Detalhe da pesquisa
1.
Multi-step parallel synthesis enabled optimization of benzofuran derivatives as pan-genotypic non-nucleoside inhibitors of HCV NS5B.
Bioorg Med Chem Lett
; 30(7): 127004, 2020 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32061500
2.
Design and evaluation of novel tetracyclic benzofurans as palm site allosteric inhibitors of HCV NS5B polymerase.
Bioorg Med Chem Lett
; 29(24): 126104, 2019 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30389294
3.
Susceptibilities of genotype 1a, 1b, and 3 hepatitis C virus variants to the NS5A inhibitor elbasvir.
Antimicrob Agents Chemother
; 59(11): 6922-9, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26303801
4.
Virologic resistance analysis from a phase 2 study of MK-5172 combined with pegylated interferon/ribavirin in treatment-naive patients with hepatitis C virus genotype 1 infection.
Clin Infect Dis
; 59(12): 1657-65, 2014 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25266289
5.
MK-5172, a selective inhibitor of hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants.
Antimicrob Agents Chemother
; 56(8): 4161-7, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22615282
6.
Development of potent macrocyclic inhibitors of genotype 3a HCV NS3/4A protease.
Bioorg Med Chem Lett
; 22(23): 7201-6, 2012 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23021993
7.
Development of macrocyclic inhibitors of HCV NS3/4A protease with cyclic constrained P2-P4 linkers.
Bioorg Med Chem Lett
; 22(23): 7207-13, 2012 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23084906
8.
Sustained viral response in a hepatitis C virus-infected chimpanzee via a combination of direct-acting antiviral agents.
Antimicrob Agents Chemother
; 55(2): 937-9, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21115793
9.
MK-7009, a potent and selective inhibitor of hepatitis C virus NS3/4A protease.
Antimicrob Agents Chemother
; 54(1): 305-11, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19841155
10.
A transient cell-based phenotype assay for hepatitis C NS3/4A protease: application to potency determinations of a novel macrocyclic inhibitor against diverse protease sequences isolated from plasma infected with HCV.
J Virol Methods
; 151(2): 301-307, 2008 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-18582955
11.
Development of a New Structural Class of Broadly Acting HCV Non-Nucleoside Inhibitors Leading to the Discovery of MK-8876.
ChemMedChem
; 12(17): 1436-1448, 2017 09 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28741898
12.
A genotype 2b NS5B polymerase with novel substitutions supports replication of a chimeric HCV 1b:2b replicon containing a genotype 1b NS3-5A background.
Antiviral Res
; 69(1): 24-30, 2006 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-16297457
13.
HCV evolutionary genetics of SVR versus virologic failure assessed from the vaniprevir phase III registration trials.
Antiviral Res
; 130: 118-29, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26947564
14.
Vaniprevir plus peginterferon alfa-2b and ribavirin in treatment-naive Japanese patients with hepatitis C virus genotype 1 infection: a randomized phase III study.
J Gastroenterol
; 51(4): 390-403, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26403160
15.
P2-quinazolinones and bis-macrocycles as new templates for next-generation hepatitis C virus NS3/4a protease inhibitors: discovery of MK-2748 and MK-6325.
ChemMedChem
; 10(4): 727-35, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25759009
16.
Discovery of MK-8742: an HCV NS5A inhibitor with broad genotype activity.
ChemMedChem
; 8(12): 1930-40, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24127258
17.
Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor.
ACS Med Chem Lett
; 3(4): 332-6, 2012 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900473
18.
Discovery of MK-1220: A Macrocyclic Inhibitor of Hepatitis C Virus NS3/4A Protease with Improved Preclinical Plasma Exposure.
ACS Med Chem Lett
; 2(3): 207-12, 2011 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900304
19.
Discovery of vaniprevir (MK-7009), a macrocyclic hepatitis C virus NS3/4a protease inhibitor.
J Med Chem
; 53(6): 2443-63, 2010 Mar 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-20163176
20.
Structural basis for resistance of the genotype 2b hepatitis C virus NS5B polymerase to site A non-nucleoside inhibitors.
J Mol Biol
; 390(5): 1048-59, 2009 Jul 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-19505479