Detalhe da pesquisa
1.
C-H Cyanation of 6-Ring N-Containing Heteroaromatics.
Chemistry
; 23(59): 14733-14737, 2017 Oct 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28833674
2.
Pyridofuran substituted pyrimidine derivatives as HCV replication (replicase) inhibitors.
Bioorg Med Chem Lett
; 22(15): 5144-9, 2012 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22814211
3.
Synthesis and SAR of geminal substitutions at the C5' carbosugar position of pyrimidine-derived HCV inhibitors.
Bioorg Med Chem Lett
; 22(22): 6967-73, 2012 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23036957
4.
Synthesis and SAR of pyridothiazole substituted pyrimidine derived HCV replication inhibitors.
Bioorg Med Chem Lett
; 22(17): 5652-7, 2012 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22858143
5.
5-Benzothiazole substituted pyrimidine derivatives as HCV replication (replicase) inhibitors.
Bioorg Med Chem Lett
; 22(9): 3229-34, 2012 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22472692
6.
Rings in Clinical Trials and Drugs: Present and Future.
J Med Chem
; 65(13): 8699-8712, 2022 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35730680
7.
Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362.
J Med Chem
; 65(20): 14121-14143, 2022 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-36216349
8.
Sustained viral response in a hepatitis C virus-infected chimpanzee via a combination of direct-acting antiviral agents.
Antimicrob Agents Chemother
; 55(2): 937-9, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21115793
9.
Antiviral efficacy upon administration of a HepDirect prodrug of 2'-C-methylcytidine to hepatitis C virus-infected chimpanzees.
Antimicrob Agents Chemother
; 55(8): 3854-60, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21628542
10.
Modulating Target Protein Biology Through the Re-mapping of Conformational Distributions Using Small Molecules.
Front Chem
; 9: 668186, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34017820
11.
Robust antiviral efficacy upon administration of a nucleoside analog to hepatitis C virus-infected chimpanzees.
Antimicrob Agents Chemother
; 53(3): 926-34, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19075052
12.
Design, synthesis, and structure-activity relationship of novel CCR2 antagonists.
Bioorg Med Chem Lett
; 19(6): 1830-4, 2009 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19237282
13.
Synthesis and biological evaluation of platensimycin analogs.
Bioorg Med Chem Lett
; 19(6): 1623-7, 2009 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19233644
14.
Importance of Rigidity in Designing Small Molecule Drugs To Tackle Protein-Protein Interactions (PPIs) through Stabilization of Desired Conformers.
J Med Chem
; 61(10): 4283-4289, 2018 05 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-29140691
15.
Direct sulfonylation of anilines mediated by visible light.
Chem Sci
; 9(3): 629-633, 2018 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-29629128
16.
Discovery of 3-piperidinyl-1-cyclopentanecarboxamide as a novel scaffold for highly potent CC chemokine receptor 2 antagonists.
J Med Chem
; 50(11): 2609-11, 2007 May 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-17461566
17.
Liver-targeted prodrugs of 2'-C-methyladenosine for therapy of hepatitis C virus infection.
J Med Chem
; 50(16): 3891-6, 2007 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-17636948
18.
Combining Molecular Scaffolds from FDA Approved Drugs: Application to Drug Discovery.
J Med Chem
; 60(5): 1638-1647, 2017 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27935308
19.
Novel, orally bioavailable gamma-aminoamide CC chemokine receptor 2 (CCR2) antagonists.
J Med Chem
; 49(16): 4801-4, 2006 Aug 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-16884289
20.
Synthesis and study of alendronate derivatives as potential prodrugs of alendronate sodium for the treatment of low bone density and osteoporosis.
J Med Chem
; 49(11): 3060-3, 2006 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16722624