Detalhe da pesquisa
1.
Development of 2nd generation aminomethyl spectinomycins that overcome native efflux in Mycobacterium abscessus.
Proc Natl Acad Sci U S A
; 121(2): e2314101120, 2024 Jan 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38165935
2.
Benralizumab does not elicit therapeutic effect in patients with chronic spontaneous urticaria: results from the phase 2b multinational, randomised, double-blind, placebo-controlled ARROYO trial.
Br J Dermatol
; 2024 Feb 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38367194
3.
Benralizumab in children with severe eosinophilic asthma: Pharmacokinetics and long-term safety (TATE study).
Pediatr Allergy Immunol
; 35(3): e14092, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38491795
4.
Model-Based Exposure-Response Assessment for Spectinamide 1810 in a Mouse Model of Tuberculosis.
Antimicrob Agents Chemother
; 65(11): e0174420, 2021 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34424046
5.
Development and Characterization of a Dry Powder Formulation for Anti-Tuberculosis Drug Spectinamide 1599.
Pharm Res
; 36(9): 136, 2019 Jul 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-31321552
6.
The Pharmacokinetics, Safety and Tolerability of Aclidinium Bromide 400 µg Administered by Inhalation as Single and Multiple (Twice Daily) Doses in Healthy Chinese Participants.
Int J Chron Obstruct Pulmon Dis
; 18: 2725-2735, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-38046981
7.
Development of a Minimalistic Physiologically Based Pharmacokinetic (mPBPK) Model for the Preclinical Development of Spectinamide Antibiotics.
Pharmaceutics
; 15(6)2023 Jun 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37376207
8.
Efficacy of a brain-penetrant antiviral in lethal Venezuelan and eastern equine encephalitis mouse models.
Sci Transl Med
; 15(691): eabl9344, 2023 04 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37043558
9.
Colchicine-Binding Site Agent CH-2-77 as a Potent Tubulin Inhibitor Suppressing Triple-Negative Breast Cancer.
Mol Cancer Ther
; 21(7): 1103-1114, 2022 07 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35499388
10.
Use of Real-World Data and Pharmacometric Modeling in Support of Lacosamide Dosing in Pediatric Patients Under 4 Years of Age.
J Clin Pharmacol
; 61(7): 881-888, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33599301
11.
Discovery of N-(3,4-Dimethylphenyl)-4-(4-isobutyrylphenyl)-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinoline-8-sulfonamide as a Potent Dual MDM2/XIAP Inhibitor.
J Med Chem
; 64(4): 1930-1950, 2021 02 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33556244
12.
X-ray Crystallography-Guided Design, Antitumor Efficacy, and QSAR Analysis of Metabolically Stable Cyclopenta-Pyrimidinyl Dihydroquinoxalinone as a Potent Tubulin Polymerization Inhibitor.
J Med Chem
; 64(17): 13072-13095, 2021 09 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34406768
13.
Preclinical Evaluation of Inhalational Spectinamide-1599 Therapy against Tuberculosis.
ACS Infect Dis
; 7(10): 2850-2863, 2021 10 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34546724
14.
Sterilization of Mycobacterium tuberculosis infected samples using methanol preserves anti-tuberculosis drugs for subsequent pharmacological testing studies.
Tuberculosis (Edinb)
; 117: 52-55, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31378268
15.
Comparative pharmacokinetics of spectinamide 1599 after subcutaneous and intrapulmonary aerosol administration in mice.
Tuberculosis (Edinb)
; 114: 119-122, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30711150
16.
Development and validation of a liquid chromatography-mass spectrometry (LC-MS) assay for the determination of the anti-cancer agent N-[2-(dimethylamino)ethyl]-2,6-dimethyl-1-oxo-1,2-dihydrobenzo[b]-1,6-naphthyridine-4-carboxamide (SN 28049).
J Chromatogr B Analyt Technol Biomed Life Sci
; 875(2): 368-72, 2008 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18926778
17.
Primary Lung Dendritic Cell Cultures to Assess Efficacy of Spectinamide-1599 Against Intracellular Mycobacterium tuberculosis.
Front Microbiol
; 9: 1895, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30186246
18.
Alterations in cellular pharmacokinetics and pharmacodynamics of elvitegravir in response to ethanol exposure in HIV-1 infected monocytic (U1) cells.
PLoS One
; 12(2): e0172628, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28231276
19.
Selective cellular uptake and retention of SN 28049, a new DNA-binding topoisomerase II-directed antitumor agent.
Cancer Chemother Pharmacol
; 74(1): 25-35, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24801172
20.
Tumour tissue selectivity in the uptake and retention of SN 28049, a new topoisomerase II-directed anticancer agent.
Cancer Chemother Pharmacol
; 72(5): 1013-22, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24036845