Detalhe da pesquisa
1.
Human Pharmacokinetic and CYP3A DDI Prediction of GDC-2394 using PBPK Modeling and Biomarker Assessment.
Drug Metab Dispos
; 2024 May 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38811156
2.
Hip resurfacing: case closed? A bibliometric analysis of the past 10 years.
Arch Orthop Trauma Surg
; 144(2): 909-916, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-37792058
3.
Development of an Amorphous Solid Dispersion Formulation for Mitigating Mechanical Instability of Crystalline Form and Improving Bioavailability for Early Phase Clinical Studies.
Mol Pharm
; 20(5): 2452-2464, 2023 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37010134
4.
Disruption of IRE1α through its kinase domain attenuates multiple myeloma.
Proc Natl Acad Sci U S A
; 116(33): 16420-16429, 2019 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31371506
5.
Investigating the Utility of Humanized Pregnane X Receptor-Constitutive Androstane Receptor-CYP3A4/7 Mouse Model to Assess CYP3A-Mediated Induction.
Drug Metab Dispos
; 49(7): 540-547, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33863817
6.
Preclinical Safety Assessment of a Highly Selective and Potent Dual Small-Molecule Inhibitor of CBP/P300 in Rats and Dogs.
Toxicol Pathol
; 48(3): 465-480, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32124659
7.
Unremarkable impact of Oatp inhibition on the liver concentration of fluvastatin, lovastatin and pitavastatin in wild-type and Oatp1a/1b knockout mouse.
Xenobiotica
; 49(5): 602-610, 2019 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-29768081
8.
Preclinical assessment of the ADME, efficacy and drug-drug interaction potential of a novel NAMPT inhibitor.
Xenobiotica
; 49(9): 1063-1077, 2019 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-30257601
9.
Design and synthesis of a biaryl series as inhibitors for the bromodomains of CBP/P300.
Bioorg Med Chem Lett
; 28(1): 15-23, 2018 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29169673
10.
Characterizing the in vitro species differences in N-glucuronidation of a potent pan-PIM inhibitor GNE-924 containing a 3,5-substituted 6-azaindazole.
Xenobiotica
; 48(10): 1021-1027, 2018 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-28845725
11.
Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor 21.
J Biol Chem
; 291(11): 5986-5996, 2016 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26797127
12.
Utility of CYP3A4 and PXR-CAR-CYP3A4/3A7 Transgenic Mouse Models To Assess the Magnitude of CYP3A4 Mediated Drug-Drug Interactions.
Mol Pharm
; 14(5): 1754-1759, 2017 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28345929
13.
Absorption, metabolism and excretion of cobimetinib, an oral MEK inhibitor, in rats and dogs.
Xenobiotica
; 47(1): 50-65, 2017 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-27055783
14.
Rifampin-Mediated Induction of Tamoxifen Metabolism in a Humanized PXR-CAR-CYP3A4/3A7-CYP2D6 Mouse Model.
Drug Metab Dispos
; 44(11): 1736-1741, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27538915
15.
In vitro and in vivo characterization of CYP inhibition by 1-aminobenzotriazole in rats.
Biopharm Drug Dispos
; 37(4): 200-11, 2016 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-26637499
16.
Use of transgenic mouse models to understand the oral disposition and drug-drug interaction potential of cobimetinib, a MEK inhibitor.
Drug Metab Dispos
; 43(6): 864-9, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25813936
17.
Discovery of 3,5-substituted 6-azaindazoles as potent pan-Pim inhibitors.
Bioorg Med Chem Lett
; 25(22): 5258-64, 2015 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26459208
18.
Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility.
Bioorg Med Chem Lett
; 25(3): 529-41, 2015 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25556090
19.
Differential effects of Rifampin and Ketoconazole on the blood and liver concentration of atorvastatin in wild-type and Cyp3a and Oatp1a/b knockout mice.
Drug Metab Dispos
; 42(6): 1067-73, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24671957
20.
Investigations into the mechanisms of pyridine ring cleavage in vismodegib.
Drug Metab Dispos
; 42(3): 343-51, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24389420