Detalhe da pesquisa
1.
Large Variation in Brain Exposure of Reference CNS Drugs: a PET Study in Nonhuman Primates.
Int J Neuropsychopharmacol
; 18(10): pyv036, 2015 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25813017
2.
Modelling the endothelial blood-CNS barriers: a method for the production of robust in vitro models of the rat blood-brain barrier and blood-spinal cord barrier.
BMC Neurosci
; 14: 59, 2013 Jun 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-23773766
3.
2-thioxanthines are mechanism-based inactivators of myeloperoxidase that block oxidative stress during inflammation.
J Biol Chem
; 286(43): 37578-89, 2011 Oct 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-21880720
4.
Modelling of the blood-brain barrier in drug discovery and development.
Nat Rev Drug Discov
; 6(8): 650-61, 2007 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-17667956
5.
An in vitro blood-brain barrier model for high throughput (HTS) toxicological screening.
Toxicol In Vitro
; 22(3): 799-811, 2008 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18280105
6.
Mimicking brain tissue binding in an in vitro model of the blood-brain barrier illustrates differences between in vitro and in vivo methods for assessing the rate of brain penetration.
Eur J Pharm Biopharm
; 127: 453-461, 2018 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-29602020
7.
Brain penetration of the novel free radical trapping neuroprotectant NXY-059 in rats subjected to permanent focal ischemia.
Brain Res
; 1072(1): 224-6, 2006 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-16448628
8.
In vitro blood-brain barrier permeability and cerebral endothelial cell uptake of the neuroprotective nitrone compound NXY-059 in normoxic, hypoxic and ischemic conditions.
Brain Res
; 955(1-2): 229-35, 2002 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-12419541
9.
The use of in vitro cell culture models for mechanistic studies and as permeability screens for the blood-brain barrier in the pharmaceutical industry--background and current status in the drug discovery process.
Vascul Pharmacol
; 38(6): 355-64, 2002 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-12529930
10.
Corrigendum to "Mimicking brain tissue binding in an in vitro model of the blood-brain barrier illustrates differences between in vitro and in vivo methods for assessing the rate of brain penetration" [Eur. J. Pharm. Biopharm. 127 (2018) 453-461].
Eur J Pharm Biopharm
; 133: 200-202, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30458954
11.
A simple method for assessing free brain/free plasma ratios using an in vitro model of the blood brain barrier.
PLoS One
; 8(12): e80634, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24312489
12.
Cerebrovascular protection as a possible mechanism for the protective effects of NXY-059 in preclinical models: an in vitro study.
Brain Res
; 1294: 144-52, 2009 Oct 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-19631615
13.
Prediction of drug transport through the blood-brain barrier in vivo: a comparison between two in vitro cell models.
Pharm Res
; 19(7): 976-81, 2002 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-12180550