Detalhe da pesquisa
1.
Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor.
Cell
; 172(1-2): 55-67.e15, 2018 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-29307491
2.
Ligand and G-protein selectivity in the κ-opioid receptor.
Nature
; 617(7960): 417-425, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37138078
3.
Structure-based design of bitopic ligands for the µ-opioid receptor.
Nature
; 613(7945): 767-774, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36450356
4.
Insights into distinct signaling profiles of the µOR activated by diverse agonists.
Nat Chem Biol
; 19(4): 423-430, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36411392
5.
IUPHAR themed review: Opioid efficacy, bias, and selectivity.
Pharmacol Res
; 197: 106961, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37844653
6.
Natural Products for the Treatment of Pain: Chemistry and Pharmacology of Salvinorin A, Mitragynine, and Collybolide.
Biochemistry
; 60(18): 1381-1400, 2021 05 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32930582
7.
Predicted Mode of Binding to and Allosteric Modulation of the µ-Opioid Receptor by Kratom's Alkaloids with Reported Antinociception In Vivo.
Biochemistry
; 60(18): 1420-1429, 2021 05 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33274929
8.
Synthesis and Characterization of Azido Aryl Analogs of IBNtxA for Radio-Photoaffinity Labeling Opioid Receptors in Cell Lines and in Mouse Brain.
Cell Mol Neurobiol
; 41(5): 977-993, 2021 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-32424771
9.
Kratom Alkaloids, Natural and Semi-Synthetic, Show Less Physical Dependence and Ameliorate Opioid Withdrawal.
Cell Mol Neurobiol
; 41(5): 1131-1143, 2021 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-33433723
10.
The antinociceptive effects of a dual kappa-delta opioid receptor agonist in the mouse formalin test.
Behav Pharmacol
; 31(2&3): 174-178, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32168026
11.
12.
Strategy for making safer opioids bolstered.
Nature
; 553(7688): 286-288, 2018 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-32076275
13.
Strategy for making safer opioids bolstered.
Nature
; 553(7688): 286-288, 2018 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-29345640
14.
Pharmacological Characterization of Levorphanol, a G-Protein Biased Opioid Analgesic.
Anesth Analg
; 128(2): 365-373, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29649035
15.
Truncated mu opioid GPCR variant involvement in opioid-dependent and opioid-independent pain modulatory systems within the CNS.
Proc Natl Acad Sci U S A
; 113(13): 3663-8, 2016 Mar 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-26976581
16.
Truncated µ-Opioid Receptors With 6 Transmembrane Domains Are Essential for Opioid Analgesia.
Anesth Analg
; 126(3): 1050-1057, 2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28991118
17.
Synthetic and Receptor Signaling Explorations of the Mitragyna Alkaloids: Mitragynine as an Atypical Molecular Framework for Opioid Receptor Modulators.
J Am Chem Soc
; 138(21): 6754-64, 2016 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27192616
18.
Mediation of buprenorphine analgesia by a combination of traditional and truncated mu opioid receptor splice variants.
Synapse
; 70(10): 395-407, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27223691
19.
Mild, Pd-catalyzed stannylation of radioiodination targets.
Bioorg Med Chem Lett
; 25(8): 1761-1764, 2015 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25777268
20.
Isocyanide-Based Multicomponent Reactions for the Synthesis of Heterocycles.
Molecules
; 21(1): E19, 2015 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-26703561