Detalhe da pesquisa
1.
A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis.
Nature
; 546(7658): 376-380, 2017 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28562588
2.
Comprehensive physicochemical, pharmacokinetic and activity profiling of anti-TB agents.
J Antimicrob Chemother
; 70(3): 857-67, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25587994
3.
Perspective: Challenges and opportunities in TB drug discovery from phenotypic screening.
Bioorg Med Chem
; 23(16): 5087-97, 2015 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25577708
4.
A novel F(420) -dependent anti-oxidant mechanism protects Mycobacterium tuberculosis against oxidative stress and bactericidal agents.
Mol Microbiol
; 87(4): 744-55, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23240649
5.
Drug discovery for parasitic diseases: powered by technology, enabled by pharmacology, informed by clinical science.
Trends Parasitol
; 39(4): 260-271, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36803572
6.
Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections.
Science
; 380(6652): 1349-1356, 2023 06 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-37384702
7.
Opportunities and Challenges in Developing a Cryptosporidium Controlled Human Infection Model for Testing Antiparasitic Agents.
ACS Infect Dis
; 7(5): 959-968, 2021 05 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33822577
8.
Use-case scenarios for an anti-Cryptosporidium therapeutic.
PLoS Negl Trop Dis
; 15(3): e0009057, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33705395
9.
Benzoheterocyclic Oxime Carbamates Active against Mycobacterium tuberculosis: Synthesis, Structure-Activity Relationship, Metabolism, and Biology Triaging.
J Med Chem
; 64(13): 9444-9457, 2021 07 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34138573
10.
Innovations in Addressing Pediatric Diarrhea in Low Resource Settings.
ACS Infect Dis
; 6(1): 14-24, 2020 01 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31612701
11.
Setting Our Sights on Infectious Diseases.
ACS Infect Dis
; 6(1): 3-13, 2020 01 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31808676
12.
Synthesis and antitubercular activity of 7-(R)- and 7-(S)-methyl-2-nitro-6-(S)-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazines, analogues of PA-824.
Bioorg Med Chem Lett
; 18(7): 2256-62, 2008 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18358721
13.
Safe and effective treatments are needed for cryptosporidiosis, a truly neglected tropical disease.
BMJ Glob Health
; 8(8)2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37541693
14.
Development of a Cytopathic Effect-Based Phenotypic Screening Assay against Cryptosporidium.
ACS Infect Dis
; 4(4): 635-645, 2018 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-29341586
15.
A monoclonal antibody that inhibits mycobacterial DNA gyrase by a novel mechanism.
Nucleic Acids Res
; 33(10): 3085-94, 2005.
Artigo
em Inglês
| MEDLINE | ID: mdl-15930158
16.
The impact of genomics on discovering drugs against infectious diseases.
Microbes Infect
; 8(6): 1654-61, 2006 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-16690340
17.
Structure-activity relationships at the 5-position of thiolactomycin: an intact (5R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli.
J Med Chem
; 49(1): 159-71, 2006 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-16392800
18.
Cryptosporidiosis Drug Discovery: Opportunities and Challenges.
ACS Infect Dis
; 2(8): 530-7, 2016 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27626293
19.
Structure activity relationships of 4-hydroxy-2-pyridones: A novel class of antituberculosis agents.
Eur J Med Chem
; 106: 144-56, 2015 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26544629
20.
Pyrrolo[3,4-c]pyridine-1,3(2H)-diones: A Novel Antimycobacterial Class Targeting Mycobacterial Respiration.
J Med Chem
; 58(23): 9371-81, 2015 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26551248