Detalhe da pesquisa
1.
Small molecule targeting of the STAT5/6 Src homology 2 (SH2) domains to inhibit allergic airway disease.
J Biol Chem
; 293(26): 10026-10040, 2018 06 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-29739850
2.
Hydrodehalogenation of alkyl iodides with base-mediated hydrogenation and catalytic transfer hydrogenation: application to the asymmetric synthesis of N-protected α-methylamines.
J Org Chem
; 79(17): 8422-7, 2014 Sep 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-25116734
3.
A phosphopeptide mimetic prodrug targeting the SH2 domain of Stat3 inhibits tumor growth and angiogenesis.
J Exp Ther Oncol
; 10(2): 155-62, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-23350355
4.
Efficient synthesis of apricoxib, CS-706, a selective cyclooxygenase-2 inhibitor, and evaluation of inhibition of prostaglandin E2 production in inflammatory breast cancer cells.
Bioorg Med Chem Lett
; 21(20): 6071-3, 2011 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21903394
5.
Discovery of 6-[(3S,4S)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor.
J Med Chem
; 64(20): 15141-15169, 2021 10 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34643390
6.
Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme.
J Med Chem
; 64(15): 11302-11329, 2021 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34292726
7.
Discovery of IACS-9439, a Potent, Exquisitely Selective, and Orally Bioavailable Inhibitor of CSF1R.
J Med Chem
; 63(17): 9888-9911, 2020 09 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32787110
8.
An enolase inhibitor for the targeted treatment of ENO1-deleted cancers.
Nat Metab
; 2(12): 1413-1426, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33230295
9.
Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib.
Cancer Res
; 80(21): 4840-4853, 2020 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32928921
10.
Crystal structure of unphosphorylated STAT3 core fragment.
Biochem Biophys Res Commun
; 374(1): 1-5, 2008 Sep 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-18433722
11.
Blocking Interleukin (IL)4- and IL13-Mediated Phosphorylation of STAT6 (Tyr641) Decreases M2 Polarization of Macrophages and Protects Against Macrophage-Mediated Radioresistance of Inflammatory Breast Cancer.
Int J Radiat Oncol Biol Phys
; 100(4): 1034-1043, 2018 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29485045
12.
Author Correction: An enolase inhibitor for the targeted treatment of ENO1-deleted cancers.
Nat Metab
; 3(1): 122, 2021 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-33340032
13.
Investigation of the binding determinants of phosphopeptides targeted to the SRC homology 2 domain of the signal transducer and activator of transcription 3. Development of a high-affinity peptide inhibitor.
J Med Chem
; 48(21): 6661-70, 2005 Oct 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-16220982
14.
Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 6 (STAT6) with Cell-Permeable, Phosphatase-Stable Phosphopeptide Mimics Potently Inhibits Tyr641 Phosphorylation and Transcriptional Activity.
J Med Chem
; 58(22): 8970-84, 2015 Nov 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-26506089
15.
Long-Acting Beta Agonists Enhance Allergic Airway Disease.
PLoS One
; 10(11): e0142212, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26605551
16.
Application of triethylsilane and palladium-charcoal-induced reductions in the synthesis of Fmoc-glutamic acid analogues.
Adv Exp Med Biol
; 611: 181-2, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19400150
17.
Model of intermolecular interactions between high affinity phosphopeptides and Stat3.
Adv Exp Med Biol
; 611: 543-4, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19400305
18.
Inhibition of Stat3 by cell-permeable peptidomimetic prodrugs targeted to its SH2 domain.
Adv Exp Med Biol
; 611: 545-6, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19400306
19.
Synthesis and in Vitro Evaluation of a Peptidomimetic Inhibitor Targeting the Src Homology 2 (SH2) Domain of STAT6.
ACS Med Chem Lett
; 5(1): 69-72, 2014 Jan 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900775
20.
STAT3 restrains RANK- and TLR4-mediated signalling by suppressing expression of the E2 ubiquitin-conjugating enzyme Ubc13.
Nat Commun
; 5: 5798, 2014 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25503582