Detalhe da pesquisa
1.
A dispensable paralog of succinate dehydrogenase subunit C mediates standing resistance towards a subclass of SDHI fungicides in Zymoseptoria tritici.
PLoS Pathog
; 15(12): e1007780, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31860693
2.
A novel multiple-stage antimalarial agent that inhibits protein synthesis.
Nature
; 522(7556): 315-20, 2015 06 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26085270
3.
4.
Screening a protein kinase inhibitor library against Plasmodium falciparum.
Malar J
; 16(1): 446, 2017 11 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29115999
5.
Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis.
Nature
; 537(7618): 122, 2016 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27281209
6.
Artificial intelligence in chemistry and drug design.
J Comput Aided Mol Des
; 34(7): 709-715, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32468207
7.
8.
Fast Customization of Chemical Language Models to Out-of-Distribution Data Sets.
Chem Mater
; 35(21): 8806-8815, 2023 Nov 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38027545
9.
Achiral oligoamines as versatile tool for the development of aspartic protease inhibitors.
Bioorg Med Chem
; 16(18): 8574-86, 2008 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18760609
10.
Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode.
ChemMedChem
; 10(11): 1821-36, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26395087
11.
The design and synthesis of potent and selective inhibitors of Trypanosoma brucei glycogen synthase kinase 3 for the treatment of human african trypanosomiasis.
J Med Chem
; 57(18): 7536-49, 2014 Sep 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-25198388
12.
Current challenges and trends in the discovery of agrochemicals.
Science
; 341(6147): 742-6, 2013 Aug 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-23950530
13.
From on-target to off-target activity: identification and optimisation of Trypanosoma brucei GSK3 inhibitors and their characterisation as anti-Trypanosoma brucei drug discovery lead molecules.
ChemMedChem
; 8(7): 1127-37, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23776181
14.
Mutagenesis and functional studies with succinate dehydrogenase inhibitors in the wheat pathogen Mycosphaerella graminicola.
PLoS One
; 7(4): e35429, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22536383
15.
Identification of inhibitors of the Leishmania cdc2-related protein kinase CRK3.
ChemMedChem
; 6(12): 2214-24, 2011 Dec 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-21913331
16.
Nucleophilic catalysis of acylhydrazone equilibration for protein-directed dynamic covalent chemistry.
Nat Chem
; 2(6): 490-7, 2010 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-20489719
17.
Pyrrolidine derivatives as plasmepsin inhibitors: binding mode analysis assisted by molecular dynamics simulations of a highly flexible protein.
ChemMedChem
; 5(3): 443-54, 2010 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20112327
18.
Computer-aided design and synthesis of nonpeptidic plasmepsin II and IV inhibitors.
ChemMedChem
; 3(9): 1323-36, 2008 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-18752222
19.
The potential of P1 site alterations in peptidomimetic protease inhibitors as suggested by virtual screening and explored by the use of C-C-coupling reagents.
ChemMedChem
; 1(4): 445-57, 2006 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-16892380