Detalhe da pesquisa
1.
A Robust and Efficient FRET-Based Assay for Cannabinoid Receptor Ligands Discovery.
Molecules
; 28(24)2023 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38138600
2.
Similarities and differences upon binding of naturally occurring Δ9-tetrahydrocannabinol-derivatives to cannabinoid CB1 and CB2 receptors.
Pharmacol Res
; 174: 105970, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34758399
3.
Novel Antiproliferative Biphenyl Nicotinamide: NMR Metabolomic Study of its Effect on the MCF-7 Cell in Comparison with Cisplatin and Vinblastine.
Molecules
; 25(15)2020 Jul 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-32752035
4.
X-Ray Crystallography and Free Energy Calculations Reveal the Binding Mechanism of A2A Adenosine Receptor Antagonists.
Angew Chem Int Ed Engl
; 59(38): 16536-16543, 2020 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32542862
5.
Structure-Based Design of Potent and Selective Ligands at the Four Adenosine Receptors.
Molecules
; 22(11)2017 Nov 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29125553
6.
Exploring Biginelli-based scaffolds as A2B adenosine receptor antagonists: Unveiling novel structure-activity relationship trends, lead compounds, and potent colorectal anticancer agents.
Biomed Pharmacother
; 173: 116345, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38442670
7.
Microscopy and spectroscopy approaches to study GPCR structure and function.
Br J Pharmacol
; 2023 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38087925
8.
Fluorescence based HTS-compatible ligand binding assays for dopamine D3 receptors in baculovirus preparations and live cells.
Front Mol Biosci
; 10: 1119157, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37006609
9.
Pharmacological insights emerging from the characterization of a large collection of synthetic cannabinoid receptor agonists designer drugs.
Biomed Pharmacother
; 164: 114934, 2023 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-37236027
10.
Development of Fluorescent 4-[4-(3H-Spiro[isobenzofuran-1,4'-piperidin]-1'-yl)butyl]indolyl Derivatives as High-Affinity Probes to Enable the Study of σ Receptors via Fluorescence-Based Techniques.
J Med Chem
; 66(6): 3798-3817, 2023 03 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36919956
11.
N-adamantyl-anthranil amide derivatives: New selective ligands for the cannabinoid receptor subtype 2 (CB2R).
Eur J Med Chem
; 248: 115109, 2023 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36657299
12.
Exploring the Effect of Halogenation in a Series of Potent and Selective A2B Adenosine Receptor Antagonists.
J Med Chem
; 66(1): 890-912, 2023 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36517209
13.
Identification of A2BAR as a potential target in colorectal cancer using novel fluorescent GPCR ligands.
Biomed Pharmacother
; 153: 113408, 2022 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-36076535
14.
A2B adenosine receptor antagonists rescue lymphocyte activity in adenosine-producing patient-derived cancer models.
J Immunother Cancer
; 10(5)2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35580926
15.
Exploring Non-orthosteric Interactions with a Series of Potent and Selective A3 Antagonists.
ACS Med Chem Lett
; 13(2): 243-249, 2022 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35178181
16.
Optimization of 2-Amino-4,6-diarylpyrimidine-5-carbonitriles as Potent and Selective A1 Antagonists.
J Med Chem
; 65(3): 2091-2106, 2022 02 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35068155
17.
Potent and Subtype-Selective Dopamine D2 Receptor Biased Partial Agonists Discovered via an Ugi-Based Approach.
J Med Chem
; 64(12): 8710-8726, 2021 06 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34110150
18.
Identification of V6.51L as a selectivity hotspot in stereoselective A2B adenosine receptor antagonist recognition.
Sci Rep
; 11(1): 14171, 2021 07 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34238993
19.
3,4-Dihydropyrimidin-2(1H)-ones as Antagonists of the Human A2B Adenosine Receptor: Optimization, Structure-Activity Relationship Studies, and Enantiospecific Recognition.
J Med Chem
; 64(1): 458-480, 2021 01 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33372800
20.
Nitrogen-Walk Approach to Explore Bioisosteric Replacements in a Series of Potent A2B Adenosine Receptor Antagonists.
J Med Chem
; 63(14): 7721-7739, 2020 07 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32573250