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1.
J Org Chem ; 79(10): 4561-8, 2014 May 16.
Artigo em Inglês | MEDLINE | ID: mdl-24749981

RESUMO

The preparation of thioesters through the iron-catalyzed coupling reaction of thiols with aldehydes is described. The reactions were carried out by using tert-butyl hydroperoxide (TBHP) as an oxidant and water as a solvent in most cases. This system is compatible with a variety of functional groups.


Assuntos
Aldeídos/química , Ferro/química , Compostos de Sulfidrila/química , Ésteres do Ácido Sulfúrico/síntese química , terc-Butil Hidroperóxido/química , Catálise , Estrutura Molecular , Oxidantes/química , Solventes/química , Ésteres do Ácido Sulfúrico/química , Água/química
2.
Heliyon ; 10(13): e33475, 2024 Jul 15.
Artigo em Inglês | MEDLINE | ID: mdl-39050457

RESUMO

Background: Primary leiomyosarcoma of the breast was a rare malignant tumor. Due to the extremely low morbidity and insufficient understanding of its imageological characteristics, there was a risk of misdiagnosis. In this case report, we presented the features of conventional US, elastography, automated breast volume scanner (ABVS), computed tomography (CT), and pathological findings of a case of primary leiomyosarcoma of the breast. Case presentation: A 74-year-old woman detected a mass of the left breast by palpation. Both ultrasound and CT revealed a solid mass in the outer quadrant of the left breast. After admission, she underwent a modified radical unilateral mastectomy under general anesthesia (resection of the lesion with left breast reserved). Furthermore, the intraoperative frozen section revealed malignant spindle cells, and the postoperative histopathology revealed primary leiomyosarcoma of the breast. After discharge, the patient was generally in good condition after the procedure and was asked to seek medical treatment in the oncology department. Findings on various imaging examinations and clinical data were carefully evaluated. Additionally, we also reviewed the associated kinds of literature. Conclusion: We reported the features of conventional US, elastography, ABVS, CT, and pathological findings of a rare case of primary leiomyosarcoma of the breast. Overall, our findings indicated that the above-mentioned features generally predict malignancy. However, compared to other malignant breast lesions, the features of this case were not specific enough.

3.
Integr Cancer Ther ; 18: 1534735418823273, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30791738

RESUMO

BACKGROUND: Cancer patients receiving Western medical treatment, frequently seek Traditional Chinese Medicine (TCM) to alleviate adverse effects and prolong survival. OBJECTIVE: This study evaluated the association between the use of TCM and cancer survival rate. Research into the effect of TCM on patient survival is limited, this analysis focused on 3 patterns of TCM use. METHODS: Three retrospective cohorts with different patterns of TCM use were selected from the National Health Insurance Research Database of Taiwan and analyzed. Patients with newly diagnosed cancer between 1997 and 2012 were classified into groups of prediagnosis, postdiagnosis, and continuous TCM use associated with awareness of cancer diagnosis. All demographic and clinical data were analyzed. RESULTS: After propensity score matching, longevity of the postdiagnosis and continuous TCM user was significantly longer than the non-TCM user. The adjusted hazard ratios of death in postdiagnosis and continuous TCM use groups (0.59 and 0.61, respectively) were lower than the non-TCM use group. CONCLUSION: The analysis suggests that cancer patients using TCM in conjunction with Western medical treatment exhibited a higher survival rate than patients not using TCM treatment.


Assuntos
Neoplasias/mortalidade , Neoplasias/terapia , Terapias Complementares/métodos , Feminino , Humanos , Masculino , Medicina Tradicional Chinesa/métodos , Pessoa de Meia-Idade , Pontuação de Propensão , Modelos de Riscos Proporcionais , Estudos Retrospectivos , Taxa de Sobrevida , Taiwan
4.
Zhonghua Gan Zang Bing Za Zhi ; 11(9): 550-1, 2003 Sep.
Artigo em Chinês | MEDLINE | ID: mdl-14552718

RESUMO

OBJECTIVE: To study the relationship between aberrant FHIT transcripts and hepatocellular carcinoma (HCC). METHODS: Reverse transcription-polymerase chain reaction (RT-PCR) and single strand conformational polymorphism (SSCP) assays were used to analyze the transcripts and mutations of FHIT gene in 24 matched tumorous tissues and para-tumorous tissues from patients with HCC and in 4 normal liver tissues. RESULTS: Aberrant FHIT transcripts were observed in 11 out of 24 (46%) tumorous tissues and in 2 (8%) of the matched para-tumorous tissues. CONCLUSION: FHIT aberrant transcripts may play an important role in the pathogenesis of hepatocellular carcinoma.


Assuntos
Hidrolases Anidrido Ácido , Carcinoma Hepatocelular/genética , Neoplasias Hepáticas/genética , Proteínas de Neoplasias/genética , Humanos , Mutação , Polimorfismo Conformacional de Fita Simples , RNA Mensageiro/análise , Reação em Cadeia da Polimerase Via Transcriptase Reversa
5.
Chem Commun (Camb) ; 50(77): 11374-7, 2014 Oct 07.
Artigo em Inglês | MEDLINE | ID: mdl-25122526

RESUMO

A DTBP-promoted metal-free and solvent-free formation of C-Se and C-S bonds through sp(3) C-H functionalization of methyl arenes with diselenides and disulfides is described.

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