Detalhe da pesquisa
1.
Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys.
Nature
; 531(7594): 381-5, 2016 Mar 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-26934220
2.
Oral GS-5806 activity in a respiratory syncytial virus challenge study.
N Engl J Med
; 371(8): 711-22, 2014 Aug 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-25140957
3.
Antiviral Efficacy of a Respiratory Syncytial Virus (RSV) Fusion Inhibitor in a Bovine Model of RSV Infection.
Antimicrob Agents Chemother
; 59(8): 4889-900, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26055364
4.
The oral nucleoside prodrug GS-5245 is efficacious against SARS-CoV-2 and other endemic, epidemic, and enzootic coronaviruses.
Sci Transl Med
; 16(748): eadj4504, 2024 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38776389
5.
Evaluation of 2'-α-fluorine modified nucleoside phosphonates as potential inhibitors of HCV polymerase.
Bioorg Med Chem Lett
; 23(11): 3354-7, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23639543
6.
Efficacy of the oral nucleoside prodrug GS-5245 (Obeldesivir) against SARS-CoV-2 and coronaviruses with pandemic potential.
bioRxiv
; 2023 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37425890
7.
Discovery of GS-5245 (Obeldesivir), an Oral Prodrug of Nucleoside GS-441524 That Exhibits Antiviral Efficacy in SARS-CoV-2-Infected African Green Monkeys.
J Med Chem
; 66(17): 11701-11717, 2023 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37596939
8.
Phosphoramidate Prodrugs Continue to Deliver, The Journey of Remdesivir (GS-5734) from RSV to SARS-CoV-2.
ACS Med Chem Lett
; 13(3): 338-347, 2022 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35291757
9.
Journey of remdesivir from the inhibition of hepatitis C virus to the treatment of COVID-19.
Antivir Ther
; 27(2): 13596535221082773, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35499114
10.
Subcutaneous remdesivir administration prevents interstitial pneumonia in rhesus macaques inoculated with SARS-CoV-2.
Antiviral Res
; 198: 105246, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35032523
11.
Inhaled remdesivir reduces viral burden in a nonhuman primate model of SARS-CoV-2 infection.
Sci Transl Med
; 14(633): eabl8282, 2022 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34968150
12.
Therapeutic treatment with an oral prodrug of the remdesivir parental nucleoside is protective against SARS-CoV-2 pathogenesis in mice.
Sci Transl Med
; 14(643): eabm3410, 2022 05 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35315683
13.
Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets.
Nat Commun
; 12(1): 6415, 2021 11 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34741049
14.
Therapeutic efficacy of an oral nucleoside analog of remdesivir against SARS-CoV-2 pathogenesis in mice.
bioRxiv
; 2021 Sep 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34545367
15.
Prodrugs of a 1'-CN-4-Aza-7,9-dideazaadenosine C-Nucleoside Leading to the Discovery of Remdesivir (GS-5734) as a Potent Inhibitor of Respiratory Syncytial Virus with Efficacy in the African Green Monkey Model of RSV.
J Med Chem
; 64(8): 5001-5017, 2021 04 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33835812
16.
Discovery of GS-9131: Design, synthesis and optimization of amidate prodrugs of the novel nucleoside phosphonate HIV reverse transcriptase (RT) inhibitor GS-9148.
Bioorg Med Chem
; 18(10): 3606-17, 2010 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20409721
17.
Discovery of GS-9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B.
J Med Chem
; 63(18): 10188-10203, 2020 09 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32407112
18.
Safety, pharmacokinetics and pharmacodynamics of selgantolimod, an oral Toll-like receptor 8 agonist: a Phase Ia study in healthy subjects.
Antivir Ther
; 25(3): 171-180, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32667286
19.
Design, synthesis, and anti-HIV activity of 4'-modified carbocyclic nucleoside phosphonate reverse transcriptase inhibitors.
Bioorg Med Chem
; 17(4): 1739-46, 2009 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19179082
20.
Synthesis and anti-HIV activity of GS-9148 (2'-Fd4AP), a novel nucleoside phosphonate HIV reverse transcriptase inhibitor.
Bioorg Med Chem Lett
; 18(3): 1120-3, 2008 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18164198