Detalhe da pesquisa
1.
Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65.
Nature
; 527(7579): 477-83, 2015 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-26550826
2.
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells.
Nat Chem Biol
; 7(8): 566-74, 2011 Jul 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-21743462
3.
Structure-Based Design of a Chemical Probe Set for the 5-HT5A Serotonin Receptor.
J Med Chem
; 65(5): 4201-4217, 2022 03 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35195401
4.
Fentanyl-related designer drugs W-18 and W-15 lack appreciable opioid activity in vitro and in vivo.
JCI Insight
; 2(22)2017 11 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-29202454
5.
Structure-Based Discovery of New Antagonist and Biased Agonist Chemotypes for the Kappa Opioid Receptor.
J Med Chem
; 60(7): 3070-3081, 2017 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28339199
6.
Discovery of a neuroprotective chemical, (S)-N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-6-methoxypyridin-2-amine [(-)-P7C3-S243], with improved druglike properties.
J Med Chem
; 57(9): 3746-54, 2014 May 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24697290
7.
Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs.
Nat Commun
; 5: 4355, 2014 Jul 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-25008467
8.
Identification of human Ether-à-go-go related gene modulators by three screening platforms in an academic drug-discovery setting.
Assay Drug Dev Technol
; 8(6): 727-42, 2010 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21158687
9.
Improvement of pharmacological properties of irreversible thyroid receptor coactivator binding inhibitors.
J Med Chem
; 52(13): 3892-901, 2009 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-19469546