Detalhe da pesquisa
1.
Phosphoantigens glue butyrophilin 3A1 and 2A1 to activate Vγ9Vδ2 T cells.
Nature
; 621(7980): 840-848, 2023 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-37674084
2.
A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated Vγ9Vδ2 T Cell Activation.
Immunity
; 50(4): 1043-1053.e5, 2019 04 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-30902636
3.
Mycobacterial membrane protein Large 3-like-family proteins in bacteria, protozoa, fungi, plants, and animals: A bioinformatics and structural investigation.
Proteins
; 90(3): 776-790, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34739144
4.
Synthesis of Cyclic Sulfite Diesters and their Evaluation as Sulfur Dioxide (SO2 ) Donors.
Chembiochem
; 21(8): 1201-1205, 2020 04 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31709695
5.
Aspergillus flavus squalene synthase as an antifungal target: Expression, activity, and inhibition.
Biochem Biophys Res Commun
; 512(3): 517-523, 2019 05 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30904161
6.
Complex structures of MoeN5 with substrate analogues suggest sequential catalytic mechanism.
Biochem Biophys Res Commun
; 511(4): 800-805, 2019 04 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-30837154
7.
Bisphosphonate-Generated ATP-Analogs Inhibit Cell Signaling Pathways.
J Am Chem Soc
; 140(24): 7568-7578, 2018 06 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-29787268
8.
"Head-to-Middle" and "Head-to-Tail" cis-Prenyl Transferases: Structure of Isosesquilavandulyl Diphosphate Synthase.
Angew Chem Int Ed Engl
; 57(3): 683-687, 2018 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29215779
9.
Moenomycin Biosynthesis: Structure and Mechanism of Action of the Prenyltransferase MoeN5.
Angew Chem Int Ed Engl
; 55(15): 4716-20, 2016 Apr 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-26954060
10.
Thiol activated prodrugs of sulfur dioxide (SO2) as MRSA inhibitors.
Bioorg Med Chem Lett
; 25(13): 2694-7, 2015 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25981687
11.
Benzosulfones as photochemically activated sulfur dioxide (SO2) donors.
Org Biomol Chem
; 13(8): 2399-406, 2015 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-25563212
12.
Structures of Iridoid Synthase from Cantharanthus roseus with Bound NAD(+) , NADPH, or NAD(+) /10-Oxogeranial: Reaction Mechanisms.
Angew Chem Int Ed Engl
; 54(51): 15478-15482, 2015 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26768532
13.
Investigation into the Mechanism of Action of the Tuberculosis Drug Candidate SQ109 and Its Metabolites and Analogues in Mycobacteria.
J Med Chem
; 66(11): 7553-7569, 2023 06 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37235809
14.
Synthesis and Testing of Analogs of the Tuberculosis Drug Candidate SQ109 against Bacteria and Protozoa: Identification of Lead Compounds against Mycobacterium abscessus and Malaria Parasites.
ACS Infect Dis
; 9(2): 342-364, 2023 02 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36706233
15.
Synthesis and antimycobacterial activity of prodrugs of sulfur dioxide (SO2).
Bioorg Med Chem Lett
; 22(11): 3603-6, 2012 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22572576
16.
In Vivo Efficacy of SQ109 against Leishmania donovani, Trypanosoma spp. and Toxoplasma gondii and In Vitro Activity of SQ109 Metabolites.
Biomedicines
; 10(3)2022 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35327472
17.
A Structural and Bioinformatics Investigation of a Fungal Squalene Synthase and Comparisons with Other Membrane Proteins.
ACS Omega
; 7(26): 22601-22612, 2022 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35811857
18.
The Heptaprenyl Diphosphate Synthase (Coq1) Is the Target of a Lipophilic Bisphosphonate That Protects Mice against Toxoplasma gondii Infection.
mBio
; 13(5): e0196622, 2022 10 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-36129297
19.
Structure, In Vivo Detection, and Antibacterial Activity of Metabolites of SQ109, an Anti-Infective Drug Candidate.
ACS Infect Dis
; 7(8): 2492-2507, 2021 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34279904
20.
COVID-19 and Other Pandemics: How Might They Be Prevented?
ACS Infect Dis
; 6(7): 1563-1566, 2020 07 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32478500