RESUMO
The inclusion complexation behavior, characterization and binding ability of hesperetin with ß-cyclodextrin and its derivatives were investigated in both the solution and solid state by means of XRD, DSC, SEM, (1)H and 2D NMR and UV-vis spectroscopy. The results showed that the water solubility and stability of hesperetin were obviously increased in the inclusion complex with cyclodextrins. This satisfactory water solubility and high stability of the hesperetin/CD complexes will be potentially useful for their application as herbal medicines or healthcare products.
Assuntos
Ciclodextrinas/química , Hesperidina/química , Estabilidade de Medicamentos , Ressonância Magnética Nuclear Biomolecular , SolubilidadeRESUMO
The inclusion complexation behavior, characterization and binding ability of naringenin with ß-cyclodextrin and its derivatives were investigated in both solution and the solid state by means of XRD, DSC, SEM, (1)H and 2D NMR and UV-vis spectroscopy. The results showed that the water solubility and thermal stability of naringenin were obviously increased in the inclusion complex with cyclodextrins. This satisfactory water solubility and high thermal stability of the naringenin/CD complexes will be potentially useful for their application as herbal medicines or healthcare products.
Assuntos
Flavanonas/química , Água/química , beta-Ciclodextrinas/química , Disponibilidade Biológica , Flavanonas/farmacocinética , SolubilidadeRESUMO
The inclusion complexation behavior, characterization and binding ability of alpinetin with hydroxypropyl-ß-cyclodextrin (HPßCD) has been investigated in both solution and the solid state by means of UV-vis spectroscopy, FT-IR, ¹H and 2D NMR, XRD, SEM and DSC. The results showed that the water solubility and stability of alpinetin were obviously increased in the inclusion complex with HPßCD. This satisfactory water solubility and high stability of the alpinetin/HPßCD complex will be potentially useful for its application as herbal medicine or healthcare products.