RESUMO
Anthracyclines containing regimen are widely used in advanced breast cancer. The response to first line chemotherapy varies according to many individual factors and the theoretical response to a given protocol cannot predict the response of a patient. A randomized clinical trial (ERASME) was initiated in order to evaluate the more appropriate first line chemotherapy scheme in advanced breast cancer. Prognostic factors were included in a multiple logistic regression to explain the response after the first 3 chemotherapy courses (monthly FEC). Three factors were found to be statistically significant: adjuvant hormonotherapy, loco-regional metastases, adjuvant adriamycin containing regimen (pejorative prognostic factor). By combining these factors, this statistical model enables us to predict a response rate to a first line chemotherapy from 27 to 87%. Such a model can be taken into account in a decision-making procedure of first line chemotherapy in advanced breast cancer.
Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Neoplasias da Mama/tratamento farmacológico , Idoso , Feminino , Humanos , Pessoa de Meia-Idade , Metástase Neoplásica , Recidiva Local de Neoplasia , Prognóstico , Análise de RegressãoRESUMO
The company of the future is already here, formed by the technological ferment that is transforming all of business. These examples are powerhouses.
Assuntos
Redes de Comunicação de Computadores/tendências , Indústrias/tendências , Comércio/tendências , Redes de Comunicação de Computadores/instrumentação , Difusão de Inovações , Sistemas Pré-Pagos de Saúde/organização & administraçãoAssuntos
Neoplasias/terapia , Dor Intratável/terapia , Adulto , Analgésicos não Narcóticos/classificação , Analgésicos não Narcóticos/uso terapêutico , Analgésicos Opioides/classificação , Analgésicos Opioides/uso terapêutico , Criança , Relação Dose-Resposta a Droga , Esquema de Medicação , Conhecimentos, Atitudes e Prática em Saúde , Humanos , Neoplasias/fisiopatologia , Medição da Dor , Dor Intratável/fisiopatologia , Dor Intratável/psicologia , Cuidados Paliativos , Qualidade da Assistência à Saúde , Qualidade de VidaRESUMO
HLA A and B typing was performed in 86 unrelated obese subjects and in 10 families including at least one parent and one obese sibling. The results in the series of unrelated subjects show no significant difference in antigen frequencies as compared to the control series. However in the 10 families studied, a group of 5 families is characterized by a high penetrance of obesity. In this group, inheritance of obesity seems to be transmitted through a dominant mode, and antigen B 18 appeared 4 times out of 5. The possible existence of a genetic form of obesity is considered in the discussion.