Detalhe da pesquisa
1.
Small-angle x-ray and neutron scattering of MexR and its complex with DNA supports a conformational selection binding model.
Biophys J
; 122(2): 408-418, 2023 01 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-36474441
2.
Methotrexate binds to recombinant thiopurine S-methyltransferase and inhibits enzyme activity after high-dose infusions in childhood leukaemia.
Eur J Clin Pharmacol
; 69(9): 1641-9, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23660772
3.
Structural characteristics determine the cause of the low enzyme activity of two thiopurine S-methyltransferase allelic variants: a biophysical characterization of TPMT*2 and TPMT*5.
Biochemistry
; 51(30): 5912-20, 2012 Jul 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-22747506
4.
Pharmacogenetic studies of thiopurine methyltransferase genotype-phenotype concordance and effect of methotrexate on thiopurine metabolism.
Basic Clin Pharmacol Toxicol
; 128(1): 52-65, 2021 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-32865889
5.
Characterization of a novel sequence variant, TPMT*28, in the human thiopurine methyltransferase gene.
Pharmacogenet Genomics
; 20(11): 700-7, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20881512
6.
Comprehensive study of thiopurine methyltransferase genotype, phenotype, and genotype-phenotype discrepancies in Sweden.
Biochem Pharmacol
; 164: 263-272, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31005613
7.
Methylation of selenocysteine catalysed by thiopurine S-methyltransferase.
Biochim Biophys Acta Gen Subj
; 1863(1): 182-190, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30308221
8.
Redesign of human carbonic anhydrase II for increased esterase activity and specificity towards esters with long acyl chains.
Biochim Biophys Acta
; 1764(10): 1601-6, 2006 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-16996812
9.
In Vitro Protein Stability of Two Naturally Occurring Thiopurine S-Methyltransferase Variants: Biophysical Characterization of TPMT*6 and TPMT*8.
ACS Omega
; 2(8): 4991-4999, 2017 Aug 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-30023734
10.
One amino acid makes a difference-Characterization of a new TPMT allele and the influence of SAM on TPMT stability.
Sci Rep
; 7: 46428, 2017 05 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28462921
11.
[The usefulness of pharmacogenetics for a more individualized treatment. The example thiopurines in inflammatory bowel disease and childhood leukemia]. / Nyttan av farmakogenetik för en mer individualiserad behandling - Exemplet tiopuriner vid inflammatorisk tarmsjukdom och barnleukemi.
Lakartidningen
; 1122015 Jun 30.
Artigo
em Sueco
| MEDLINE | ID: mdl-26126006
12.
Robust and convenient analysis of protein thermal and chemical stability.
Protein Sci
; 24(12): 2055-62, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26402034
13.
A test of proposed rules for helix capping: implications for protein design.
Protein Sci
; 11(3): 516-21, 2002 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-11847274
14.
Critical biophysical properties in the Pseudomonas aeruginosa efflux gene regulator MexR are targeted by mutations conferring multidrug resistance.
Protein Sci
; 19(4): 680-92, 2010 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-20095047
15.
Thermodynamic interrogation of a folding disease. Mutant mapping of position 107 in human carbonic anhydrase II linked to marble brain disease.
Biochemistry
; 47(5): 1288-98, 2008 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-18189416
16.
Denaturant-assisted formation of a stabilizing disulfide bridge from engineered cysteines in nonideal conformations.
Biochemistry
; 44(9): 3487-93, 2005 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-15736958
17.
Circumnavigating misfolding traps in the energy landscape through protein engineering: suppression of molten globule and aggregation in carbonic anhydrase.
Biochemistry
; 43(21): 6803-7, 2004 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15157114
18.
Dramatic stabilization of the native state of human carbonic anhydrase II by an engineered disulfide bond.
Biochemistry
; 41(52): 15867-75, 2002 Dec 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-12501217