Spontaneous regression of the primary lesion of a metastatic maligvant melanoma.

An atypical elderly patient with spontaneous regression of a primary lesion of malignant melanoma is presented. The 12 previously reported cases are also reviewed. The histological diagnosis of spontaneous regression of a melanoma can still be made after the regression appears to be grossly complete. All localized areas of depigmentation, or of scarring, should be biopsied when searching for an "occult" primary.

Vascular thrombosis in the upper extremity. A case report implicating a relationship between trauma, oral contraceptives, and smoking.

PIP: A 40-year old white female who was a heavy smoker and who was on oral contraceptives presented at the Maine Medical Center Emergency Room with widespread vascular thrombosis in the forearm and hand six days after injury. Brachial, ulnar and radial arteriotomies were performed and blood flow was restored to all of the hand except the distal ring finger. The patient was forbidden to smoke but resumed smoking on the 8th postoperative day. Thrombosis rapidly progressed and 4 weeks later she underwent amputation of the ring and little fingers. The widespread thrombosis on the patient's hand was attributed to nicotine which increases peripheral vasoconstriction. Smoking has been associated with increased platelet adhesions and subsequent coagulation. It has also been implicated in occlusive vascular disease of the hand and is said to have a mark effect on both digital perfusion and digital wound healing in a patient with ulnar artery thrombosis. Pills also increase coagulability and contributes to widespread thrombotic disease. Early diagnosis of patient's thrombosis and aggressive management including arteriography would have prevented our patient's thrombosis with its sequelae of loss of 2 digits and cold sensitive hand.^ieng