RESUMO
The aim of this study was to evaluate the effect of biofunctionalization with two TGF-ß1 inhibitor peptides, P17 and P144, on osseointegration of CP-Ti dental implants. A total of 36 implants (VEGA, Klockner®) with 3.5 × 8 mm internal connection were used in this study, divided in three groups: (1) control group (n = 12), (2) implants which surfaces were biofunctionalized with P17 peptide inhibitor (n = 12), (3) implants with surfaces biofunctionalized by P144 peptide (n = 12). Three implants, one from each group, were inserted in both hemimandibles of 6 beagle dogs, 2 months after tooth extraction. Two animals were sacrificed at 2, 4 and 8 weeks post implant insertion, respectively. The samples were analyzed by Backscattering Scanning Electron Microscopy (BS-SEM) and histological analysis. Histomorphometric analysis of bone to implant contact (BIC), peri-implant bone fraction (BF) and interthread bone (IB) were carried out. Bone formation around implants measured by quantitative analysis, BS-SEM, was significantly higher in the P17-biofunctionalized implants, 4 and 8 weeks after the implantation. Histomorphometric analysis of BIC, BF and IB showed higher values in the P17-biofunctionalized group at initial stages of healing (2 weeks) and early osseointegration both at 4 and 8 weeks. For P144 biofunctionalized implants, the histomorphometric values obtained are also higher than control group. Accordingly, better results in the experimental groups were proven both by the quantitative and the qualitative analysis. Surface biofunctionalization with TGF-ß1 inhibitor peptides, P17 and P144, resulted in better quantitative and qualitative parameters relative to implant osseointegration.
Assuntos
Materiais Revestidos Biocompatíveis/farmacologia , Implantes Dentários , Osseointegração/efeitos dos fármacos , Fragmentos de Peptídeos/química , Peptídeos/química , Receptores de Fatores de Crescimento Transformadores beta/química , Animais , Materiais Revestidos Biocompatíveis/química , Implantação Dentária Endóssea , Planejamento de Prótese Dentária , Cães , Implantes Experimentais , Masculino , Mandíbula/patologia , Mandíbula/cirurgia , Teste de Materiais , Osteogênese/efeitos dos fármacos , Propriedades de Superfície/efeitos dos fármacos , Fator de Crescimento Transformador beta1/químicaRESUMO
Understanding the anatomy of the ankle ligaments is important for correct diagnosis and treatment. Ankle ligament injury is the most frequent cause of acute ankle pain. Chronic ankle pain often finds its cause in laxity of one of the ankle ligaments. In this pictorial essay, the ligaments around the ankle are grouped, depending on their anatomic orientation, and each of the ankle ligaments is discussed in detail.
Assuntos
Articulação do Tornozelo/anatomia & histologia , Ligamentos Articulares/anatomia & histologia , Ligamentos Colaterais/anatomia & histologia , Humanos , Ilustração MédicaRESUMO
Understanding the anatomy of the ankle ligaments is important for correct diagnosis and treatment. Ankle ligament injury is the most frequent cause of acute ankle pain. Chronic ankle pain often finds its cause in laxity of one of the ankle ligaments. In this pictorial essay, the ligaments around the ankle are grouped, depending on their anatomic orientation, and each of the ankle ligaments is discussed in detail.
Assuntos
Articulação do Tornozelo/anatomia & histologia , Tornozelo/anatomia & histologia , Ligamentos Articulares/anatomia & histologia , Articulação do Tornozelo/irrigação sanguínea , Fenômenos Biomecânicos , Epífises/anatomia & histologia , Humanos , Procedimentos Cirúrgicos Minimamente Invasivos , Procedimentos OrtopédicosRESUMO
To verify the eventual relationship between maxillary lateral incisor agenesis (MLIA) and one of the clinically established facial biotypes. The analysis was performed in and between 3 groups: individuals with MLIA, their relatives and a control population defined as "normal" or unaffected. Among these, a comparison between adults and growing individuals was also carried out. The dolicofacial biotype was mainly found in children with bilateral agenesis, while the unilateral agenesis as well as the control population of unaffected children showed mainly a mesofacial pattern. The braquiofacial biotype was prevalent in children without agenesis but (family) related to patients with agenesis. This is the case also for all the adults studied, even if the frequency of the braquiofacial is similar to the one attained by the mesofacial biotype when found in unaffected individuals related with agenesis patients. The notable variability found, evidenced by the high values of the standard deviations calculated for each group, makes difficult to definitely establish a positive correlation between the MLIA and one of the facial biotypes with the present data.
El objetivo fue verificar la eventual relación entre la agenesia de los incisivos lLaterales maxilares (AILM) y los biotipos faciales establecidos en clínica. Se realizó un análisis en tres grupos de sujetos: (i) pacientes afectos de AILM, (ii) sus familiares y (iii) una población control no afecta, definida como normal. Entre los grupos también se comparó a los sujetos en periodo de crecimiento con los adultos. El biotipo dolicofacial fue descrito principalmente en niños con agenesias bilaterales, mientras que los pacientes con agenesias unilaterales y la población control presentaban mayoritariamente un patrón mesofacial. El patrón braquifacial fue prevalente en niños no afectos de agenesia pero miembros de la familia de pacientes afectos de agenesia. Lo mismo se observó en todos los pacientes adultos, aunque la prevalencia del biotipo braquifacial resultó similar a la del biotipo mesofacial en pacientes no afectos de agenesia, pero con relación familiar a pacientes afectos. La notable variabilidad en el grupo sometido a estudio, evidente por los elevados valores de DE obtenidos en cada grupo, no permite establecer de manera definitiva una correlación positiva entre la AILM y un biotipo morfológicos facial, al menos con los datos hasta ahora disponibles.