Detalhe da pesquisa
1.
Highly efficient genome editing in primary human bronchial epithelial cells differentiated at air-liquid interface.
Eur Respir J
; 55(5)2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32060058
2.
Discovery of (4-Pyrazolyl)-2-aminopyrimidines as Potent and Selective Inhibitors of Cyclin-Dependent Kinase 2.
J Med Chem
; 67(4): 3112-3126, 2024 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38325398
3.
Chemical libraries: How dark is HTS dark matter?
Nat Chem Biol
; 11(12): 904-5, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26479440
4.
Process validation and screen reproducibility in high-throughput screening.
J Biomol Screen
; 14(1): 66-76, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19171922
5.
Design and implementation of high-throughput screening assays.
Methods Mol Biol
; 565: 1-32, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19551355
6.
Nuisance Compounds, PAINS Filters, and Dark Chemical Matter in the GSK HTS Collection.
SLAS Discov
; 23(6): 532-545, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29699447
7.
Applications of CRISPR genome editing technology in drug target identification and validation.
Expert Opin Drug Discov
; 12(6): 541-552, 2017 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-28388235
8.
Critical review of the role of HTS in drug discovery.
Drug Discov Today
; 11(7-8): 277-9, 2006 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-16580969
9.
The effect of triton concentration on the activity of undecaprenyl pyrophosphate synthase inhibitors.
J Biomol Screen
; 8(6): 712-5, 2003 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-14711397
10.
A standard operating procedure for assessing liquid handler performance in high-throughput screening.
J Biomol Screen
; 7(6): 554-69, 2002 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-14599354
11.
Novel antibacterials: a genomics approach to drug discovery.
Curr Drug Targets Infect Disord
; 2(4): 291-308, 2002 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-12570737
12.
Design and implementation of high throughput screening assays.
Methods Mol Biol
; 190: 1-29, 2002.
Artigo
em Inglês
| MEDLINE | ID: mdl-12029816
13.
Design and implementation of high throughput screening assays.
Mol Biotechnol
; 47(3): 270-85, 2011 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-20865348
14.
Impact of high-throughput screening in biomedical research.
Nat Rev Drug Discov
; 10(3): 188-95, 2011 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-21358738
15.
Enhancements of screening collections to address areas of unmet medical need: an industry perspective.
Curr Opin Chem Biol
; 14(3): 289-98, 2010 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-20413343
16.
Ultra high quality uHTS.
Drug Discov Today
; 8(20): 923, 2003 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-14554154
17.
Yin and Yang in medicinal chemistry: what does drug-likeness mean?
Future Med Chem
; 3(5): 505-7, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21526891
18.
Identification of novel isoform-selective inhibitors within class I histone deacetylases.
J Pharmacol Exp Ther
; 307(2): 720-8, 2003 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-12975486
19.
Identification and biological characterization of heterocyclic inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.
J Biol Chem
; 277(41): 38322-7, 2002 Oct 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-12167642