Detalhe da pesquisa
1.
Evaluating the oral delivery of GalNAc-conjugated siRNAs in rodents and non-human primates.
Nucleic Acids Res
; 52(10): 5423-5437, 2024 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38742636
2.
Chirality matters: stereo-defined phosphorothioate linkages at the termini of small interfering RNAs improve pharmacology in vivo.
Nucleic Acids Res
; 50(3): 1221-1240, 2022 02 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34268578
3.
From bench to bedside: Improving the clinical safety of GalNAc-siRNA conjugates using seed-pairing destabilization.
Nucleic Acids Res
; 50(12): 6656-6670, 2022 07 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35736224
4.
Shorter Is Better: The α-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs.
J Am Chem Soc
; 145(36): 19691-19706, 2023 09 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37638886
5.
To Isomerize or not to Isomerize? E/Z Isomers of Cyclic Azobenzene Derivatives and Their Reactivity Upon One-Electron Reduction.
Chemistry
; 29(35): e202300146, 2023 Jun 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-37040130
6.
Overcoming GNA/RNA base-pairing limitations using isonucleotides improves the pharmacodynamic activity of ESC+ GalNAc-siRNAs.
Nucleic Acids Res
; 49(19): 10851-10867, 2021 11 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34648028
7.
Small circular interfering RNAs (sciRNAs) as a potent therapeutic platform for gene-silencing.
Nucleic Acids Res
; 49(18): 10250-10264, 2021 10 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34508350
8.
Role of a "Magic" Methyl: 2'-Deoxy-2'-α-F-2'-ß-C-methyl Pyrimidine Nucleotides Modulate RNA Interference Activity through Synergy with 5'-Phosphate Mimics and Mitigation of Off-Target Effects.
J Am Chem Soc
; 144(32): 14517-14534, 2022 08 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35921401
9.
The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine-Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human.
Drug Metab Dispos
; 50(6): 781-797, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34154993
10.
LC-HRMS screening of per- and polyfluorinated alkyl substances (PFAS) in impregnated paper samples and contaminated soils.
Anal Bioanal Chem
; 414(3): 1217-1225, 2022 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-34240229
11.
Knowledge-augmented face perception: Prospects for the Bayesian brain-framework to align AI and human vision.
Conscious Cogn
; 101: 103301, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35427846
12.
Centyrin ligands for extrahepatic delivery of siRNA.
Mol Ther
; 29(6): 2053-2066, 2021 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33601052
13.
Generation and validation of structurally defined antibody-siRNA conjugates.
Nucleic Acids Res
; 48(10): 5281-5293, 2020 06 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32347936
14.
Investigating the pharmacodynamic durability of GalNAc-siRNA conjugates.
Nucleic Acids Res
; 48(21): 11827-11844, 2020 12 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32808038
15.
Selective, Modular Probes for Thioredoxins Enabled by Rational Tuning of a Unique Disulfide Structure Motif.
J Am Chem Soc
; 143(23): 8791-8803, 2021 06 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34061528
16.
An investigational RNAi therapeutic targeting Factor XII (ALN-F12) for the treatment of hereditary angioedema.
RNA
; 25(2): 255-263, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30463937
17.
Safety evaluation of 2'-deoxy-2'-fluoro nucleotides in GalNAc-siRNA conjugates.
Nucleic Acids Res
; 47(7): 3306-3320, 2019 04 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-30820542
18.
Digging into the roots: understanding direct and indirect drivers of ecosystem service trade-offs in coastal grasslands via plant functional traits.
Environ Monit Assess
; 193(Suppl 1): 271, 2021 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33988759
19.
Cognitive modelling reveals distinct electrophysiological markers of decision confidence and error monitoring.
Neuroimage
; 218: 116963, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32461149
20.
Total Synthesis of the Plant Growth Promoter Auxofuran Featuring a Gold(I) Catalyzed Furan Formation.
J Org Chem
; 85(12): 8203-8208, 2020 06 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-32432864