Detalhe da pesquisa
1.
Discovery of heterocyclic replacements for the coumarin core of anti-tubercular FadD32 inhibitors.
Bioorg Med Chem Lett
; 28(22): 3529-3533, 2018 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30316633
2.
Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular Activity.
J Med Chem
; 66(22): 15380-15408, 2023 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37948640
3.
Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target.
J Med Chem
; 65(1): 409-423, 2022 01 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34910486
4.
Optimization of Hydantoins as Potent Antimycobacterial Decaprenylphosphoryl-ß-d-Ribose Oxidase (DprE1) Inhibitors.
J Med Chem
; 63(10): 5367-5386, 2020 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-32342688
5.
MymA Bioactivated Thioalkylbenzoxazole Prodrug Family Active against Mycobacterium tuberculosis.
J Med Chem
; 63(9): 4732-4748, 2020 05 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32275415
6.
Exploring the SAR of the ß-Ketoacyl-ACP Synthase Inhibitor GSK3011724A and Optimization around a Genotoxic Metabolite.
ACS Infect Dis
; 6(5): 1098-1109, 2020 05 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32196311
7.
Identification and Profiling of Hydantoins-A Novel Class of Potent Antimycobacterial DprE1 Inhibitors.
J Med Chem
; 61(24): 11221-11249, 2018 12 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30500189
8.
Searching for New Leads for Tuberculosis: Design, Synthesis, and Biological Evaluation of Novel 2-Quinolin-4-yloxyacetamides.
J Med Chem
; 59(14): 6709-28, 2016 07 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-27348630
9.
Design, synthesis, and evaluation of new thiadiazole-based direct inhibitors of enoyl acyl carrier protein reductase (InhA) for the treatment of tuberculosis.
J Med Chem
; 58(2): 613-24, 2015 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-25517015
10.
Release of 50 new, drug-like compounds and their computational target predictions for open source anti-tubercular drug discovery.
PLoS One
; 10(12): e0142293, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26642067
11.
Pulmonary Mycobacterium bovis BCG vaccination confers dose-dependent superior protection compared to that of subcutaneous vaccination.
Clin Vaccine Immunol
; 21(4): 594-7, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24501340