Detalhe da pesquisa
1.
Phase 1 safety, tolerability, pharmacokinetics and pharmacodynamic results of KCL-286, a novel retinoic acid receptor-ß agonist for treatment of spinal cord injury, in male healthy participants.
Br J Clin Pharmacol
; 89(12): 3573-3583, 2023 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37452623
2.
Optimised point estimators for multi-stage single-arm phase II oncology trials.
J Biopharm Stat
; 32(6): 817-831, 2022 11 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35196204
3.
A stochastically curtailed single-arm phase II trial design for binary outcomes.
J Biopharm Stat
; 32(5): 671-691, 2022 09 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35077268
4.
A stochastically curtailed two-arm randomised phase II trial design for binary outcomes.
Pharm Stat
; 20(2): 212-228, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32860470
5.
Designing and evaluating dose-escalation studies made easy: The MoDEsT web app.
Clin Trials
; 17(2): 147-156, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31856600
6.
Admissible multiarm stepped-wedge cluster randomized trial designs.
Stat Med
; 38(7): 1103-1119, 2019 03 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-30402914
7.
Re-formulating Gehan's design as a flexible two-stage single-arm trial.
BMC Med Res Methodol
; 19(1): 22, 2019 01 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-30691398
8.
How to design a dose-finding study using the continual reassessment method.
BMC Med Res Methodol
; 19(1): 18, 2019 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-30658575
9.
Extended and standard duration weight-loss programme referrals for adults in primary care (WRAP): a randomised controlled trial.
Lancet
; 389(10085): 2214-2225, 2017 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28478041
10.
Development process of a consensus-driven CONSORT extension for randomised trials using an adaptive design.
BMC Med
; 16(1): 210, 2018 11 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-30442137
11.
Adaptive designs in clinical trials: why use them, and how to run and report them.
BMC Med
; 16(1): 29, 2018 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-29490655
12.
A randomized controlled crossover trial evaluating differential responses to antihypertensive drugs (used as mono- or dual therapy) on the basis of ethnicity: The comparIsoN oF Optimal Hypertension RegiMens; part of the Ancestry Informative Markers in HYpertension program-AIM-HY INFORM trial.
Am Heart J
; 204: 102-108, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30092411
13.
Group sequential clinical trial designs for normally distributed outcome variables.
Stata J
; 18(2): 416-431, 2018 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35125974
14.
Blinded and unblinded sample size reestimation in crossover trials balanced for period.
Biom J
; 60(5): 917-933, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30073679
15.
Blinded and unblinded sample size reestimation procedures for stepped-wedge cluster randomized trials.
Biom J
; 60(5): 903-916, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30073685
16.
Toxicity-dependent feasibility bounds for the escalation with overdose control approach in phase I cancer trials.
Stat Med
; 36(16): 2499-2513, 2017 Jul 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28295513
17.
Modelling semi-attributable toxicity in dual-agent phase I trials with non-concurrent drug administration.
Stat Med
; 36(2): 225-241, 2017 01 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-26891942
18.
Group sequential designs for stepped-wedge cluster randomised trials.
Clin Trials
; 14(5): 507-517, 2017 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-28653550
19.
Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial.
PLoS Med
; 13(10): e1002139, 2016 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-27727279
20.
Do single-arm trials have a role in drug development plans incorporating randomised trials?
Pharm Stat
; 15(2): 143-51, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26609689