclusiones: los hallazgos sugieren que algunas características de las NMPC podrían ser diferentes a lo reportado en otras series, lo que valida la importancia del esfuerzo de recoger información local.

Abstract Introduction and objectives: chronic MPNs are relatively rare, with incidences varying between 0.47-1.03 / 100 000 inhabitants. The first report of the work of the Colombian registry of chronic MPNs, whose objective is to describe the clinical characteristics of these patients in our country, is presented. Materials and methods: descriptive observational, multicenter, retrospective and prospective study in eight centers of the country, from April 2013 to December 2014. Qualitative variables are presented with absolute and relative frequencies, and the quantitative ones are summarized in measures of central tendency and dispersion. Results: eleven centers were approved; 8 admitted patients. In the first 179 cases reported, 50% were men; the average age at diagnosis was 58.7 years (range 19-92). Ninety-three present essential thrombocythemia (ET); 55, polycythemia vera (PV); and 31, myelofibrosis (MF). 41% had splenomegaly at diagnosis; 20% had thrombotic complications, and 12.85%, bleeding. JAK was performed in only 57.5%. Of them, in 53.5% was positive, especially in only 60% of the PV. 8% of the cases had no bone marrow study; 29.3% had some degree of fibrosis. The most frequent finding was megakaryocytic hyperplasia in 59.78%. More than 50% of patients were symptomatic at diagnosis. Only 11% did not receive pharmacological treatment, being the most frequent hydroxyurea in 149 cases and ASA in 79, with an average follow-up of 52.6 months. 97.21% of patients are alive. Conclusions: the findings suggest that some characteristics of chronic MPNs could be different from those reported in other series, which validates the importance of the effort to collect local information.

Escenarios de explotación sexual comercial de niños, niñas y adolescentes, modalidad abierta, Medellín, 2012 / Scenarios of street-based commercial sexual exploitation of children and adolescents, Medellín, 2012 / Cenários de exploração sexual comercial de crianças e adolecentes, modalidade aberta, Medellín, 2012

La explotación sexual de niños, niñas y adolescentes (ESCNNA) es una grave violación los derechos de niños, niñas y adolescentes. En Medellín, existe poca información sobre cuantificación y sectores de ocurrencia del problema, que permita la ejecución de estrategias para su prevención y atención. Objetivo: describir magnitud y ubicación, días y horarios de ocurrencia de la ESCNNA, modalidad abierta, en Medellín y las características de los escenarios donde ocurre. Metodología: Estudio descriptivo, con uso de sistemas de información geográfica y realización de mapas temáticos. Se realizó en tres fases: pre-mapeo, mapeo y validación. Se acudió también a técnicas cualitativas. Resultados: De los 634 tramos visitados, hubo reporte de ESCNNA en 18,9%. Se observó agrupación del fenómeno en 11 lugares de concentración. En éstos lugares confluyen factores contextuales que favorecen la ESCNNA: fallas del alumbrado público; poca presencia estatal y de la policía; microtráfico de drogas; cercanía a bares, hoteles y casas de masajes; permisividad social; acceso a drogas y hospedaje. Conclusión: La georreferenciación de estos sectores y el reconocimiento de los factores contextuales que promueven la problemática resultan de gran importancia para contribuir al control y erradicación de esta situación que vulnera la dignidad de niños, niñas y adolescentes de la ciudad.

Commercial sexual exploitation of children and adolescents (CSECA) is a severe violation of the rights of children and adolescents. In Medellin, data on the quantity and locations where this issue takes place is scarce, and it could be useful for implementing strategies for preventing and addressing this issue. Objective: To describe the magnitude of street-based CSECA along with the places, days, hours and characteristics of the scenarios in which it takes place in Medellín. Methodology: A descriptive study in which geographical information systems where used to draw thematic maps. The study had three stages: pre-mapping, mapping and validation. In addition, qualitative techniques were used. Results: Of the 634 areas visited, 18.9% had reported cases of CSECA. The phenomenon was found to be concentrated in 11 cluster areas exhibiting the following context factors that favor CSECA: problems with street lighting, insufficient presence of the State and the local police, drug trafficking, existence of bars, hotels and massage parlors in the area, social permissiveness, easy access to drugs and lodging. Conclusion: georeferencing these areas and identifying the contextual factors behind this situation is very important if this problem, which violates the rights of children and adolescents, is to be controlled and eradicated.

Introdução: a exploração sexual de crianças e adolescentes (ESCCA) é uma grave violação dos direitos de crianças e adolescentes Em Medellín, há pouca informação sobre a quantificação e setores da ocorrência do problema, que permita a execução de estratégias para sua prevenção e atenção. Objetivo: descrever a magnitude ealocalização, dias e períodos de ocorrência da ESCCA, modalidade aberta, na Medellín e as características dos cenários em que ocorre. Materiais e métodos: estudo descritivo, utilização dos sistemas de informação geográfica e desenvolvimento de mapas temáticos. Realizou-se em três fases: pré-mapeamento, mapeamento e validação. Recorreu-se também a técnicas qualitativas. Resultados: das 634 seções visitadas, houve relatos de ESCA em 18,9%. Observou-se agrupamento do fenômeno em 11 sítios de concentração. Esses locais convergem fatores contextuais que favorecem a ESCA: falhas da iluminação pública; pouca presença estatal e da polícia; microtráfico de drogas; proximidade a bares, hotéis e casas de massagens; permissividade social; acesso a drogas e hospedagem. Conclusão: A georreferenciação desses sectores e o reconhecimento dos fatores contextuais que promovem questões que são de grande importância para ajudar ao controlar e erradicar essa situação que viola a dignidade de crianças e adolescentes na cidade.

Follow-up of the tumor load in patients with de novo chronic myeloid leukemia and in complete cytogenetic remission treated with imatinib in Colombia / Seguimiento de la carga tumoral en pacientes con leucemia mielode crónica de novo y en remisión citogenética completa tratados con imatinib en Colombia

ABSTRACT Objective: To evaluate the hematological, cytogenetic, and molecular responses in Colombian patients with CML chronic myeloid leukemia (CML) treated with imatinib. Methods: Two groups of patients, one with the novo diagnostic and another in state of complete cytogenetic remission were followed for 12 months with quantitative PCR evaluations every three months and with chromosomal analysis every 6 months. Results: The group with the novo diagnosis showed 50% of complete cytogenetic remission at 12 months while the other 50% were considered to have primary resistance. Respect the molecular analysis, 10.5% of the patients reached undetectable BCR-ABL transcripts at 12 months. In the complete cytogenetic remission group, 10.6% lost the state of complete cytogenetic remission at 12 months, 50% reached undetectable BCR-ABL transcripts but 10% showed levels higher than 10%, which in our standardization was equal to no molecular response. Conclusions: Despite having received the conventional dosages of 400 mg/day of imatinib, the cytogenetic and molecular responses obtained in our group of Colombian patients with CML, were lower than those in other international studies.

RESUMEN Objetivo. Evaluar las respuestas hematológica, citogenética y molecular en pacientes colombianos con leucemia mieloide crónica tratados con imatinib. Métodos. Dos grupos, uno con diagnóstico de novo y otro en el estado de remisión citogenética completa, se siguieron mediante estudios citogenéticos en médula ósea cada 6 meses y reacción en cadena de la polimerasa cuantitativa (Q-PCR) cada 3 meses. Resultados. En el grupo de novo, el 50% alcanzó el estado de remisión citogenética completa mientras el otro 50% se consideró con Resistencia primaria. Respecto al análisis molecular, 10.5% mostró transcriptos BCR-ABL indetectables. En el grupo de remisión citogenética completa, 10.6% perdió la condición de remisión citogenética completa, en el 50% los transcriptos BCR-ABL fueron indetectables mientras el 10% mostró niveles por encima del 10% considerado como no respuesta molecular, según nuestra estandarización. Conclusión. Aunque los pacientes recibieron las dosis convencionales de 400 mg/día de imatinib, las tasas de respuesta citogenética y molecular en los pacientes colombianos fueron menores que las obtenidas en estudios internacionales.