Does Health Perception, Dietary Habits and Lifestyle Effect Optimism? A Quantitative and Qualitative Study.

The aim of the study was to investigate the relationship between optimism, general health perception, nutritional habits and lifestyle. A quantitative study was conducted on 500 Greek adults. A standardized questionnaire was used which consisted of the General Health Self-Assessment Questionnaire (GHSAQ), the Life Orientation Test-Revised (GrLOT-R), the dietary habits and lifestyle questionnaire. A qualitative study was conducted through interviews and focus groups. Participants' average score of GrLot-R was 20.47 (±4.017) units. The highest GrLot-R score was statistically correlated to more frequent consumption of fruits, salads, dairy products, olive oil, high-fibre cereals and water and to the lower consumption of canned products. Multivariate analysis showed that optimism is significantly positively predicted by the factors "Vitamin K & A", "Vitamin C", and negatively by "Preservatives." There was also a positive correlation between GrLot-R and GHSAQ. The qualitative study analysis showed that physical exercise, duration/quality of sleeping, family and stress affected participants' optimism. It seems that intrinsic factors as vitamins, preservatives, a healthy lifestyle and extrinsic factors as the family background and the environment that someone is raised, affect the level of optimism.

The Impact of the First Wave of the COVID-19 Pandemic on Patients' Perceptions of Chronic Pain.

PURPOSE: On 10 March 2020, Greece entered an increasingly restrictive 42-day lockdown, in order to contain the first wave of the COVID-19 pandemic. All scheduled appointments and activities of the pain clinics around the country were postponed indefinitely. The aim of this prospective study was to assess the perceived impact of the first wave of the pandemic on pain, quality of life, and access to treatment, during the first austere lockdown in Greece. PATIENTS AND METHODS: In this cross-sectional study, 101 patients suffering from chronic pain completed a structured questionnaire. Levels of depression, anxiety, stress, personal wellbeing, optimism and personality traits were also evaluated, using the Depression, Anxiety and Stress Scale (DASS42), the Ten Item Personality Index (TIPI), the Life Orientation Test-Revised (GrLOT-R) and the Personal Wellbeing Index (PWI). RESULTS: Despite the dramatic decrease in health care visitations before, during and after the imposed lockdown, most patients did not feel that access to pain physicians and medication was significantly affected. Higher levels of stress, anxiety, depression, neuroticism, openness to experience and general satisfaction with life seemed to be important determinant factors in how patients experienced their level, intensity and duration of pain, quality of life and response to medication. CONCLUSION: The effects of the lockdown had a more severe impact on patients than the pandemic itself. For most, the level of their pain was not affected by the pandemic and was affected only slightly by the lockdown. Quality of life, however, was affected formost participants. Both the necessity and the complications of introducing the use of telemedicine to Greek chronic pain patients became evident during the study.

Translation, Adaptation and Initial Validation of Food Allergy Quality of Life Questionnaire: Child form in Greek.

The aim of the study is to determine the reliability and validity of the Greek version of the Food Allergy Quality of life Questionnaire-Child Form (FAQLQ-CF). After linguistic validation, the Greek FAQLQ-CF, Food Allergy Independent Measure (FAIM) and Pediatric Quality of Life Inventory (PedsQL™) were used by a physician to interview children diagnosed with food allergy and aged 8-12 via telephone. Cronbach's alpha was used to evaluate reliability, and factor analysis to assess construct validity. The correlation between FAQLQ-CF and FAIM was moderate (rho=0.509, P<0.001) and internal consistency was strong (Cronbach's alpha 0.905). FAQLQ-CF discriminated well each question's contribution to children's quality of life deterioration (32-80%), each child's quality of life (17-89%), children differing in doing things with others (total score 3.55 vs 2.57, difference =0.98 > minimal clinical importance difference = 0.5; P<0.001), but not children differing in reporting anaphylaxis. The total FAQLQ-CF score correlated with the total PedsQL™ score and with the score of one of PedsQL™ subscales, demonstrating convergent validity. Factor analysis uncovered an underlying structure of four factors, explaining 50% of the variance. We can conclude that Greek FAQLQ-CF is a reliable, valid, discriminant tool for interviewing food allergic children aged 8-12, detecting those in need for immediate care.

Psychometric Properties of the International Personality Item Pool Big-Five Personality Questionnaire for the Greek population.

Goldberg's International Personality Item Pool (IPIP) big-five personality factor markers currently lack validating evidence. The structure of the 50-item IPIP was examined in two different adult samples (total N=811), in each case justifying a 5-factor solution, with only minor discrepancies. Age differences were comparable to previous findings using other inventories. One sample (N=193) also completed additionally another personality measure (the TIPI Short Form). Conscientiousness, extraversion and emotional stability/neuroticism scales of the IPIP were highly correlated with those of the TIPI (r=0.62 to 0.65, P=0.01). Agreeableness and Intellect/Openness scales correlated less strongly (r=0.54 and 0.58 respectively, P=0.01). The IPIP scales have good internal consistency (a=0.88) and relate strongly to major dimensions of personality assessed by the two questionnaires.

Immunotherapy-responsive limbic encephalitis with antibodies to glutamic acid decarboxylase.

Glutamic acid decarboxylase (GAD) has been recently identified as a target of humoral autoimmunity in a small subgroup of patients with non-paraneoplastic limbic encephalitis (NPLE). We present a patient with NPLE and positive anti-GAD antibodies who showed significant improvement after long-term immunotherapy. A 48-year old female was admitted with a two-year history of anterograde amnesia and seizures. Brain MRI revealed bilateral lesions of medial temporal lobes. Screening for anti-neuronal antibodies showed high anti-GAD titers in both serum and cerebrospinal fluid (CSF) with strong evidence of intrathecal production. The patient received treatment with prednisolone and long-term plasma exchange. During a 12-month follow-up, she exhibited complete seizure remission and an improvement in memory and visuo-spatial skills. Anti-GAD antibodies may serve as a useful marker to identify a subset of NPLE patients that respond to immunoregulatory treatment.

Psychometric properties of the Specific Thalassemia Quality of Life Instrument for adults.

BACKGROUND: No specific questionnaire has been developed to assess the health-related quality of life of thalassemia patients. Thus, the main objective of this study was to develop, according to psychometric standards, a self-administered Specific Thalassemia Quality of Life Instrument (STQOLI) for adult patients. METHODS: First, a qualitative phase was conducted to generate items and identify domains using the critical analysis incident technique and a literature review. A list of easily comprehensible, non-redundant items was defined using the Delphi technique and a pilot study on ten thalassemia patients. This phase involved both patients and experts. The second step was a quantitative validation phase comprising a study of 128 thalassemia patients in a single hospital. It was designed to select items, identify dimensions, and measure reliability and internal and concurrent validity. The psychometric and scaling properties of the proposed 41-item Specific Thalassemia Quality of Life Instrument were then assessed among patients recruited from the Thalassemia Unit at the General Hospital of Nikaia, Greece. RESULTS: The final questionnaire had 41 items comprising four main domains and one global item about general health. The factorial structure was satisfactory (loading > 0.40 on each factor of the four domains for all items). Interscale correlations ranged from 0.06 to 0.78, Cronbach's α-coefficients were 0.78 for the psychosocial domain, 0.77 for the chelation domain, 0.72 for the transfusion domain, 0.81 for the disease and symptoms domain, and 0.840 for the total score of the questionnaire. CONCLUSION: The 41-item Specific Thalassemia Quality of Life Instrument seems to be a valid tool for assessing health-related quality of life for patients with thalassemia. More research is needed to explore the universal properties of the questionnaire.