RESUMO
OBJECTIVE: To assess the prevalence of mumps antibodies in children and adolescents of Mexico, two years after the introduction of the mumps-containing vaccine MMR. MATERIALS AND METHODS: Evaluation of IgG antibodies with a commercial kit of indirect ELISA. RESULTS: 2 111 children (1-9 years) and 2484 adolescents (10-19 years) were studied. The overall antibody seroprevalence was 70.6% (95% CI 69.3-71.9), being higher in adolescents (83.0%, 95%CI 81.5-84.5) than in children (56.0%, 95%CI: 53.9-58.11) (OR 3.83, 95%CI 3.34-4.39, p=0.0000000). Children 1 to 2 and 6 to 9 years who were part of the target group of mumps vaccination since 1998, they had higher seroprevalence than the group of 3 to 5 years unvaccinated. CONCLUSIONS: Seropositivity in children aged 1 to 2 and 6 to 9 years was probably attributable to vaccination during 1998-2000 and in other age groups to natural exposure related to time elapsed in each birth cohort until the study recruitment.
OBJETIVO: Evaluar la prevalencia de anticuerpos antiparotiditis en niños y adolescentes de México, a dos años de haberse introducido la vacuna SRP. MATERIAL Y MÉTODOS: Se estudiaron 2 111 niños (1-9 años) y 2 484 adolescentes (10-19 años). Se evaluaron anticuerpos IgG con un kit comercial de ELISA indirecto. RESULTADOS: La seroprevalencia fue 70.6% (IC95% 69.3-71.9) y resultó mayor en adolescentes (83.0%, IC95% 81.5-84.5) que en niños (56.0%, IC95% 53.9-58.11) (OR 3.83; IC95% 3.34-4.39, p=0.0000000). Los niños de 1 a 2 y de 6 a 9 años, que a partir de 1998 formaron parte del grupo blanco de vacunación vs parotiditis, tuvieron mayor seroprevalencia que el grupo de 3 a 5 años no vacunado. CONCLUSIONES: La seropositividad en niños de 1 a 2 y de 6 a 9 años fue probablemente atribuible a vacunación durante 1998-2000 y la de otros grupos etarios a exposición natural relacionada con el tiempo transcurrido en cada cohorte de nacimientos hasta el reclutamiento al estudio.
Assuntos
Anticorpos Antivirais/sangue , Imunogenicidade da Vacina , Imunoglobulina G/sangue , Vacina contra Sarampo-Caxumba-Rubéola , Vírus da Caxumba/imunologia , Adolescente , Criança , Pré-Escolar , Ensaio de Imunoadsorção Enzimática , Feminino , Humanos , Imunoglobulina G/imunologia , Masculino , México , Estudos Soroepidemiológicos , VacinaçãoRESUMO
INTRODUCTION: Human papillomavirus (HPV) testing is replacing cytology in primary screening. Its limited specificity demands using a second (triage) test to better identify women at high-risk of cervical disease. Cytology represents the immediate triage but its low sensitivity might hamper HPV testing sensitivity, particularly in low-income and middle-income countries (LMICs), where cytology performance has been suboptimal. The ESTAMPA (EStudio multicéntrico de TAMizaje y triaje de cáncer de cuello uterino con pruebas del virus del PApiloma humano; Spanish acronym) study will: (1) evaluate the performance of different triage techniques to detect cervical precancer and (2) inform on how to implement HPV-based screening programmes in LMIC. METHODS AND ANALYSIS: Women aged 30-64 years are screened with HPV testing and Pap across 12 study centres in Latin America. Screened positives have colposcopy with biopsy and treatment of lesions. Women with no evident disease are recalled 18 months later for another HPV test; those HPV-positive undergo colposcopy with biopsy and treatment as needed. Biological specimens are collected in different visits for triage testing, which is not used for clinical management. The study outcome is histological high-grade squamous intraepithelial or worse lesions (HSIL+) under the lower anogenital squamous terminology. About 50 000 women will be screened and 500 HSIL+ cases detected (at initial and 18 months screening). Performance measures (sensitivity, specificity and predictive values) of triage techniques to detect HSIL+ will be estimated and compared with adjustment by age and study centre. ETHICS AND DISSEMINATION: The study protocol has been approved by the Ethics Committee of the International Agency for Research on Cancer (IARC), of the Pan American Health Organisation (PAHO) and by those in each participating centre. A Data and Safety Monitoring Board (DSMB) has been established to monitor progress of the study, assure participant safety, advice on scientific conduct and analysis and suggest protocol improvements. Study findings will be published in peer-reviewed journals and presented at scientific meetings. TRIAL REGISTRATION NUMBER: NCT01881659.
Assuntos
Alphapapillomavirus/isolamento & purificação , Detecção Precoce de Câncer , Infecções por Papillomavirus/diagnóstico , Triagem , Displasia do Colo do Útero/diagnóstico , Adulto , Colposcopia , Feminino , Humanos , América Latina , Pessoa de Meia-Idade , Neoplasias do Colo do Útero/diagnósticoRESUMO
Resumen: Objetivo: Evaluar la prevalencia de anticuerpos antiparotiditis en niños y adolescentes de México, a dos años de haberse introducido la vacuna SRP. Material y métodos: Se estudiaron 2111 niños (1-9 años) y 2484 adolescentes (10-19 años). Se evaluaron anticuerpos IgG con un kit comercial de ELISA indirecto. Resultados: La seroprevalencia fue 70.6% (IC95% 69.3-71.9) y resultó mayor en adolescentes (83.0%, IC95% 81.5-84.5) que en niños (56.0%, IC95% 53.9-58.11) (OR 3.83; IC95% 3.34-4.39, p=0.0000000). Los niños de 1 a 2 y de 6 a 9 años, que a partir de 1998 formaron parte del grupo blanco de vacunación vs parotiditis, tuvieron mayor seroprevalencia que el grupo de 3 a 5 años no vacunado. Conclusiones: La seropositividad en niños de 1 a 2 y de 6 a 9 años fue probablemente atribuible a vacunación durante 1998-2000 y la de otros grupos etarios a exposición natural relacionada con el tiempo transcurrido en cada cohorte de nacimientos hasta el reclutamiento al estudio.
Abstract: Objective: To assess the prevalence of mumps antibodies in children and adolescents of Mexico, two years after the introduction of the mumps-containing vaccine MMR. Materials and methods: Evaluation of IgG antibodies with a commercial kit of indirect ELISA. Results: 2111 children (1-9 years) and 2484 adolescents (10-19 years) were studied. The overall antibody seroprevalence was 70.6% (95% CI 69.3-71.9), being higher in adolescents (83.0%, 95%CI 81.5-84.5) than in children (56.0%, 95%CI: 53.9-58.11) (OR 3.83, 95%CI 3.34-4.39, p=0.0000000). Children 1 to 2 and 6 to 9 years who were part of the target group of mumps vaccination since 1998, they had higher seroprevalence than the group of 3 to 5 years unvaccinated. Conclusions: Seropositivity in children aged 1 to 2 and 6 to 9 years was probably attributable to vaccination during 1998-2000 and in other age groups to natural exposure related to time elapsed in each birth cohort until the study recruitment.