Detalhe da pesquisa
1.
Discovery of a proneurogenic, neuroprotective chemical.
Cell
; 142(1): 39-51, 2010 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-20603013
2.
Novel orexin receptor agonists based on arene- or pyridine-fused 1,3-dihydro-2H-imidazole-2-imines.
Bioorg Med Chem Lett
; 99: 129624, 2024 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38272190
3.
The structure of importin α and the nuclear localization peptide of ChREBP, and small compound inhibitors of ChREBP-importin α interactions.
Biochem J
; 477(17): 3253-3269, 2020 09 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-32776146
4.
Synthesis and evaluation of analogs of 5'-(((Z)-4-amino-2-butenyl)methylamino)-5'-deoxyadenosine (MDL 73811, or AbeAdo) - An inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity.
Bioorg Med Chem
; 25(20): 5433-5440, 2017 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28807574
5.
Development of proneurogenic, neuroprotective small molecules.
J Am Chem Soc
; 133(5): 1428-37, 2011 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-21210688
6.
Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]oxazolo[2,3-e]indol-4-one-6-carboxylate (COI) alkylation subunit.
Bioorg Med Chem Lett
; 20(6): 1854-7, 2010 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20171886
7.
Total synthesis and evaluation of iso-duocarmycin SA and iso-yatakemycin.
J Am Chem Soc
; 131(3): 1187-94, 2009 Jan 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-19154178
8.
Synthesis and evaluation of a thio analogue of duocarmycin SA.
Bioorg Med Chem Lett
; 19(24): 6962-5, 2009 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19879753
9.
Synthesis and Preliminary Evaluation of Duocarmycin Analogues Incorporating the 1,2,11,11a-Tetrahydrocyclopropa[c]naphtho[2,3-e]indol-4-one (CNI) and 1,2,11,11a-Tetrahydrocyclopropa[c]naphtho[1,2-e]indol-4-one (iso-CNI) Alkylation Subunits.
Tetrahedron
; 65(33): 6591-6599, 2009 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20161204
10.
In silico derived small molecules bind the filovirus VP35 protein and inhibit its polymerase cofactor activity.
J Mol Biol
; 426(10): 2045-58, 2014 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24495995
11.
Potent cytotoxic C-11 modified geldanamycin analogues.
J Med Chem
; 52(10): 3265-73, 2009 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-19405528
12.
Systematic exploration of the structural features of yatakemycin impacting DNA alkylation and biological activity.
J Am Chem Soc
; 129(35): 10858-69, 2007 Sep 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-17691783
13.
Rational design, synthesis, and evaluation of key analogues of CC-1065 and the duocarmycins.
J Am Chem Soc
; 129(45): 14092-9, 2007 Nov 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-17948994
14.
Chemobiosynthesis of novel 6-deoxyerythronolide B analogues by mutation of the loading module of 6-deoxyerythronolide B synthase 1.
Appl Environ Microbiol
; 71(8): 4503-9, 2005 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16085842
15.
Fundamental relationships between structure, reactivity, and biological activity for the duocarmycins and CC-1065.
J Med Chem
; 52(19): 5771-80, 2009 Oct 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-19639994
16.
An additional spirocyclization for duocarmycin SA.
J Am Chem Soc
; 130(49): 16521-3, 2008 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-19554689