Detalhe da pesquisa
1.
Discovery of novel polyamide-pyrrolobenzodiazepine hybrids for antibody-drug conjugates.
Bioorg Med Chem Lett
; 72: 128876, 2022 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35788036
2.
Development of a Novel DNA Mono-alkylator Platform for Antibody-Drug Conjugates.
Mol Cancer Ther
; 23(4): 541-551, 2024 Apr 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38354416
3.
Site-Specific Dolasynthen Antibody-Drug Conjugates Exhibit Consistent Pharmacokinetic Profiles across a Wide Range of Drug-to-Antibody Ratios.
Mol Cancer Ther
; 23(1): 84-91, 2024 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37774393
4.
Discovery and Optimization of a STING Agonist Platform for Application in Antibody Drug Conjugates.
J Med Chem
; 66(15): 10715-10733, 2023 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37486969
5.
Discovery and Preclinical Characterization of XMT-1660, an Optimized B7-H4-Targeted Antibody-Drug Conjugate for the Treatment of Cancer.
Mol Cancer Ther
; 22(9): 999-1012, 2023 09 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37294948
6.
Naphthol derivatives as TRPV1 inhibitors for the treatment of urinary incontinence.
Bioorg Med Chem Lett
; 21(11): 3354-7, 2011 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21531136
7.
Dolaflexin: A Novel Antibody-Drug Conjugate Platform Featuring High Drug Loading and a Controlled Bystander Effect.
Mol Cancer Ther
; 20(5): 885-895, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33722857
8.
The Dolaflexin-based Antibody-Drug Conjugate XMT-1536 Targets the Solid Tumor Lineage Antigen SLC34A2/NaPi2b.
Mol Cancer Ther
; 20(5): 896-905, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33722858
9.
Antibody drug conjugates for treatment of breast cancer: Novel targets and diverse approaches in ADC design.
Pharmacol Ther
; 181: 126-142, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28757155
10.
A Polymer-Based Antibody-Vinca Drug Conjugate Platform: Characterization and Preclinical Efficacy.
Cancer Res
; 75(16): 3365-72, 2015 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26113086
11.
Design and discovery of small molecules targeting raf-1 kinase.
Curr Pharm Des
; 8(25): 2269-78, 2002.
Artigo
em Inglês
| MEDLINE | ID: mdl-12369855
12.
Recent developments in the discovery of protein kinase inhibitors from the urea class.
Curr Opin Drug Discov Devel
; 7(5): 600-16, 2004 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-15503863
13.
trans,anti,trans-Tetra(spirotetrahydrofuranyl)cyclohexane-1,2-dione. Stereocontrolled Synthesis and Definition of Its Susceptibility to Photoisomerization.
J Org Chem
; 61(21): 7486-7491, 1996 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-11667679
14.
Definition of Several Control Elements Relevant to the Stereodefined Serial Elaboration of Belted Poly(spirotetrahydrofurans) Fitted with a Cyclohexane Core.
J Org Chem
; 61(21): 7492-7507, 1996 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-11667680
15.
Pharmacokinetics and antitumor efficacy of XMT-1001, a novel, polymeric topoisomerase I inhibitor, in mice bearing HT-29 human colon carcinoma xenografts.
Clin Cancer Res
; 18(9): 2591-602, 2012 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22392910
16.
Synthesis and structure-activity relationships of novel IKK-beta inhibitors. Part 2: Improvement of in vitro activity.
Bioorg Med Chem Lett
; 14(15): 4013-7, 2004 Aug 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-15225717
17.
Discovery of novel and selective IKK-beta serine-threonine protein kinase inhibitors. Part 1.
Bioorg Med Chem Lett
; 13(5): 913-8, 2003 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-12617920
18.
Synthesis and structure-activity relationships of novel IKK-beta inhibitors. Part 3: Orally active anti-inflammatory agents.
Bioorg Med Chem Lett
; 14(15): 4019-22, 2004 Aug 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-15225718
19.
Omega-carboxypyridyl substituted ureas as Raf kinase inhibitors: SAR of the amide substituent.
Bioorg Med Chem Lett
; 14(3): 783-6, 2004 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-14741289