Detalhe da pesquisa
1.
Paltusotine, a novel oral once-daily nonpeptide SST2 receptor agonist, suppresses GH and IGF-1 in healthy volunteers.
Pituitary
; 25(2): 328-339, 2022 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-35000098
2.
Pharmacologic Characterization of Valbenazine (NBI-98854) and Its Metabolites.
J Pharmacol Exp Ther
; 361(3): 454-461, 2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28404690
3.
ACROBAT Edge: Safety and Efficacy of Switching Injected SRLs to Oral Paltusotine in Patients With Acromegaly.
J Clin Endocrinol Metab
; 108(5): e148-e159, 2023 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36353760
4.
Discovery of Paltusotine (CRN00808), a Potent, Selective, and Orally Bioavailable Non-peptide SST2 Agonist.
ACS Med Chem Lett
; 14(1): 66-74, 2023 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36655128
5.
Lead optimization of 2-(piperidin-3-yl)-1H-benzimidazoles: identification of 2-morpholin- and 2-thiomorpholin-2-yl-1H-benzimidazoles as selective and CNS penetrating H1-antihistamines for insomnia.
Bioorg Med Chem Lett
; 22(1): 421-6, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22153347
6.
COVID-19: A gender-biased pandemic.
J Oral Maxillofac Pathol
; 26(4): 555-557, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-37082045
7.
Influence of pKa on the biotransformation of indene H1-antihistamines by CYP2D6.
Bioorg Med Chem Lett
; 21(3): 947-51, 2011 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21232954
8.
The discovery and structure-activity relationships of 2-(piperidin-3-yl)-1H-benzimidazoles as selective, CNS penetrating H1-antihistamines for insomnia.
Bioorg Med Chem Lett
; 20(9): 2916-9, 2010 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20347297
9.
Selectivity profiling of novel indene H(1)-antihistamines for the treatment of insomnia.
Bioorg Med Chem Lett
; 20(8): 2629-33, 2010 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20227880
10.
Identification of a novel selective H1-antihistamine with optimized pharmacokinetic properties for clinical evaluation in the treatment of insomnia.
Bioorg Med Chem Lett
; 20(19): 5874-8, 2010 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20800486
11.
Novel benzothiophene H1-antihistamines for the treatment of insomnia.
Bioorg Med Chem Lett
; 20(7): 2316-20, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20188547
12.
A pharmacokinetic evaluation of five H(1) antagonists after an oral and intravenous microdose to human subjects.
Br J Clin Pharmacol
; 67(3): 288-98, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19523012
13.
Role of Cytokeratin-7 in the pathogenesis of odontogenic cysts - an immunohistochemical study.
Med Pharm Rep
; 92(3): 282-287, 2019 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-31460511
14.
Potent and orally bioavailable zwitterion GnRH antagonists with low CYP3A4 inhibitory activity.
Bioorg Med Chem Lett
; 18(11): 3301-5, 2008 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18442910
15.
Identification and characterization of pyrrolidine diastereoisomers as potent functional agonists and antagonists of the human melanocortin-4 receptor.
Bioorg Med Chem Lett
; 18(1): 129-36, 2008 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18032040
16.
Zwitterionic uracil derivatives as potent GnRH receptor antagonists with improved pharmaceutical properties.
Bioorg Med Chem Lett
; 18(16): 4503-7, 2008 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18667310
17.
Design, synthesis, in vitro, and in vivo characterization of phenylpiperazines and pyridinylpiperazines as potent and selective antagonists of the melanocortin-4 receptor.
J Med Chem
; 50(25): 6356-66, 2007 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-17994683
18.
Discovery of 1-[2-[(1S)-(3-dimethylaminopropionyl)amino-2-methylpropyl]-4-methylphenyl]-4-[(2R)-methyl-3-(4-chlorophenyl)-propionyl]piperazine as an orally active antagonist of the melanocortin-4 receptor for the potential treatment of cachexia.
J Med Chem
; 50(22): 5249-52, 2007 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17918824
19.
A thienopyridazinone-based melanin-concentrating hormone receptor 1 antagonist with potent in vivo anorectic properties.
J Med Chem
; 49(13): 3753-6, 2006 Jun 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-16789729
20.
Distribution, metabolism, and excretion of the anti-angiogenic compound SU5416.
Toxicol In Vitro
; 20(2): 154-62, 2006 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-16321501