Detalhe da pesquisa
1.
Antimalarial Activity of Artefenomel Against Asexual Parasites and Transmissible Gametocytes During Experimental Blood-Stage Plasmodium vivax Infection.
J Infect Dis
; 225(6): 1062-1069, 2022 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32479608
2.
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Coadministered Ruxolitinib and Artemether-Lumefantrine in Healthy Adults.
Antimicrob Agents Chemother
; 66(1): e0158421, 2022 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34694880
3.
Parasite Viability as a Measure of In Vivo Drug Activity in Preclinical and Early Clinical Antimalarial Drug Assessment.
Antimicrob Agents Chemother
; 66(7): e0011422, 2022 07 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35727057
4.
Model-Informed Drug Development for Malaria Therapeutics.
Annu Rev Pharmacol Toxicol
; 58: 567-582, 2018 01 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28992431
5.
Parasite-Host Dynamics throughout Antimalarial Drug Development Stages Complicate the Translation of Parasite Clearance.
Antimicrob Agents Chemother
; 65(4)2021 03 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33526486
6.
A Phase 1, Placebo-controlled, Randomized, Single Ascending Dose Study and a Volunteer Infection Study to Characterize the Safety, Pharmacokinetics, and Antimalarial Activity of the Plasmodium Phosphatidylinositol 4-Kinase Inhibitor MMV390048.
Clin Infect Dis
; 71(10): e657-e664, 2020 12 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32239164
7.
Safety and parasite clearance of artemisinin-resistant Plasmodium falciparum infection: A pilot and a randomised volunteer infection study in Australia.
PLoS Med
; 17(8): e1003203, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32822347
8.
DSM265 at 400 Milligrams Clears Asexual Stage Parasites but Not Mature Gametocytes from the Blood of Healthy Subjects Experimentally Infected with Plasmodium falciparum.
Antimicrob Agents Chemother
; 63(4)2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30858218
9.
A Single-Dose Combination Study with the Experimental Antimalarials Artefenomel and DSM265 To Determine Safety and Antimalarial Activity against Blood-Stage Plasmodium falciparum in Healthy Volunteers.
Antimicrob Agents Chemother
; 64(1)2019 12 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31685476
10.
A Randomized Trial Evaluating the Prophylactic Activity of DSM265 Against Preerythrocytic Plasmodium falciparum Infection During Controlled Human Malarial Infection by Mosquito Bites and Direct Venous Inoculation.
J Infect Dis
; 217(5): 693-702, 2018 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29216395
11.
Injectable anti-malarials revisited: discovery and development of new agents to protect against malaria.
Malar J
; 17(1): 402, 2018 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30384848
12.
New developments in anti-malarial target candidate and product profiles.
Malar J
; 16(1): 26, 2017 01 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28086874
13.
Defining the Effectiveness of Antimalarial Chemotherapy: Investigation of the Lag in Parasite Clearance Following Drug Administration.
J Infect Dis
; 214(5): 753-61, 2016 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27252475
14.
Piperaquine Monotherapy of Drug-Susceptible Plasmodium falciparum Infection Results in Rapid Clearance of Parasitemia but Is Followed by the Appearance of Gametocytemia.
J Infect Dis
; 214(1): 105-13, 2016 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27056954
15.
Linking Murine and Human Plasmodium falciparum Challenge Models in a Translational Path for Antimalarial Drug Development.
Antimicrob Agents Chemother
; 60(6): 3669-75, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27044554
16.
Efficacy of OZ439 (artefenomel) against early Plasmodium falciparum blood-stage malaria infection in healthy volunteers.
J Antimicrob Chemother
; 71(9): 2620-7, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27272721
17.
A Phase II pilot trial to evaluate safety and efficacy of ferroquine against early Plasmodium falciparum in an induced blood-stage malaria infection study.
Malar J
; 15: 469, 2016 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-27624471
18.
Pharmacokinetic/pharmacodynamic modelling of the antimalarial effect of Actelion-451840 in an induced blood stage malaria study in healthy subjects.
Br J Clin Pharmacol
; 82(2): 412-21, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27062080
19.
Potent Ex Vivo Activity of Naphthoquine and Methylene Blue against Drug-Resistant Clinical Isolates of Plasmodium falciparum and Plasmodium vivax.
Antimicrob Agents Chemother
; 59(10): 6117-24, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26195523
20.
Tafenoquine plus chloroquine for the treatment and relapse prevention of Plasmodium vivax malaria (DETECTIVE): a multicentre, double-blind, randomised, phase 2b dose-selection study.
Lancet
; 383(9922): 1049-58, 2014 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-24360369