Detalhe da pesquisa
1.
C-2 phenyl replacements to obtain potent quinoline-based Staphylococcus aureus NorA inhibitors.
J Enzyme Inhib Med Chem
; 35(1): 584-597, 2020 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-31992093
2.
Structural Modifications of the Quinolin-4-yloxy Core to Obtain New Staphylococcus aureus NorA Inhibitors.
Int J Mol Sci
; 21(19)2020 Sep 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32987835
3.
1,2,4-Triazolo[1,5-a]pyrimidines as a Novel Class of Inhibitors of the HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity.
Molecules
; 25(5)2020 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32151066
4.
Co-crystal structure determination and cellular evaluation of 1,4-dihydropyrazolo[4,3-c] [1,2] benzothiazine 5,5-dioxide p38α MAPK inhibitors.
Biochem Biophys Res Commun
; 511(3): 579-586, 2019 04 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30824186
5.
From cycloheptathiophene-3-carboxamide to oxazinone-based derivatives as allosteric HIV-1 ribonuclease H inhibitors.
J Enzyme Inhib Med Chem
; 34(1): 55-74, 2019 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-30362381
6.
Accounting for target flexibility and water molecules by docking to ensembles of target structures: the HCV NS5B palm site I inhibitors case study.
J Chem Inf Model
; 54(2): 481-97, 2014 Feb 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-23952658
7.
Exploiting the anti-HIV 6-desfluoroquinolones to design multiple ligands.
Bioorg Med Chem
; 22(17): 4658-66, 2014 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25127466
8.
Small Molecule Drugs Targeting Viral Polymerases.
Pharmaceuticals (Basel)
; 17(5)2024 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38794231
9.
Synthetically accessible de novo design using reaction vectors: Application to PARP1 inhibitors.
Mol Inform
; 43(4): e202300183, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38258328
10.
Broad-Spectrum Anti-Flavivirus Activity and Chemistry of Compounds Containing Sulfur and Oxygen Chalcogens.
Curr Med Chem
; 30(21): 2396-2420, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-35702779
11.
Functionalized sulfonyl anthranilic acid derivatives inhibit replication of all the four dengue serotypes.
Eur J Med Chem
; 252: 115283, 2023 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36965228
12.
A cellular screening platform, stably expressing DENV2 NS5, defines a novel anti-DENV mechanism of action of Apigenin based on STAT2 activation.
Virology
; 583: 1-13, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37060797
13.
Pyridobenzothiazole derivatives as new chemotype targeting the HCV NS5B polymerase.
Bioorg Med Chem
; 20(2): 866-76, 2012 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22197397
14.
Virucidal Activity of the Pyridobenzothiazolone Derivative HeE1-17Y against Enveloped RNA Viruses.
Viruses
; 14(6)2022 05 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-35746629
15.
New C-6 functionalized quinoline NorA inhibitors strongly synergize with ciprofloxacin against planktonic and biofilm growing resistant Staphylococcus aureus strains.
Eur J Med Chem
; 241: 114656, 2022 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35963131
16.
Discovery of 2-Phenylquinolines with Broad-Spectrum Anti-coronavirus Activity.
ACS Med Chem Lett
; 13(5): 855-864, 2022 May 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35571875
17.
Sustainable, three-component, one-pot procedure to obtain active anti-flavivirus agents.
Eur J Med Chem
; 210: 112992, 2021 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33208235
18.
From Quinoline to Quinazoline-Based S. aureus NorA Efflux Pump Inhibitors by Coupling a Focused Scaffold Hopping Approach and a Pharmacophore Search.
ChemMedChem
; 16(19): 3044-3059, 2021 10 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34032014
19.
Synthesis and characterization of 1,2,4-triazolo[1,5-a]pyrimidine-2-carboxamide-based compounds targeting the PA-PB1 interface of influenza A virus polymerase.
Eur J Med Chem
; 209: 112944, 2021 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33328103
20.
Modulating microRNA Processing: Enoxacin, the Progenitor of a New Class of Drugs.
J Med Chem
; 63(21): 12275-12289, 2020 11 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32672457